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Brain zaps may ease breathlessness, early study hints

NCT ID NCT05623696

Knowledge-focused Sponsor: Oxford Brookes University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a painless magnetic brain stimulation technique called rTMS can reduce the feeling of breathlessness (air hunger) in 21 healthy adults. Participants breathed air with extra carbon dioxide to trigger moderate breathlessness while receiving real or fake rTMS over the front part of the brain. The goal is to understand how the brain controls breathlessness, which could eventually lead to new treatments for people with heart or lung disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
repetitive transcranial magnetic stimulation (rTMS)
What this could lead to
If it works, this could point toward new treatments for breathlessness in patients with heart or lung disease.
What could go wrong
This is a small, early study in healthy volunteers, not patients. The effect may not translate to real-world breathlessness or lead to a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

21 people

The number who actually took part.

Started

Feb 2022

Finished

May 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: healthy individuals, over 18 years old, with no history of heart, lung or neurological conditions Exclusion Criteria: * Any history of respiratory problems (including Asthma that involves regular use of inhalers) * Any history of heart or circulatory problems (e.g. palpitations, arrhythmias, angina, BP) * Any history of epilepsy, convulsions or seizures, migraines, or fainting * Any history of anxiety disorders (e.g. panic attacks) * Any history of serious head injury or brain surgery * Any metal parts in the head (except dental wire) * Any implants (e.g. pacemaker, insulin pump, neurostimulator) * Pregnancy or problems with alcohol or drug abuse.

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Conditions

The condition(s) this trial relates to.

Dyspnea

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dyspnea

Contacts and locations

Locations

  • Oxford Brookes University

    Oxford, Oxfordshire, OX3 0BP, United Kingdom

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