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Brain zaps may soothe Parkinson's pain, study finds
NCT ID NCT05537597
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) for musculoskeletal pain in people with Parkinson's disease. Researchers aimed to see if stimulating a specific brain area could reduce pain and improve quality of life. 62 participants completed the trial, and the study also looked at how the treatment affects brain activity using EEG.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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62 people
The number who actually took part.
- Started
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Oct 2022
- Finished
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Dec 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Idiopathic PD was diagnosed according to the 2015 Movement Disorder Society (MDS) clinical diagnostic criteria 2. Hoehn and Yahr stages of I to III 3. musculoskeletal pain was detected based on the Ford classification system for pain in PD. Pain duration of at least 3 months, with continuous moderate intensity pain (≥ 3/10 on a 0-10 numerical rating scale) occurring at least three days per week. 4. stable antiparkinsonian therapy for ≥4 weeks Exclusion Criteria: 1. Contraindications to rTMS 2. unstable ongoing psychiatric disorder, history of substance abuse (alcohol, drugs) 3. histories of deep brain stimulation surgery 4. Mini-mental State Examination scores ≤24 5. Other pain conditions, such as apparent osteoarthritis, or rheumatoid arthritis depended on laboratory or imaging findings
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Neurology, Second Affiliated Hospital of Soochow University
Suzhou, Jiangsu, 215004, China
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Other studies related to the condition(s) this trial covers.
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