Could a bone drug help women with anorexia? new study investigates

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female * Age 20-60 years, skeletally mature with closed epiphyses * Body mass index (BMI) ≥ 16.5 kg/m2 * Anorexia nervosa or atypical anorexia nervosa defined by DSM-V diagnostic criteria * BMD Z-score \< -1.0 * Normal serum 25-OH vitamin D (\>30 ng/mL) and calcium levels * For women of reproductive age, agree to use an effective contraceptive method. Highly effective methods of birth control include: Combined (estrogen and progestogen) hormonal methods (pills, vaginal ring, or skin patch); Intrauterine device (IUD); Intrauterine hormonal-releasing system (IUS); Surgery to tie both fallopian tubes (bilateral tubal ligation/occlusion); Woman's male partner has had a vasectomy and testing shows there is no sperm in the semen * Dental check-up within the past year Exclusion Criteria: * Hospitalization within 3 months of baseline study visit, including inpatient eating disorder treatment facility; participating in a residential eating disorder treatment program within 3 months of study participation is permitted * Myocardial infarction or stroke within 1 year preceding enrollment * History of hypertension or use of anti-hypertensive medications within the past 6 months * Any disease known to affect bone, including untreated thyroid dysfunction, Cushing's or renal failure * Any medication known to affect bone metabolism within 3 months of the study, excluding oral contraceptives or other forms of estrogen administration. Bisphosphonates must have been discontinued for at least one year before participation * Immunodeficiency or taking immunosuppressive therapy * Serum 25-OH vitamin D level \<30 ng/mL * Serum potassium \<3.0 meq/L * Serum magnesium \<1.5 meq/L * Serum ALT \>3 times upper limit of normal * eGFR of less than 30 ml/min * LDL \> 190 mg/dL * Hypocalcemia * Diabetes mellitus * Active substance abuse, including alcohol * Current smoker * History of malignancy * Paget disease of bone * Osteomalacia * Osteonecrosis of the jaw (ONJ) or risk factor for ONJ, such as invasive dental procedures (eg, tooth extraction, dental implants, oral surgery in the past 6 months), poor oral hygiene, periodontal and/or pre-existing dental disease, and current use of corticosteroids. * Planned invasive dental procedure over the next 24 months * Known sensitivity to any of the products or components of the medication to be administered * Sensitivity to calcium or vitamin D supplements * Pregnant, planning to become pregnant within 12 months after the end of treatment and/or breastfeeding * Hypersensitivity to any component of zoledronic acid