Anesthesia mystery: why do some patients relax again after reversal?
NCT ID NCT04048655
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looks at a puzzling event where some patients' muscles relax again after being reversed from anesthesia. Researchers will monitor 120 adults having elective surgery to see how often this happens. The goal is to understand the phenomenon better, not to test a new treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Neostigmine
- What this could lead to
- If successful, this study could help anesthesiologists better understand and prevent unexpected muscle relaxation after surgery.
- What could go wrong
- This is an observational study, not a treatment trial. It only measures how often a phenomenon occurs, so it won't directly lead to a new therapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Apr 2020
- Expected to finish
-
Dec 2025
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Elective surgery requiring general anaesthesia * Surgery is assumed to last more than 45 minutes * Body mass index less than 35kg/ m² Exclusion Criteria: * Disease of central nervous system * Trauma of central nervous system * Disease affecting peripheral nervous system * Medication affecting peripheral nervous system
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Tampere University Hospital
Tampere, 33520, Finland
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a new drug improve muscle relaxation during surgery?