Can less radiation be just as effective for nasopharyngeal cancer?
NCT ID NCT06239727
First seen Mar 10, 2026 · Last updated Jun 23, 2026 · Updated 13 times
Summary
This Phase 3 trial is testing whether a lower dose of radiation, combined with chemotherapy and immunotherapy, can control stage III nasopharyngeal cancer as well as the standard higher dose. About 593 participants whose tumors respond well to initial treatment will be randomly assigned to receive either reduced or standard radiation. The goal is to maintain cancer control while reducing long-term side effects from radiation.
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This is a summary of
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Locations
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Affiliated Hospital of Guangdong Medical University
RECRUITINGZhanjiang, Guangdong, China
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Cancer Hospital of Guangxi Medical University
RECRUITINGNanning, Guangxi, China
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Cancer Hospital of Guizhou Medical University
RECRUITINGGuiyang, Guizhou, China
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Cancer Hospital of Shantou University Medical College
RECRUITINGShantou, Guangdong, China
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Chongqing Cancer Hospital
RECRUITINGChongqing, China
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Dongguan People's Hospital
RECRUITINGDongguan, Guangdong, China
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Fujian Cancer Hospital
RECRUITINGFuzhou, Fujian, China
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Guangdong Nongken Central Hospital
RECRUITINGZhanjiang, Guangdong, China
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Hubei Province Cancer Hosiptal
RECRUITINGWuhan, Hubei, China
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Hunan Cancer Hospital
RECRUITINGChangsha, Hunan, 410000, China
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Jiangsu Cancer Hospital
RECRUITINGNanjing, Jiangsu, China
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Jiangsu Provinee Hospital of Chinese Medicine
RECRUITINGNanjing, Jiangsu, China
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Jiangxi Cancer Center
RECRUITINGNanchang, Jiangxi, China
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Sichuan Cancer Hospital
RECRUITINGChengdu, Sichuan, China
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Sun Yat-Sen University Cancer Center
RECRUITINGGuangzhou, Guangdong, 510060, China
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The Affiliated Panyu Central Hospital of Guangzhou Medical University
RECRUITINGGuangzhou, Guangdong, 511400, China
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The First Affiliated Hospital of Xiamen University
RECRUITINGXiamen, Fujian, China
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The First Affiliated Hospital of Xian Jiaotong University
RECRUITINGXian, Shanxi, China
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The First People's Hospital of Foshan
RECRUITINGFoshan, Guangdong, 528000, China
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The Second Affiliated Hospital of Hainan Medical University
RECRUITINGHaikou, Hainan, China
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Tianjin Medical University Cancer Institute & Hospital
RECRUITINGTianjin, China
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Tongji Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology
RECRUITINGWuhan, Hubei, China
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Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology
RECRUITINGWuhan, Hubei, China
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West China Hospital，Sichuan University
RECRUITINGChengdu, Sichuan, China
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Xiangya Hospital Central South University
RECRUITINGChangsha, Hunan, China
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Zhejiang Cancer Hospital
RECRUITINGHangzhou, Zhejiang, China
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Camrelizumab (PD-1 blocking antibody), gemcitabine, cisplatin, and reduced-dose radiotherapy
What this could lead to
If successful, this could offer a treatment option that uses lower radiation doses, potentially reducing long-term side effects while still controlling the cancer.
What could go wrong
This is a Phase 3 trial, but it is still experimental. Lower radiation might not control the cancer as well as standard doses, and the combination with immunotherapy could cause unexpected side effects.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.