Study aims to uncover hidden heart strain during ICU fluid therapy

NCT ID NCT07537621

Knowledge-focused Sponsor: CHU de Reims Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This observational study looks at how the right side of the heart adapts when critically ill patients receive fluids. Researchers will use ultrasound to measure heart function before and after fluid administration in 100 adults. The goal is to understand why some patients develop fluid-related congestion, even when their heart seems to respond well to fluids.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors better understand how to give fluids to critically ill patients without harming the heart, potentially leading to safer fluid management in ICUs.
What could go wrong: This is an observational study, not a treatment trial. It will not directly test a new therapy, and results may not change practice immediately. The findings are based on a small group of 100 patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Jun 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adult critically ill patients with acute circulatory failure. Eligible patients are those for whom the attending physician independently decides to perform fluid loading as part of standard care, in accordance with current European recommendations. Patients may present with hypotension requiring vasopressor support, low mean arterial pressure, or other signs of hemodynamic instability. Participants are prospectively and consecutively included at the time of fluid loading decision, and undergo standardized echocardiographic assessment of right ventricular function and venous congestion before and after fluid administration. The population reflects routine clinical practice in the intensive care unit.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Critically ill hospitalized patients * Age ≥ 18 years * Patients undergoing fluid loading at the discretion of the attending physician, following prediction of fluid responsiveness using any recommended maneuver or dynamic parameter, in the setting of acute circulatory failure requiring vasopressor support and/or mean arterial pressure \< 65 mmHg (or a decrease of ≥ 30 mmHg from baseline in patients with chronic hypertension), and/or other signs of hemodynamic instability (tachycardia, mottling, oliguria, hyperlactatemia) * Affiliated with a national health insurance system Exclusion criteria : * Formal refusal from the patient or legally representative after information * Patients transferred from another intensive care unit * Pregnant or postpartum patients * Acute respiratory distress (defined as respiratory rate ≥ 35 breaths/min and/or signs of increased work of breathing) * Ongoing acute coronary syndrome * Acute or pulmonale (defined by right ventricular dilation associated with paradoxical septal motion related to an abrupt increase in right ventricular afterload) * Primary pulmonary arterial hypertension * Intra-abdominal hypertension (intravesical pressure \> 15 mmHg) * Poor echogenicity precluding adequate echocardiographic assessment of the right ventricle * Severe valvular heart disease or early postoperative period following valvular surgery

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Conditions

The condition(s) this trial relates to.

cardiogenic shock Hyperemia Shock Ventricular Dysfunction, Right

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Right ventricular dysfunction Shock Venous congestion

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Study aims to uncover hidden heart strain during ICU fluid therapy

What the study statuses mean