Brain zaps show promise for autism symptoms in small trial
NCT ID NCT06524310
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a noninvasive technique called repetitive transcranial magnetic stimulation (rTMS) could improve cognitive functions and behavior in 35 children with autism spectrum disorder (ASD), aged 5 to 11. The treatment uses magnetic pulses to gently stimulate brain areas linked to social thinking and behavior. Researchers measured changes in thinking skills, autism severity, and blood biomarkers before and after the sessions.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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35 people
The number who actually took part.
- Started
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Jul 2024
- Finished
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Sep 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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5 to 11 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Target population: * Autistic individuals * previously Diagnosed with ASD using the American Psychiatric Association's DSM-V criteria * previously Diagnosed using the Autism Diagnostic Observation Schedule (ADOS). Inclusion Criteria: * Male and female ASD individuals * age between 5 and 11 years old * diagnosed with ASD on prior clinical assessment using the American Psychiatric Association's DSM-V criteria and corroborated by assessment using the Autism Diagnostic Observation Schedule (ADOS). * Normal hearing ability based on past hearing screens. * Participation will be limited to higher functioning (intelligence quotient \[IQ\] \>70) to maximize successful completion of tested paradigms, maintain alertness/attention, furthermore, the ability to follow instructions. Exclusion Criteria: * Individuals that are known to have epilepsy ( including Hx. of febrile convulsion) or have a family history of epilepsy. * Any individual with a previous Hx. Of head injuries * Any individual has been diagnosed with psychiatric illness, including ADHD, depression, psychosis, bipolar disorder, anxiety disorders, or OCD. * Individuals using a combination of Psychotropic Medications known for their significant seizure threshold lowering potential, for example, and not as a limitation: Bupropion, Citalopram, Duloxetine, Fluoxetine, Fluvoxamine, Mirtazapine, Paroxetine, Sertraline, Venlafaxine, Tricyclics, Olanzapine, Quetiapine, Aripiprazole, Ziprasidone, and Risperidone. * The presence of metallic objects, e.g., cranium clips or implanted biomedical devices.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Physiology, Autism Research and Treatment Center (ARTC), King Saud University Medical City (KSUMC)/Collage of Medicine, King Saud University
Riyadh, Riyadh Region, 12372, Saudi Arabia
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Other studies related to the condition(s) this trial covers.
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