One-Shot gene therapy could end frequent eye injections for wet AMD

NCT ID NCT04704921

Ongoing Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Mar 06, 2026 · Last updated May 01, 2026 · Updated 12 times

Summary

This study tests a one-time gene therapy called RGX-314 for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The goal is to see if a single treatment can control the disease and reduce the need for repeated eye injections. About 671 adults aged 50 to 89 who have already responded to standard therapy are participating.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Advanced Research, LLC /ID# 275451

Deerfield Beach, Florida, 33064-1342, United States
Associated Retinal Consultants /ID# 256156

Royal Oak, Michigan, 48073, United States
Atrium Health Wake Forest Baptist Medical Center /ID# 270767

Winston-Salem, North Carolina, 27157, United States
Austin Clinical Research, LLC /ID# 256043

Austin, Texas, 78750-2298, United States
Austin Research Center for Retina /ID# 256148

Austin, Texas, 78705, United States
Austin Retina Associates - Austin /ID# 256053

Austin, Texas, 78705, United States
Barnet Dulaney Perkins Eye Center - Sun City /ID# 256055

Sun City, Arizona, 85351, United States
Bascom Palmer Eye Institute - University of Miami /ID# 256072

Miami, Florida, 33136, United States
Baylor Scott & White Surgicare /ID# 256122

Fort Worth, Texas, 76104, United States
Black Hills Regional Eye Institute /ID# 256161

Rapid City, South Dakota, 57701, United States
California Eye Specialists Medical Group Inc. /ID# 256079

Pasadena, California, 91107, United States
California Retina Consultants - Santa Barbara /ID# 256017

Santa Barbara, California, 93103, United States
Charles Retina Institute /ID# 256016

Germantown, Tennessee, 38138, United States
Charleston Neuroscience Institute /ID# 256235

Ladson, South Carolina, 29456, United States
Cincinnati Eye Institute- Edgewood /ID# 256132

Edgewood, Kentucky, 41017-3415, United States
Cleveland Clinic Main Campus /ID# 256064

Cleveland, Ohio, 44195, United States
Colorado Retina Associates /ID# 256121

Lakewood, Colorado, 80228, United States
Cumberland Valley Retina Consultants - Hagerstown /ID# 256151

Hagerstown, Maryland, 21740, United States
Duke Eye Center /ID# 256076

Durham, North Carolina, 27705, United States
Erie Retina Research /ID# 256154

Erie, Pennsylvania, 16507, United States
Eye Associates of New Mexico /ID# 256075

Albuquerque, New Mexico, 87109, United States
Florida Retina Consultants /ID# 265661

Lakeland, Florida, 33805, United States
Georgia Retina - Marietta /ID# 256142

Marietta, Georgia, 30060, United States
John A. Moran Eye Center /ID# 256068

Salt Lake City, Utah, 84132, United States
John-Kenyon American Eye Institute -New Albany /ID# 256065

New Albany, Indiana, 47150-3620, United States
Johns Hopkins Hospital /ID# 256015

Baltimore, Maryland, 21287, United States
Long Island Vitreoretinal Consultants /ID# 256074

Great Neck, New York, 11021, United States
Marietta Eye Clinic /ID# 268163

Marietta, Georgia, 30060, United States
Mayo Clinic - Minnesota /ID# 256051

Rochester, Minnesota, 55905, United States
Mid Atlantic Retina /ID# 256013

Philadelphia, Pennsylvania, 19107, United States
Northern California Retina Vitreous Associates Medical Group, Inc /ID# 256298

Mountain View, California, 94040-4101, United States
Ochsner Medical Center - Jefferson Highway /ID# 270524

New Orleans, Louisiana, 70121, United States
Ophthalmic Consultants of Boston /ID# 256014

Boston, Massachusetts, 02114, United States
Orange County Retina Medical Group /ID# 256073

Santa Ana, California, 92705, United States
Pacific Northwest Retina /ID# 256155

Bellevue, Washington, 98004, United States
Retina Associates - Lenexa /ID# 256080

Lenexa, Kansas, 66215, United States
Retina Associates of Cleveland-Middleburg Heights /ID# 256052

Cleveland, Ohio, 44130, United States
Retina Associates of Michigan /ID# 266198

Grand Blanc, Michigan, 48439, United States
Retina Associates of New Orleans /ID# 272440

Metairie, Louisiana, 70006-2940, United States
Retina Associates of Utah /ID# 256044

Salt Lake City, Utah, 84107, United States
Retina Center NW, PLLC /ID# 256157

Silverdale, Washington, 98383, United States
Retina Center Of Texas (Rct) - Southlake /ID# 256056

Southlake, Texas, 76092, United States
Retina Consultants - The Woodlands /ID# 256018

The Woodlands, Texas, 77384, United States
Retina Consultants Of Texas /ID# 268611

San Antonio, Texas, 78240, United States
Retina Consultants of Hawaii /ID# 256049

‘Aiea, Hawaii, 96701, United States
Retina Consultants of Orange County /ID# 256152

Fullerton, California, 92835, United States
Retina Consultants of San Diego /ID# 256021

Poway, California, 92064-2530, United States
Retina Consultants of Southern Colorado /ID# 256069

Colorado Springs, Colorado, 80909, United States
Retina Consultants of Texas - Beaumont /ID# 266279

Beaumont, Texas, 77707, United States
Retina Group of New England - Waterford /ID# 256071

Waterford, Connecticut, 06385-1215, United States
Retina Northwest, PC /ID# 256140

Portland, Oregon, 97221, United States
Retina Partners Midwest, PC /ID# 256045

Indianapolis, Indiana, 46290, United States
Retina Research Institute of Texas /ID# 256141

Abilene, Texas, 79606-1224, United States
Retina Specialty Institute /ID# 256153

Pensacola, Florida, 32503, United States
Retina Vitreous Assoc Med Grp /ID# 256299

Beverly Hills, California, 90211, United States
Retina Vitreous Associates of Florida - St. Petersburg /ID# 256050

St. Petersburg, Florida, 33711-1141, United States
Retina Vitreous Center, Research /ID# 256067

Edmond, Oklahoma, 73013, United States
Retina Vitreous Consultants - Monroeville /ID# 271654

Monroeville, Pennsylvania, 15146, United States
Retina and Vitreous of Texas /ID# 263961

Bellaire, Texas, 77401, United States
Retina-Vitreous Surgeons of Central New York - Liverpool /ID# 266274

Liverpool, New York, 13088, United States
Retinal Consultants Medical Group /ID# 256047

Sacramento, California, 95825, United States
Retinal Diagnostic Center /ID# 256137

Campbell, California, 95008, United States
Retinal Research Institute /ID# 256019

Phoenix, Arizona, 85053, United States
Salehi Retina Institute /ID# 263485

Huntington Beach, California, 92647, United States
Sierra Eye Associates /ID# 256020

Reno, Nevada, 89502, United States
Southeast Retina Center /ID# 256022

Augusta, Georgia, 30909, United States
Southern Vitreoretinal Associates /ID# 256158

Tallahassee, Florida, 32308, United States
Southwest Retina Research Center /ID# 256136

Durango, Colorado, 81303, United States
Springfield Clinic /ID# 266225

Springfield, Illinois, 62702-3749, United States
Stone Oak Surgery Center /ID# 266199

San Antonio, Texas, 78240, United States
Texas Retina Associates - Dallas /ID# 256133

Dallas, Texas, 75231, United States
The Retina Care Center /ID# 256144

Baltimore, Maryland, 21209, United States
The Retina Group Of Washington - Chevy Chase /ID# 276039

Chevy Chase, Maryland, 20815, United States
The Retina Institute /ID# 266587

St Louis, Missouri, 46214, United States
The Retina Partners - Encino /ID# 256054

Encino, California, 91436, United States
Thomas Eye Group PC /ID# 268159

Sandy Springs, Georgia, 30328-4411, United States
UC Irvine/Gavin Herbert Eye Institute /ID# 256145

Irvine, California, 92697, United States
UCLA Doheny Eye Center /ID# 256120

Pasadena, California, 91105, United States
University Retina and Macula Associates /ID# 256077

Oak Forest, Illinois, 60452, United States
University Retina and Macula Associates /ID# 256078

Lemont, Illinois, 60439, United States
University of Arkansas for Medical Sciences /ID# 271290

Little Rock, Arkansas, 72205, United States
University of California, San Francisco /ID# 256130

San Francisco, California, 94143, United States
University of Illinois at Chicago /ID# 256300

Chicago, Illinois, 60607, United States
University of Wisconsin-Madison, Department of Ophthalmology and Visual Sciences /ID# 256159

Madison, Wisconsin, 53705-3644, United States
Verum Research, LLC /ID# 266585

Eugene, Oregon, 97401, United States
VitreoRetinal Surgery PLLC DBA Retina Consultants of Minnesota /ID# 256160

Edina, Minnesota, 55435, United States
Vitreoretinal Associates, P.A. /ID# 256150

Gainesville, Florida, 32607, United States
Wagner Macula & Retina Center - Norfolk /ID# 256134

Norfolk, Virginia, 23502, United States
West Coast Retina /ID# 256448

San Francisco, California, 94107, United States

Conditions

Explore the condition pages connected to this study.

AMD CHOROIDAL NEOVASCULARIZATION CHOROIDAL NEOVASCULARIZATION CNV NAMD NEOVASCULAR AGE-RELATED MACULAR DEGENERATION NEOVASCULAR AMD WAMD WET AGE-RELATED MACULAR DEGENERATION WET AMD