Cooling down, warming up: speed matters after cardiac arrest?
NCT ID NCT02555254
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 58 adults who had a cardiac arrest and were cooled to 33°C to protect their brains. Researchers compared two rewarming speeds (slow at 0.25°C per hour vs. fast at 0.50°C per hour) to see how it affected inflammation levels in the blood. The goal was to gather information, not to test a treatment.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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58 people
The number who actually took part.
- Started
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Feb 2016
- Finished
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Jun 2020
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient has been supported for a shockable cardiac arrest with successful resuscitation. * Coma persistent at ICU admission (Glasgow score less than or equal to 8) in the absence of sedation. If the patient is sedated in ICU admission, the glasgow score will be held the last evaluated by the doctor who provided the pre-hospital care of the patient score. * Body temperature\> 33 ° C * Specific device used to targeted temperature management at 33°C Exclusion Criteria: * Lack of witness of cardiac arrest. * Duration of no-flow\> 10 minutes (time between the onset of cardiac arrest and the start of external cardiac massage). * Duration of low-flow\> 60 minutes (the period between the start of external cardiac massage and recovery of an effective cardiac activity). * Major hemodynamic instability (dose norepinephrine and / or epinephrine \> 1 µg / kg / min to maintain MAP\> 65 mmHg). * Time between cardiac arrest and more than 480 minutes inclusion * Moribund. * Presence of histologically confirmed cirrhosis of Child class C. * Patient treatment in blocking the production of Il6 (Ro-tocilizumab or Actemra ®) * Patient under corticosteroid treatment (dose\> 5 mg of prednisolone equivalent) * Pregnant woman, parturient or lactating. * Inpatient without consent and / or deprived of liberty by a court decision. * Patient under guardianship * Inclusion in advance a research protocol with the draw, and whose primary endpoint is on interleukin-6. * Lack of social security. * Refusal of the trusted person or patient.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Colin Gwenhael
La Roche-sur-Yon, 85000, France
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