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New study examines Real-World side effects of lung cancer therapies

NCT ID NCT07215962

First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 30 times

Summary

This study tracks 300 patients with advanced non-small cell lung cancer whose tumors have low PD-L1 levels (below 1%). Researchers will look at side effects and healthcare use for different first-line treatments, including combinations of immunotherapy drugs like nivolumab and ipilimumab with or without chemotherapy. The goal is to understand how these treatments work in everyday practice, outside of controlled clinical trials.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Florida Cancer Specialists & Research Institute

    Fleming Island, Florida, 32003, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Nivolumab, ipilimumab, and other immunotherapy drugs combined with chemotherapy

What this could lead to

If successful, this could help doctors choose safer and more effective first-line treatments for advanced lung cancer patients with low PD-L1 levels.

What could go wrong

This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may not apply to all patients or settings.

Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.