Rosacea mystery: gut and skin bacteria under the microscope

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants must be over the age of 18 years old. * Participants must have a current diagnosis of moderate-to-severe erythematotelangiectatic or papulopustular rosacea or free of rosacea to serve as control. * Participants must have the ability to understand and communicate with the investigator. * Participants must be willing and comply with the requirements of the protocol. * Participants must provide written informed consent Exclusion Criteria: * Subjects unable to provide informed consent. * Subjects with significant medical history or concurrent illness that the investigator feels are not safe for study participation. * Recently treated (4 weeks for topical antibiotics/steroids/other anti- inflammatory medications on the face, 8 weeks for systemic antibiotics/steroids/other immunosuppressive agents) or current (skin) diseases that would affect clinical evaluation and skin sampling. * Subjects with a history of facial surgeries and cosmetic procedures (i.e. laser therapy, resurfacing, dermal fillers, and deep chemical peels) within 6 months. * Subjects with facial features (i.e. significant hair growth) that would affect clinical evaluation and skin sampling. * Participants with a history of chronic gastrointestinal disease, diabetes mellitus, cardiac disease or immunodeficiency disease. * Intake of proton pump inhibitors, H2 receptor antagonists, laxatives, or antidiarrheal medication, NSAIDs, or antacids within 2 weeks prior to enrollment. * Participants with a history of major surgery of the GI tract (5 years). * Participants with a known hypersensitivity to tetracyclines or doxycycline or topical ivermectin * Subjects unwilling to avoid facial washing for 24 hours prior to sampling and to come to sampling visit without make-up. * Subjects with known allergy to lidocaine and epinephrine. * Subjects with known bleeding disorders. * Subjects with a history of keloids or excessive scarring. * Pregnant subjects. Self-reporting will be used to determine whether a patient is pregnant