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Could this trial spare cancer patients unnecessary radiation?

NCT ID NCT01599559

Summary

This study aims to determine if radiation therapy is truly needed for patients with primary mediastinal B-cell lymphoma who have already responded well to chemotherapy. After completing chemotherapy, patients with negative PET scans (showing no active cancer) will be randomly assigned to either receive standard radiation treatment or careful observation without radiation. The goal is to see if avoiding radiation in these patients leads to similar cancer control while potentially reducing treatment side effects.

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Contacts and locations

Locations

  • A.O. Bianchi-Melacrino-Morelli, Divisione di Ematologia

    Reggio Calabria, Italy

  • A.O. SS. Antonio e Biagio e Cesare Arrigo

    Alessandria, Italy

  • A.O.U Policlinico Consorziale di Bari

    Bari, Italy

  • AO Garibaldi Nesima Catalia

    Catania, Italy

  • AO San Camillo Forlanini

    Roma, Italy

  • AOS Maria di Terni

    Terni, Italy

  • AOS S. Giovanni Battista "Molinette"

    Torino, Italy

  • AOU Policlinico di Modena

    Modena, Italy

  • AOU S. Andrea Roma

    Roma, Italy

  • AOU di Parma

    Parma, Italy

  • Asl Uoc Ematologia A Perrino

    Brindisi, Italy

  • Asst Settelaghi Ospedale Macchi

    Varese, Italy

  • Azienda Ospedaliera Citta Della Salute E Della Scienza Di Torino

    Torino, Italy

  • Azienda Ospedaliera Universitaria

    Padova, Italy

  • Azienda Ospedaliera Univesritaria

    Udine, Italy

  • Bari IRCCS Istituto Tumori

    Bari, Italy

  • Basingstoke & North Hamptshire Hospital

    Basingstoke, United Kingdom

  • Birmingham Heartlands Hospital

    Birmingham, United Kingdom

  • Centro de Hematologia y Oncologia Pavlovsky

    Buenos Aires, Argentina

  • Centro di Riferimento Oncologico - Aviano

    Aviano, Italy

  • Clinica di Ematologia Ospedali Riuniti "Umberto I"

    Ancona, Italy

  • Comprensorio Sanitario di Bolzano

    Bolzano, Italy

  • Ematologia Università degli Studi di Federico II

    Naples, Italy

  • Faculty Hospital Brno

    Brno, Czechia

  • Faculty Hospital Kralovske Vinohrady

    Prague, Czechia

  • Fondazione IRCCS S. Matteo

    Pavia, Italy

  • Fondazione PTV Policlinico Tor Vergata

    Roma, 00133, Italy

  • General Hospital

    Southampton, United Kingdom

  • General University Hospital

    Prague, Czechia

  • Glasgow Beatson Cancer Center

    Glasgow, United Kingdom

  • Guy's & St. Thomas London

    London, United Kingdom

  • ICCRS Azienda Ospedaliera Arcipedale "Santa Maria Nuova"

    Reggio Emilia, Italy

  • IOSI

    Bellinzona, 6500, Switzerland

  • Inselspital Bern

    Bern, Switzerland

  • Istituto Portugues de Oncologia de Lisboa

    Lisbon, Portugal

  • Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

    Meldola, Italy

  • Istituto Scientifico San Raffaele

    Milan, Italy

  • Kantonsspital

    Sankt Gallen, Switzerland

  • Kantonsspital Olten

    Olten, Switzerland

  • Kyiv National Cancer Institute

    Kiev, Ukraine

  • Leeds St. James's Hospital

    Leeds, United Kingdom

  • Lund Universitet

    Lund, Sweden

  • MD Anderson Cancer Center

    Houston, Texas, United States

  • Manchester The Christie NHS Foundation Trust

    Manchester, United Kingdom

  • Mayo Clinil Rocheser

    Rochester, Minnesota, 55905, United States

  • Milano Ieo

    Milan, Italy

  • Newcastle Freeman Hospital

    Newcastle, United Kingdom

  • Norfolk & Norwich University Hospital

    Norfolk, United Kingdom

  • Norton Cancer Institute

    Louisville, Kentucky, United States

  • Nottingham University Hospital

    Nottingham, United Kingdom

  • Oslo University Hospital

    Oslo, Norway

  • Ospedale Businco

    Cagliari, Italy

  • Ospedale Cardinale Panico

    Tricase, Italy

  • Ospedale Civico Guglielmo di Saliceto

    Piacenza, Italy

  • Ospedale Civile di Pescara

    Pescara, Italy

  • Ospedale Degli Infermi

    Rimini, Italy

  • Ospedale Mons. Dimiccoli

    Barletta, Italy

  • Ospedale Papa Giovanni Xxiii

    Bergamo, Italy

  • Ospedale S. Croce e Carle

    Cuneo, Italy

  • Ospedale S. Eugenio

    Roma, Italy

  • Ospedale San Carlo di Potenza

    Potenza, Italy

  • Ospedale Umberto I

    Nocera Inferiore, Italy

  • Ospedali Riuniti Villa Sofia

    Palermo, Italy

  • Policlinico Universitario Campus Bio-Medico

    Roma, Italy

  • Princess Margaret Hospital

    Toronto, Canada

  • Roma Regina Elena IFO

    Roma, Italy

  • Roma San Giovanni

    Roma, Italy

  • Royal Liverpool University Hospital

    Liverpool, United Kingdom

  • Rozzano Humanitas

    Rozzano, Italy

  • Ruijin Hospital

    Shanghai, China

  • S.C. Ematologia Ospedale S. Marid Della Misericordia

    Perugia, Italy

  • SC Ematologia AO Niguarda

    Milan, Italy

  • SC Ematologia Azienda Ospedali Riuniti Papardo Piemonte

    Messina, Italy

  • Sant'Orsola Malpighi

    Bologna, Italy

  • Siena

    Siena, Italy

  • Spedali Civili

    Brescia, Italy

  • St Olavs Hospital

    Trondheim, Norway

  • U.O. Ematologia Vito Fazzi

    Lecce, Italy

  • U.O. Oncologia Ematologia Ospedale S. Maria Delle Croci

    Ravenna, Italy

  • UCLH St. Thomas

    London, United Kingdom

  • Unità Funzionale di Ematologia AOU Careggi

    Florence, Italy

  • University Hospital

    Hradec Králové, Czechia

  • University of Duisburg-Essen, Campus Essen

    Essen, Germany

  • Università degli Studi La Sapienza

    Roma, Italy

  • Warsaw Centrum Onkologi Instytucie

    Warsaw, Poland

Conditions

Explore the condition pages connected to this study.