New hope for Tough-to-Treat blood cancers: rocbrutinib takes on pirtobrutinib in Head-to-Head trial
NCT ID NCT07342478
First seen Jan 16, 2026 · Last updated May 22, 2026 · Updated 14 times
Summary
This study tests a new oral drug, rocbrutinib, against another drug, pirtobrutinib, in adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) whose cancer has returned or not responded after prior treatment with a BTK inhibitor. About 306 participants will be randomly assigned to take one of the two pills daily. The main goal is to see which drug better delays cancer growth or death. This is not a cure, but aims to control the disease for as long as possible.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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OSU Comprehensive Cancer Center
NOT_YET_RECRUITINGColumbus, Ohio, 43210, United States
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Optum Medical Group (Rhodes) P.C.
RECRUITINGLas Vegas, Nevada, 89102, United States
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The Center for Cancer and Blood Disorders-Bethesda
RECRUITINGBethesda, Maryland, 20817, United States
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UPMC Hillman Cancer Center
NOT_YET_RECRUITINGPittsburgh, Pennsylvania, 15213, United States
Conditions
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