AI image analysis may replace invasive biopsies for dental bone healing
NCT ID NCT07814092
First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time
Summary
Researchers are testing whether radiomics, a method that extracts hidden details from dental scans, can measure the quality of new bone after alveolar ridge preservation. The procedure fills a tooth socket with a xenograft material and a collagen membrane to keep bone ready for a future implant. Sixty adults scheduled for tooth extraction and later implant placement take part. Six months after the procedure, researchers compare radiomic features from CBCT scans with histomorphometry results from bone samples taken during implant placement. The goal is to build a model that lets dentists assess bone healing without invasive sampling.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- alveolar ridge preservation, a dental procedure that fills the tooth socket with a xenograft biomaterial and a collagen membrane
- What this could lead to
- If radiomics can reliably read bone quality from scans, dentists could assess healing after ridge preservation without cutting out a tissue sample. That may make follow-up simpler and help plan implants.
- What could go wrong
- The study is small, with 60 participants, and compares image features against biopsy results at a single time point. Radiomics models often fail to hold up in larger, more varied groups, and the approach may not match histomorphometry closely enough to replace it.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Oct 2025
- Expected to finish
-
Aug 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 75 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age between 18 and 75 y.o. * ASA \< 3 * Single-rooted teeth with indication to extraction * Sufficient bone height to permit standard-length implant placement (≥ 8.5 mm) * Presence of healthy oral mucosa with at least 3 mm of keratinized tissue * Presence of all socket walls * Buccal bone thickness \< 1 mm * Periodontal health or stability * Informed consent signed Exclusion Criteria: * General contraindication to oral surgery * Inflammatory or autoimmune diseases * Medical history of neoplastic pathology treated with radio- and/or chemotherapy in the last five years in the head and neck district * Medical history of antiresorptive, antiangiogenetic or high dosage corticosteroideal therapy * Uncontrolled diabetes (HbA1c \> 7%) * Allergy to porcine collagen * Pregnancy * Missing of compliance * One or more missing post-extractive socket walls * Extraction of adjacent teeth in the 6 months following ARP
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Alveolar bone preservation are added.
Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
SC Clinica di Chirurgia Maxillofacciale e Odontostomatologia
Trieste, Trieste, 34100, Italy
More trials for these conditions
Other studies related to the condition(s) this trial covers.