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Butcher's broom extract put to the test for vein health

NCT ID NCT07737236

Disease control Sponsor: Turkish Society for Vascular and Endovascular Surgery Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This study follows over 500 people with chronic venous disease who are taking Ruscus aculeatus L., a plant extract also known as butcher's broom, as part of their routine care. Researchers will track changes in vein-related symptoms, pain, and quality of life over 90 days. The goal is to see how well the treatment works in real-world conditions and how consistently patients take it.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a plant extract called Ruscus aculeatus L. (butcher's broom)
What this could lead to
If the results are positive, this could support the use of Ruscus aculeatus as a standard treatment for chronic venous disease.
What could go wrong
This is an observational study, not a controlled trial, so it cannot prove cause and effect. The results may be influenced by other factors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 564 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults aged 18 to 75 years with symptomatic chronic venous disease (CEAP C1-C6) who are prescribed Ruscus aculeatus L. as part of routine clinical practice and provide written informed consent.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 75 years. * Patients prescribed Ruscus aculeatus L. as part of routine clinical practice, with the baseline visit performed within 7 days after treatment initiation. * Symptomatic chronic venous disease classified as CEAP (2020) C1-C6. * Willing and able to provide written informed consent and complete study as sessments. Exclusion Criteria: * Symptomatic patients classified as CEAP C0. * Uncontrolled hypertension. * Lower extremity dermatitis or ulcer related to peripheral arterial disease or diabetes. * Neurological or orthopedic conditions limiting mobility or independent walking. * Active systemic infection. * Known malignancy or ongoing chemotherapy. * Acute deep vein thrombosis or acute superficial vein thrombosis. * Cognitive or physical conditions preventing participation in routine follow-up visits. * Pregnant or breastfeeding women.

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Conditions

The condition(s) this trial relates to.

chronic venous insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic venous disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    25 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ankara Training and Research Hospital

    RECRUITING

    Ankara, Ankara, Turkey (Türkiye)

  • Ankara University Faculty of Medicine Hospital

    RECRUITING

    Ankara, Ankara, Turkey (Türkiye)

  • Antalya City Hospital

    RECRUITING

    Antalya, Turkey (Türkiye)

  • Bagcilar Training and Research Hospital

    RECRUITING

    Istanbul, Istanbul, Turkey (Türkiye)

  • Bahcelievler State Hospital

    RECRUITING

    Istanbul, Istanbul, Turkey (Türkiye)

  • Bakırköy Sadi Konuk Eğitim Araştırma Hastanesi

    NOT_YET_RECRUITING

    Istanbul, Istanbul, Turkey (Türkiye)

  • Bakırçay Üniversitesi Çiğli Eğitim ve Araştırma Hastanesi

    RECRUITING

    Izmir, İzmir, Turkey (Türkiye)

  • Bezmiâlem Foundation University Hospital

    RECRUITING

    Istanbul, Istanbul, Turkey (Türkiye)

  • Bilkent City Hospital

    RECRUITING

    Ankara, Ankara, Turkey (Türkiye)

  • Ege University Faculty of Medicine Hospital

    RECRUITING

    Izmir, İzmir, Turkey (Türkiye)

  • Etlik City Hospital

    RECRUITING

    Ankara, Ankara, Turkey (Türkiye)

  • Gazi University Faculty of Medicine Hospital

    NOT_YET_RECRUITING

    Ankara, Ankara, Turkey (Türkiye)

  • Gaziantep University Faculty of Medicine Hospital

    NOT_YET_RECRUITING

    Gaziantep, Gaziantep, Turkey (Türkiye)

  • Inonu University Turgut Ozal Medical Center

    RECRUITING

    Malatya, Malatya, Turkey (Türkiye)

  • Kahramanmaraş Sütçü İmam University Faculty of Medicine

    RECRUITING

    Kahramanmaraş, Kahramanmaraş, Turkey (Türkiye)

  • Kartal Dr. Lütfi Kırdar City Hospital

    RECRUITING

    Istanbul, Istanbul, Turkey (Türkiye)

  • Koşuyolu High Specialization Training and Research Hospital

    RECRUITING

    Istanbul, Istanbul, Turkey (Türkiye)

  • Mustafa Kemal University Hospital

    NOT_YET_RECRUITING

    Antakya, Hatay, Turkey (Türkiye)

  • Necmettin Erbakan University Meram Faculty of Medicine Hospital

    RECRUITING

    Konya, Konya, Turkey (Türkiye)

  • Prof. Dr. Cemil Taşcıoğlu City Hospital

    NOT_YET_RECRUITING

    Istanbul, Istanbul, Turkey (Türkiye)

  • SBU Gulhane Training and Research Hospital

    RECRUITING

    Ankara, Ankara, Turkey (Türkiye)

  • SBU Sincan Training and Research Hospital

    RECRUITING

    Ankara, Ankara, Turkey (Türkiye)

  • SBÜ Şişli Hamidiye Etfal Training and Research Hospital

    RECRUITING

    Istanbul, Istanbul, Turkey (Türkiye)

  • Sivas Cumhuriyet University Faculty of Medicine Research and Application Hospital

    RECRUITING

    Sivas, Sivas, Turkey (Türkiye)

  • Yıldırım Beyazıt University Yenimahalle Training and Research Hospital

    RECRUITING

    Ankara, Ankara, Turkey (Türkiye)

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Other studies related to the condition(s) this trial covers.