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Zapping the brain to fix wobbly ankles: new study tests rTMS

NCT ID NCT06971705

Symptom relief Sponsor: Wuhan University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can improve chronic ankle instability when combined with standard ankle training. Forty adults with a history of ankle sprains will receive either real or sham rTMS before their exercises over 4 weeks. Researchers will measure ankle stability, muscle activity, and brain changes using questionnaires and fMRI scans.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
repetitive transcranial magnetic stimulation (rTMS)
What this could lead to
If it works, this could offer a new, non-invasive way to improve ankle stability and reduce re-injury risk by targeting brain activity.
What could go wrong
This is a small, early-phase study with only 40 people. The results may not apply to everyone, and the sham group might also improve from training alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Mar 2025

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18-60 years. 2. History of at least one significant ankle sprain within the past 12 months, accompanied by inflammatory response (including pain resulting in at least one day of restricted physical activity). 3. The most recent ankle sprain must have occurred more than 3 months prior to enrollment. 4. Self-reported symptoms of ankle instability, defined by one or more of the following: At least two episodes of "giving way" in the affected ankle within the past 6 months; Recurrent sprains (≥2 documented sprains in the same ankle); Subjective perception of instability confirmed by any one of the following validated instruments: Ankle Instability Instrument (AII): ≥5 affirmative responses; Cumberland Ankle Instability Tool (CAIT): Score \<24; Identification of Functional Ankle Instability (IdFAI): Score \>11. 5. Foot and Ankle Ability Measure (FAAM): Activities of Daily Living (ADL) subscale \<90%; FAAM Sports subscale \<80%; Foot and Ankle Outcome Score (FAOS): Scores \<75% in ≥3 subcategories. Exclusion Criteria: 1. Chronic ankle instability caused by bilateral ankle sprains; 2. History of lower extremity musculoskeletal or neurological surgery; 3. History of lower extremity fractures; 4. Acute musculoskeletal injuries in other lower extremity joints within 3 months that compromised joint integrity and function, resulting in ≥1 day of interrupted daily or sports activities; 5. Concomitant severe systemic diseases (cardiac, pulmonary, hepatic, renal, etc.); 6. Severe psychiatric disorders or cognitive impairments; 7. Presence of metal implants or inability to tolerate MRI examinations. 8. Patient refusal to participate.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic ankle instability, cai Functional magnetic resonance imaging (FMRI)

Contacts and locations

Locations

  • Zhongnan hospital of Wuhan University

    Wuhan, Hubei, 430070, China

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