Gut feeling: new supplement aims to soothe digestion and boost mood
NCT ID NCT06834984
First seen Jun 27, 2026 · Last updated Sep 11, 2026 · Updated 2 times
Summary
This study is testing whether a daily dietary supplement called Synbiotic+, which contains probiotics, prebiotics, and postbiotics, can improve gastrointestinal symptoms like bloating and irregular bowel movements in healthy women aged 25-65. Researchers will also look at markers of gut inflammation, immune health, and mood. The 60 participants will take either the supplement or a placebo for several weeks, and their gut health will be tracked through stool samples, diaries, and questionnaires.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a dietary supplement containing probiotics (Lactobacillus rhamnosus LGG and Bifidobacterium animalis subsp. lactis BB-12), a prebiotic (bacteriophages), and a postbiotic (tributyrin)
- What this could lead to
- If it works, this could point toward a simple daily supplement to reduce bloating, gas, and other common gut issues while also supporting mood and immune health.
- What could go wrong
- This is a small, early-stage study with only 60 healthy women, so results may not apply to everyone. The supplement is not a treatment for any disease, and benefits may be modest or no better than placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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103 people
The number who actually took part.
- Started
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May 2025
- Finished
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Sep 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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25 to 65 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Healthy adult women (age 25-65, with target average age of 50). * BMI \<30. * with moderate gastrointestinal symptoms. * Participants should be willing to follow the study protocol and attend clinic visits. Exclusion Criteria: * less than 25 years of age or greater than 65 years of age. * have a BMI \>30. * taken antibiotics within two months or any probiotic supplements within the past 14 days prior to the start of treatment. * current medications and dietary supplements will be assessed on a case-by- case basis and will result in exclusion if there is the possibility that the drugs or supplements used would influence the endpoints of the study. This would include statins, metformin, NSAIDs, MAO inhibitors, and hormone therapies. * Individuals with current disease diagnosis, including diagnosis of cancer, liver or kidney disease, gastrointestinal diseases, and cardiometabolic disorders (cardiovascular disease, diabetes, etc.) * pregnant and breastfeeding people. * overuse of alcohol as determined on a case-by-case self-reported alcohol use. * if the individual feels they are unable to adhere to the study requirements, which includes consuming capsules, providing stool or blood samples, tracking bowel movements and symptoms, and attending scheduled clinic visits.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Colorado State University Food and Nutrition Clinical Research Laboratory
Fort Collins, Colorado, 80523, United States