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Cure My Disease

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Massive study tracks 15,000 people to unravel long COVID mysteries

NCT ID NCT05172024

Knowledge-focused Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This large observational study followed over 15,000 adults in the U.S. to learn more about long COVID (Post-Acute Sequelae of SARS-CoV-2 infection). Researchers tracked symptoms, health history, and biological samples over time in both infected and uninfected people. The goal is to identify risk factors and patterns of long COVID, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could identify who is at risk for long COVID and what symptoms to expect, guiding future treatments.
What could go wrong
This is an observational study, not a treatment trial. It cannot prove what causes long COVID or offer a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

15,172 people

The number who actually took part.

Started

Oct 2021

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Infected: Individuals at least 18 years of age meet WHO criteria for suspected, probable or confirmed SARS-CoV-2 infection on or after March 1, 2020. Uninfected: Individuals at least 18 years of age who have never met any of the WHO criteria for suspected, probable or confirmed SARS-CoV-2 infection.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: INFECTED COHORT -- ADULTS WITH SUSPECTED SARS-COV-2 INFECTION -- An adult qualifies as having suspected SARS-CoV-2 infection if meeting criteria a, b or c below: 1. Patients who meet the following clinical criteria plus one of the epidemiological criteria: Clinical Criteria: Acute onset of fever and cough OR acute onset of any three of more of the following signs or symptoms: fever, cough, general weakness /fatigue, headache, myalgia, sore throat, coryza, dyspnea, anorexia/nausea/vomiting, diarrhea, altered mental status. Epidemiological Criteria: 1. Residing or working in an area with a high risk of transmission of virus: closed residential settings, humanitarian settings such as camp and camp-like settings for displaced persons; anytime within the 14 days before symptom onset; or 2. Residing or travel to an area with community transmission anytime within the 14 days before symptom onset; or 3. Working in any health care setting, including within health facilities or within the community; anytime within the 14 days before symptom onset. 2. A patient with severe acute respiratory illness: (acute respiratory infection with history of fever or measured fever of ≥38C°; and cough; with onset within the last 10 days; and requires hospitalization). 3. An asymptomatic person not meeting epidemiologic criteria with a positive SARS-CoV-2 Antigen-RDT. ADULTS WITH PROBABLE SARS-COV-2 INFECTION -- An adult qualifies as having probable SARS-CoV-2 infection if meeting any one of a-d below: 1. A patient who meets clinical criteria for suspected SARS-CoV-2 AND is a contact of a probable or confirmed case or linked to a COVID-19 cluster; 2. A suspect case with chest imaging showing findings suggestive of COVID-19 disease; 3. A person with recent onset of anosmia (loss of smell) or ageusia (loss of taste) in the absence of any other identified cause; 4. Death, not otherwise explained, in an adult with respiratory distress preceding death AND was a contact of a probable or confirmed case or linked to a COVID-19 cluster ADULTS WITH CONFIRMED SARS-COV-2 INFECTION -- An adult qualifies as having confirmed SARS-CoV-2 infection if meeting any one of a-d below: 1. Any person with a positive Nucleic Acid Amplification Test (NAAT); 2. Any person with a positive SARS-CoV-2 Antigen-RDT OR positive SARS-CoV-2 antibody test\* AND meeting either the probable case definition or suspect criteria A OR B; 3. An asymptomatic person with a positive SARS-CoV-2 Antigen-RDT who is a contact of a probable or confirmed case 4. Any person with a positive SARS-CoV-2 nucleocapsid protein antibody test OR a positive SARS-CoV-2 spike protein antibody test IF not vaccinated * (\*)This protocol modifies the WHO criterion b to add detectable SARS-CoV-2 antibody as a qualifying test. UNINFECTED COHORT -- ADULTS WITH NO SARS-COV-2 INFECTION -- * Does not meet WHO criteria for a suspected, probable, or confirmed case of SARS-CoV-2 infection, AND * Has a documented negative SARS-CoV-2 PCR test from a respiratory specimen in the past, if being enrolled as a post-acute control (see XII.H), AND * Has a documented negative SARS-CoV-2 PCR test from a respiratory specimen at the time of enrollment/screening, AND * Has a negative SARS-CoV-2 nucleocapsid protein antibody and spike protein antibody test (spike only if not vaccinated) at the time of enrollment, AND * Live in the same communities or recruited from the same sources as those in the SARS-CoV-2 infected cohort, AND * Note: uninfected individuals may participate independent of their vaccination status Exclusion Criteria: * Individuals who have not yet reached the age of majority * Unable to provide consent * Individuals in hospice care * Any serious medical condition which would prevent long-term participation * Individuals participating in the study NIH RECOVER-Pediatric: Understanding the long-term impact of COVID on children and families * Incarcerated individuals

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Conditions

The condition(s) this trial relates to.

COVID-19 long COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SARS-COV2 infection

Contacts and locations

Locations

  • Banner University Medical Center (BUMC) - Phoenix

    Phoenix, Arizona, 85006, United States

  • Bateman Horne Center

    Salt Lake City, Utah, 84102, United States

  • Beth Israel Deaconess Medical Center (BIDMC)

    Boston, Massachusetts, 02215, United States

  • Boston University

    Boston, Massachusetts, 02215, United States

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Cambridge Health Alliance (CHA)

    Cambridge, Massachusetts, 02139, United States

  • Case Western Reserve University

    Cleveland, Ohio, 44106, United States

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

  • ChristianaCare Health System

    Newark, Delaware, 19718, United States

  • Columbia University

    New York, New York, 10032, United States

  • Columbia University (Pregnancy)

    New York, New York, 10032, United States

  • Denver Health and Hospital Authority

    Denver, Colorado, 80204, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Emory University

    Atlanta, Georgia, 30322, United States

  • George Washington University

    Washington D.C., District of Columbia, 20052, United States

  • Good Samaritan Hospital

    Cincinnati, Ohio, 45220, United States

  • Harvard Medical School

    Boston, Massachusetts, 02115, United States

  • Harvard School Of Public Health

    Boston, Massachusetts, 02115, United States

  • Hispanic Alliance for Clinical and Translational Research

    San Juan, 00927, Puerto Rico

  • Howard University

    Washington D.C., District of Columbia, 20059, United States

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Institute for Systems Biology (ISB)

    Seattle, Washington, 98109, United States

  • Intermountain Medical Center (Intermountain Healthcare)

    Salt Lake City, Utah, 84107, United States

  • Kaiser Permanente Georgia

    Atlanta, Georgia, 30305, United States

  • LDS Hospital - Intermountain Healthcare

    Salt Lake City, Utah, 84143, United States

  • Louisiana State University (LSU)

    New Orleans, Louisiana, 70112, United States

  • Louisiana State University - Pennington Biomedical Research Center

    Baton Rouge, Louisiana, 70808, United States

  • MaineHealth

    Portland, Maine, 04101, United States

  • Mass General Brigham - Harvard University

    Boston, Massachusetts, 02114, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • McKay-Dee Hospital

    Ogden, Utah, 84403, United States

  • Medical College Of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Memorial Hermann Health System

    Houston, Texas, 77024, United States

  • Metrohealth System

    Cleveland, Ohio, 44109, United States

  • Miami Valley Hospital

    Dayton, Ohio, 45409, United States

  • Morehouse School of Medicine (MSM)

    Atlanta, Georgia, 30310, United States

  • NewYork-Presbyterian Hospital

    Queens, New York, 11355, United States

  • Northshore University HealthSystem

    Glenview, Illinois, 60026, United States

  • Northwestern University

    Evanston, Illinois, 60208, United States

  • Ochsner Health System

    New Orleans, Louisiana, 70115, United States

  • Prisma Health Upstate

    Greenville, South Carolina, 29605, United States

  • Providence Regional Medical Center Everett

    Everett, Washington, 98201, United States

  • Providence Sacred Heart Medical Center

    Spokane, Washington, 99204, United States

  • Saint Peter's University Hospital

    New Brunswick, New Jersey, 08901, United States

  • Sanford Health

    Sioux Falls, South Dakota, 57106, United States

  • St. David's Health Care

    Austin, Texas, 78758, United States

  • Stanford University

    Stanford, California, 94305, United States

  • Swedish Medical Center

    Seattle, Washington, 98109, United States

  • The MetroHealth System (Pregnancy Cohort)

    Cleveland, Ohio, 44109, United States

  • The Ohio State University - Wexner Medical Center

    Columbus, Ohio, 43210, United States

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • Tulane University

    New Orleans, Louisiana, 70118, United States

  • UTMB Health League City Campus Hospital & Clinics

    League City, Texas, 77573, United States

  • University Hospitals MacDonald's Women's Hospital

    Cleveland, Ohio, 44106, United States

  • University Medical Center New Orleans

    New Orleans, Louisiana, 70112, United States

  • University Of Nebraska Medical Center

    Omaha, Nebraska, 68198, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35294, United States

  • University of Alabama at Birmingham (Pregnancy Cohort)

    Birmingham, Alabama, 35294, United States

  • University of Arizona

    Tucson, Arizona, 85724, United States

  • University of California San Francisco (Pregnancy Cohort)

    San Francisco, California, 94115, United States

  • University of California, San Francisco (UCSF)

    San Francisco, California, 94143, United States

  • University of Colorado Denver

    Denver, Colorado, 80204, United States

  • University of Hawai'i - Mānoa's John A. Burns School of Medicine

    Honolulu, Hawaii, 96822, United States

  • University of Illinois at Chicago

    Chicago, Illinois, 60608, United States

  • University of Kansas Medical Center (KUMC)

    Kansas City, Kansas, 66160, United States

  • University of Kentucky

    Lexington, Kentucky, 40506, United States

  • University of Mississippi Medical Center (UMMC)

    Jackson, Mississippi, 39216, United States

  • University of New Mexico Health Sciences Center

    Albuquerque, New Mexico, 87102, United States

  • University of North Carolina (UNC) at Chapel Hill

    Chapel Hill, North Carolina, 27516, United States

  • University of North Dakota

    Grand Forks, North Dakota, 58202, United States

  • University of Oklahoma Health Sciences Center (OUHSC)

    Oklahoma City, Oklahoma, 73104, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Pittsburgh Medical Center (UPMC)

    Pittsburgh, Pennsylvania, 15213, United States

  • University of South Alabama

    Mobile, Alabama, 36688, United States

  • University of Texas Health Science Center at Houston

    Houston, Texas, 77024, United States

  • University of Texas Health Science Center at San Antonio

    San Antonio, Texas, 78229, United States

  • University of Texas Medical Branch (UTMB) Galveston

    Galveston, Texas, 77555, United States

  • University of Utah

    Salt Lake City, Utah, 84112, United States

  • University of Utah Health

    Salt Lake City, Utah, 84132, United States

  • University of Washington

    Seattle, Washington, 98104, United States

  • Utah Valley Regional Medical Center

    Provo, Utah, 84604, United States

  • WakeMed Health & Hospitals

    Raleigh, North Carolina, 27610, United States

  • West Virginia University

    Morgantown, West Virginia, 26506, United States

  • Women & Infants Hospital

    Providence, Rhode Island, 02905, United States

  • Yale School of Medicine (YSM)

    New Haven, Connecticut, 06510, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.