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Hope for SMA babies: new drug may restore movement after gene therapy falters

NCT ID NCT05861999

First seen Nov 01, 2025 · Last updated May 20, 2026 · Updated 29 times

Summary

This study tests a medicine called risdiplam in babies under 2 years old with spinal muscular atrophy (SMA) who stopped getting better or started losing skills after receiving gene therapy. The goal is to see if risdiplam can help them regain motor abilities like sitting and moving. About 28 children will take part, and researchers will track their progress over 72 weeks using a standard motor skills test.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Charité - Universitätsmedizin Berlin SPZ Abteilung Neuropaediatrie

    RECRUITING

    Berlin, 13353, Germany

  • Children'S Hospital of Philadelphia

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Children's Healthcare of Atlanta Center for Advanced Pediatrics

    RECRUITING

    Atlanta, Georgia, 30329-2309, United States

  • Children's Hospital of Colorado

    RECRUITING

    Aurora, Colorado, 80045, United States

  • Children's Hospital of the King's Daughter

    RECRUITING

    Norfolk, Virginia, 23510, United States

  • Great Ormond Street Hospital For Children

    RECRUITING

    London, WC1N 3JH, United Kingdom

  • Helen DeVos Children's Hospital at Spectrum Health

    RECRUITING

    Grand Rapids, Michigan, 49503, United States

  • Instytut Pomnik Centrum Zdrowia Dziecka

    RECRUITING

    Warsaw, 04-730, Poland

  • Schneider Children's Medical Center of Israel

    RECRUITING

    Petah Tikva, 4920235, Israel

  • Sidra Medicine

    RECRUITING

    Al Rayyan, Qatar

  • Soroka Medical Center

    RECRUITING

    Beersheba, 8410101, Israel

  • Sourasky MC, Dana-Dwek Children's Hospital

    RECRUITING

    Tel Aviv, 6423906, Israel

  • Stanford Univ Medical Center

    RECRUITING

    Palo Alto, California, 94304, United States

  • UKGM Standort Gießen

    RECRUITING

    Giessen, 35392, Germany

  • University of Arkansas for Medical Sciences

    RECRUITING

    Little Rock, Arkansas, 72103, United States

  • University of Florida Pediatrics

    RECRUITING

    Gainesville, Florida, 32610, United States

  • University of Texas Southwestern Medical Center

    RECRUITING

    Dallas, Texas, 75390, United States

  • Uniwersyteckie Centrum Kliniczne

    RECRUITING

    Gdansk, 80-952, Poland

  • Valley Children's Hospital

    RECRUITING

    Madera, California, 93636, United States

Conditions

Explore the condition pages connected to this study.