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New pill aims to shorten Kids' colds – trial underway

NCT ID NCT06715891

Symptom relief Sponsor: Materia Medica Holding Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests whether Raphamin tablets can reduce cold symptoms in 374 children aged 3 to 12. Children with fever and other cold signs will receive either Raphamin or a placebo. The main goal is to see how quickly symptoms like fever and congestion go away.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Raphamin (also called MMH-407) tablet
What this could lead to
If it works, this could provide a new option to help children recover faster from common cold symptoms.
What could go wrong
This is an early-phase trial with a placebo group, so the real benefit is still unproven. The effect may be small or no better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 374 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

3 to 12 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Children of either gender aged 3 to12 years . 2. Diagnosis of ARVI based on the medical examination: axillary temperature ≥37.8°C at the time of examination + total severity of general symptom score ≥4 points, nasal/throat/chest symptoms ≥2 points (ARVI Symptom Severity Score). 3. 24 hours from the ARVI onset . 4. Availability of a patient information sheet and an informed consent form for the patient's parents/adopters for patient participation in the clinical trial signed by one parent/adopter of the patient. Exclusion Criteria: 1. Clinical symptoms of severe influenza/ARVI requiring hospitalization. 2. Suspected pneumonia, bacterial infection (including otitis media, sinusitis, urinary tract infection, meningitis, sepsis, etc.) requiring the administration of antibiotics from the first day of disease. 3. Suspected early manifestations of diseases that have onset symptoms similar to those of ARVI (other infectious diseases, influenza-like syndrome at the onset of systemic connective tissue diseases and other pathologies). 4. Patients who require administration of antiviral medications that are prohibited for use in this trial. 5. History or prior diagnosis of primary and secondary immunodeficiency. 6. History/suspicion of oncology of any localization (except for benign neoplasms). 7. Exacerbation or decompensation of chronic diseases (diabetes mellitus, cerebral palsy, cystic fibrosis, primary ciliary dyskinesia, bronchopulmonary dysplasia, malformations of the respiratory and ENT organs, etc.) affecting the patient's ability to participate in the clinical trial. 8. Malabsorption syndrome, including congenital or acquired lactase or other disaccharidase deficiency, galactosemia. 9. Allergy/hypersensitivity to any component of the medicines used in the treatment. 10. Use of medications listed under "Prohibited Concomitant Treatment" within 2 weeks prior to inclusion in the trial. 11. Patients whose parents/adopters, from the investigator's point of view, will not comply with the observation requirements during the trial or follow the procedure for taking the test drugs. 12. History of mental illness of the patient (except for attention deficit hyperactivity disorder), parents/adopters of the patient. 13. Participation in other clinical trials within 3 months prior to inclusion in this trial. 14. A patient's parent/adopter is related to any of the on-site research personnel directly involved in the trial, or is the immediate family member of the investigator. 'Immediate family members' mean spouses, parents, children, or siblings, whether related or adopted. 15. The patient's parent/adopter is employed by OOO "NPF "MATERIA MEDICA HOLDING", i.e., is an employee of the company, a temporary contract employee, or a designated official responsible for conducting the trial or their immediate family member.

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Conditions

The condition(s) this trial relates to.

viral respiratory tract infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory viral infection

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    34 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Bashkir State Medical University/Department of Outpatient and Emergency Pediatrics

    RECRUITING

    Ufa, 450008, Russia

  • Central Research Institute of Epidemiology/Clinical Department of Infectious Pathology

    RECRUITING

    Moscow, 111123, Russia

  • Children's City Clinical Hospital # 11 Ekaterinburg

    RECRUITING

    Yekaterinburg, 620028, Russia

  • Children's City Polyclinic # 35

    RECRUITING

    Saint Petersburg, 196191, Russia

  • Children's City Polyclinic # 44

    RECRUITING

    Saint Petersburg, 191144, Russia

  • City Children's Clinical Polyclinic # 5

    RECRUITING

    Perm, 614066, Russia

  • City Polyclinic # 3

    NOT_YET_RECRUITING

    Saint Petersburg, 199155, Russia

  • City Polyclinic # 4

    NOT_YET_RECRUITING

    Saint Petersburg, 199178, Russia

  • Clinical Hospital # 2

    RECRUITING

    Yaroslavl, 150030, Russia

  • Clinical and diagnostic center "Health"

    RECRUITING

    Rostov-on-Don, 344011, Russia

  • First Moscow State Medical University named after I.M. Sechenov/Department of Childhood Diseases

    RECRUITING

    Moscow, 119991, Russia

  • Gatchina Clinical Interdistrict Hospital

    RECRUITING

    Gatchina, 188300, Russia

  • Kazan State Medical University/Department of Hospital Pediatrics

    RECRUITING

    Kazan', 420012, Russia

  • LLC "4D Ultrasound Clinic"

    RECRUITING

    Pyatigorsk, 357502, Russia

  • LLC "Eurodon Clinic"

    NOT_YET_RECRUITING

    Rostov-on-Don, 344022, Russia

  • LLC "Health Laboratory"

    NOT_YET_RECRUITING

    Mytishchi, 141002, Russia

  • LLC "MedLight"

    RECRUITING

    Kazan', 420097, Russia

  • LLC "Professor's Clinic"

    RECRUITING

    Perm, 614070, Russia

  • Llc "Diagnostics and Vaccines"

    TERMINATED

    Moscow, 129515, Russia

  • Morozovskaya Children's City Clinical Hospital of the Moscow City Health Department

    RECRUITING

    Moscow, 119049, Russia

  • National Research Mordovian State University named after N.P. Ogarev/Department of Pediatrics/

    RECRUITING

    Saransk, 430005, Russia

  • Novosibirsk State Medical University/Clinic "Medical Advisory Center"

    RECRUITING

    Novosibirsk, 630091, Russia

  • Omsk State Medical University/Department of Hospital Pediatrics with a Course of Continuing Professional Education

    RECRUITING

    Omsk, 644099, Russia

  • Regional Clinical Hospital # 2

    RECRUITING

    Krasnodar, 350012, Russia

  • Rostov State Medical University/Department of Childhood Diseases # 2

    NOT_YET_RECRUITING

    Rostov-on-Don, 344022, Russia

  • Rostov State Medical University/Department of Childhood Diseases # 3

    NOT_YET_RECRUITING

    Rostov-on-Don, 344022, Russia

  • Ryazan State Medical University named after Academician I.P. Pavlov/Department of Children's Diseases with a course in hospital pediatrics

    RECRUITING

    Ryazan, 390026, Russia

  • Saint Petersburg State Pediatric Medical University/Department of Infectious Diseases of Adults and Epidemiology

    RECRUITING

    Saint Petersburg, 194100, Russia

  • Samara Regional Children's Clinical Hospital named after N.N. Ivanovoy/Department of Medical Rehabilitation

    RECRUITING

    Samara, 443079, Russia

  • Samara State Medical University/Department of Hospital Pediatrics

    RECRUITING

    Samara, 443099, Russia

  • Saratov City Children's Clinical Hospital

    RECRUITING

    Saratov, 410064, Russia

  • Smolensk State Medical University/Department of Children's Diseases of the Medical and Dental Faculties

    RECRUITING

    Smolensk, 214019, Russia

  • Specialized Clinical Infectious Diseases Hospital

    RECRUITING

    Krasnodar, 350015, Russia

  • Ural State Medical University/Department of Infectious Diseases, Phthisiology and Pulmonology

    RECRUITING

    Yekaterinburg, 620028, Russia

  • Yaroslavl State Medical University/Department of Pediatrics, Institute of Continuous Professional Education

    RECRUITING

    Yaroslavl, 150000, Russia

More trials for these conditions

Other studies related to the condition(s) this trial covers.