Brain blood flow under the knife: remimazolam vs propofol
NCT ID NCT07303985
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how remimazolam, a newer sedative, changes blood flow in the brain compared to the standard drug propofol during the start of anesthesia. Fifty-two adults having planned surgery took part. The goal was to measure blood flow speed in a key brain artery right after the drugs were given and after the breathing tube was placed. The results could help anesthesiologists choose the best sedative for patients where brain blood flow is a concern.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Remimazolam
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
-
52 people
The number who actually took part.
- Started
-
Dec 2025
- Finished
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Mar 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients who have signed the informed consent form and are willing to comply with the study protoco * Age greater than 18 years * ASA physical status classification I to II * Scheduled for elective surgery * Undergoing general anesthesia with endotracheal intubation * No history of cerebrovascular disease, carotid artery stenosis, or traumatic brain injury. Exclusion Criteria: * History of intracranial lesions, carotid artery stenosis, or traumatic brain injury * Allergy or contraindications to remimazolam or propofol.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Fudan University Shanghai Cancer Centre
Shanghai, China
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