Can surgery buy more time for ovarian cancer patients?
NCT ID NCT07295132
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether a second surgery to remove visible tumors (secondary cytoreductive surgery) after chemotherapy helps women with platinum-sensitive recurrent ovarian cancer. About 160 participants will be randomly assigned to get surgery plus chemo or chemo alone. The goal is to see if surgery delays the cancer from growing back.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Secondary cytoreductive surgery (surgery to remove visible tumor) and platinum-based chemotherapy
- What this could lead to
- If successful, this could show that adding surgery after chemotherapy helps women with recurrent ovarian cancer live longer without their cancer getting worse.
- What could go wrong
- This is a Phase 2 trial with only 160 participants, so results are preliminary. Surgery carries risks like infection or complications, and it may not improve survival for all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 160 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Dec 2025
An estimate. Start dates often move.
- Expected to finish
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Nov 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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19 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * First recurrence of platinum-sensitive, invasive epithelial ovarian, fallopian tube, or primary peritoneal cancer, regardless of initial stage. * A progression-free interval of at least 6 months after the end of the last platinum-containing regimen. * Demonstrated response during neoadjuvant chemotherapy after recurrence (Complete Response/Partial Response/Stable Disease according to RECIST 1.1 or GCIG CA-125 response, which is a ≥50% reduction in pre-treatment CA-125 level sustained for ≥28 days). * Women aged 19 years or older. * The tumor is judged to be completely resectable by surgery (R0) based on the judgment of an experienced surgeon * Patients who provide signed and written informed consent and consent to data transfer and processing. Exclusion Criteria: * Patients without recurrence * Patients with non-epithelial tumors or borderline tumors. * Patients with second, third, or subsequent recurrence. * Patients with a secondary malignancy treated with laparotomy and other neoplasms, where the treatment is expected to interfere with the treatment of recurrent ovarian cancer or significantly affect prognosis. * Patients with platinum-refractory tumors (i.e., progression during chemotherapy or recurrence within 6 months after the end of the previous first platinum-containing regimen). * Cases where only palliative surgery is planned. * Radiological signs suggestive of metastasis that are considered completely unresectable. * Any comorbidity that precludes surgery and/or chemotherapy (e.g., poor general condition, severe infection, conditions that may cause severe bleeding, severe renal disease, etc.). * Any medical history that may cause excessive surgical risk pre- or post-operatively. * Medications being taken that pose a significant surgical risk (e.g., oral anticoagulants, bleeding risk due to bevacizumab). * Absence of evaluable archived tumor tissue.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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