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Scientists probe red blood cells to unlock clues to sickle cell and anemia

NCT ID NCT03541525

Knowledge-focused Sponsor: Imagine Institute Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 09, 2026 · Last updated Sep 10, 2026 · Updated 1 time

Summary

Researchers are studying blood, urine, and tissue samples from people with red blood cell disorders and their relatives to learn more about how these diseases work. The goal is to find new ways to measure spleen function, iron processing, and inflammation. Participants provide samples that scientists analyze in the lab. This research may help doctors better understand and eventually treat conditions like sickle cell disease and Diamond-Blackfan anemia.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could improve how doctors measure spleen function, iron metabolism, and inflammation in red blood cell disorders, which may guide better care.
What could go wrong
This is an observational study that collects samples rather than testing a treatment, so it may not lead to new therapies. Findings from lab tests may not translate into clinical benefits for patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 3,750 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2017

Expected to finish

Oct 2037

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Inclusion of patients affected by red blood cell disorder and their non affected relatives

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * To be affected or have a family history of disease bound to the red blood cell, * For adult subjects, have signed an informed consent form, * For minor or major under legal safeguard subjects, the form must be signed by both parents (for minors) or by the legal representative, * Be affiliated to health insurance. Exclusion Criteria: * Being deprived of freedom

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Conditions

The condition(s) this trial relates to.

erythrocyte disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Red blood cell disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    25 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CHU Amiens-Picardie

    RECRUITING

    Amiens, France

  • CHU Hôpital de la Mère et de l'enfant Lagune

    NOT_YET_RECRUITING

    Cotonou, Benin

  • CHU Kremlin Bicetre

    RECRUITING

    Le Kremlin-Bicêtre, France

  • CHU de Niort

    RECRUITING

    Niort, France

  • CHU de Rouen

    RECRUITING

    Rouen, France

  • CHU de la Guadeloupe

    NOT_YET_RECRUITING

    Pointe-à-Pitre, Guadeloupe

  • Groupe Hospitalier Diaconesses Croix Saint Simon

    RECRUITING

    Paris, France

  • Hopital Henri Mondor

    RECRUITING

    Créteil, France

  • Hopital Necker - Enfants malades

    RECRUITING

    Paris, France

  • Hopital de la conception

    RECRUITING

    Marseille, France

  • Hôpital Armand Trousseau

    RECRUITING

    Paris, France

  • Hôpital Avicenne

    RECRUITING

    Bobigny, France

  • Hôpital Beaujon

    RECRUITING

    Clichy, France

  • Hôpital Cochin

    RECRUITING

    Paris, France

  • Hôpital Européen Georges-Pompidou

    RECRUITING

    Paris, France

  • Hôpital Louis Mourier

    RECRUITING

    Colombes, France

  • Hôpital Pellegrin

    RECRUITING

    Bordeaux, France

  • Hôpital Privé d'Antony

    RECRUITING

    Antony, France

  • Hôpital Robert Debré

    NOT_YET_RECRUITING

    Paris, France

  • Hôpital Saint Eloi

    RECRUITING

    Montpellier, France

  • Hôpital Saint Louis

    RECRUITING

    Paris, France

  • Hôpital Saint-Antoine

    RECRUITING

    Paris, France

  • Hôpital d'Enfants de la TIMONE

    RECRUITING

    Marseille, France

  • Hôpital national d'instruction des armées Bégin

    RECRUITING

    Saint-Mandé, France

  • Institut Pasteur

    RECRUITING

    Paris, France

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