Robotic legs may retrain walking in Parkinson's — a trial puts the tech to the test
NCT ID NCT06225830
First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time
Summary
This study tests whether a robotic exoskeleton called Ekso can help people with Parkinson's disease improve their walking, balance, and quality of life. Over eight weeks, participants will use the device in two weekly sessions, with the robot gradually reducing assistance as they improve. The trial aims to see if high-repetition, high-intensity gait training is feasible and beneficial for this condition.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a robotic exoskeleton (Eksobionics Eksoskeleton NR) that assists leg movements during gait training
- What this could lead to
- If effective, this approach could offer a new way to improve mobility and quality of life for people with Parkinson's disease.
- What could go wrong
- This is a small, early-stage study with only 24 participants, so results may not apply to everyone. The device requires upper body strength and may not suit all stages of Parkinson's.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 24 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2024
- Expected to finish
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Sep 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Physician diagnosed idiopathic Parkinson's disease 2. All Hoehn and Yahr (H\&Y) stages will be eligible for inclusion in the study 3. Able to consent to participation in the research study 4. Pt agreeable to participate in 45-60 minutes of high intensity (RPE 14-17 for 30 minutes) gait training/ physical therapy. 5. Sufficient upper extremity strength to use a front wheeled walker 6. Pt to have self- reported walking/balance deficits 7. Age: Over age 18 8. Must be able to tolerate at least 15 min upright 9. Weigh 220 pounds (100kg) or less 10. Approximately between 5'0" and 6'4" tall 11. Have near normal range of motion in hips, knees, and ankles "Can you stand up and straighten your knees even for just a second?" or "Can you lay flat and straighten your knees so there is no bend in the knee?" Exclusion Criteria: 1. Currently involved in another intervention study or physical therapy course of care 2. Concurrent neurological disease 3. Leg length discrepancy, self-reported. 4. Spinal instability 5. Unresolved deep vein thrombosis 6. Severe muscular or skeletal pain 7. Open skin ulcerations on buttocks or other body surfaces in contact with exoskeleton or harness 8. Pregnancy 9. Cognitive impairments - unable to follow 2 steps commands and communicate for pain or to stop session 10. Participant requires the assistance of more than one therapist to transfer safely. 11. Uncontrolled or severe orthostatic hypotension that limits standing tolerance; defined as sustained, symptomatic drops in systolic and diastolic blood pressure when moving from sitting to standing 12. Active heterotrophic ossification (HO), hip dysplasia or hip/knee axis abnormalities 13. Colostomy 14. History of long bone fractures secondary to osteoporosis 15. Unable to sustain current medication regimen. Participant reports change in Parkinson's Medication in the past week. 16. Any reason the therapist may deem as harmful to the participant to enroll or continue in the study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Jefferson Moss-Magee Rehabilitation - Elkins Park
Elkins Park, Pennsylvania, 19027, United States
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