Immune drug rituximab tested to shrink prostate tumors before surgery

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ability to understand and provide written informed consent. * Patient has EITHER: * A Kattan nomogram predicted probability of being disease free 5 years after surgery of \< 60%, OR * A Gleason sum ≥ 8. * Indicated for radical prostatectomy. Note: candidates for radical prostatectomy are still eligible even if they have a history of deep venous thrombosis, pulmonary embolism, and/or cerebrovascular accident or currently requiring systemic anticoagulation. * Eastern Cooperative Oncology Group (ECOG) performance status of 0-1 (Appendix A). * Males aged ≥ 18 years. * Adequate organ function as defined below measured within 21 days of study entry: * Hematology: * Absolute Neutrophil Count (ANC) ≥ 1.5 x 109/L * Platelet count ≥ 100 x 109/L * Hemoglobin ≥ 9.0 g/dL * White blood cell (WBC) count ≥ 3.0 x 109/L * Biochemistry: * Aspartate aminotransferase/serum glutamic-oxaloacetic transaminase (AST/SGOT) and alanine transaminase/serum glutamate pyruvate transaminase (ALT/SGPT) ≤ 2 x institution's upper limit of normal (ULN) * Total bilirubin \<1.5 times ULN * Serum creatinine and blood urea nitrogen (BUN)\<1.5 times ULN * Na, K Cl, carbon dioxide (CO2), Ca, phosphate (PO4) within institutional limits * Available prostate biopsy specimen which is evaluable for B lymphocyte count. Exclusion Criteria: * Received prior treatment for prostatic adenocarcinoma including prior surgery (excluding TURP), radiation therapy, or chemotherapy. * Current or past use of investigational agents within 4 weeks of study enrollment. * Evidence of metastatic disease on cross sectional imaging or bone scan. * History of hepatitis B or C, hepatitis immunodeficiency virus (HIV), tuberculosis or a chronic infection of any type. * Positive test results for chronic hepatitis B infection (defined as positive HBsAg serology). * Positive test results for hepatitis C (hepatitis C virus \[HCV\] antibody serology testing).