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Could a tiny skin shot replace the big rabies needle?
NCT ID NCT07345208
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two ways of giving the rabies vaccine: the standard shot in the muscle versus a smaller dose injected under the skin. Researchers want to see if the skin method works just as well and is as safe, while using less vaccine and costing less. About 90 healthy volunteers in Bangladesh will take part, and their immune response and side effects will be tracked for six months.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2/3
Runs two stages together: whether the treatment works, then large-scale confirmation.
- Participants
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About 90 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Dec 2025
An estimate. Start dates often move.
- Expected to finish
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Jul 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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5 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Healthy volunteers aged \>4 years * Able to comply with the research process and provide informed consent * Able to attend all the scheduled visits and comply with the trial procedures * Medical history and clinical examination demonstrating that the subject is healthy * Women willing to follow any method of contraception throughout the duration of the study. Exclusion Criteria: * Subjects participating in other clinical trials in the 4 weeks preceding the first trial vaccination dose * Subjects with a history of previous rabies vaccination (either pre- or post-exposure prophylaxis) * Subjects with a history of receiving Rabies immunoglobulin (Ig (human/equine) prior to the study * Subjects with a fever (≥37.2°C) or any moderate or severe acute illnesses or active infections on the day of vaccination * History of systemic hypersensitivity to any component included in the vaccine or a history of adverse events as a reaction to previous experimental vaccine studies * History of receiving any immunoglobulin, blood, or blood-based product in the last 3 months or planning to donate blood in the following 3 months, which may interfere with the immune response * Screened as positive for HBsAg, Anti-HCV, and anti-HIV * Subjects receiving any vaccine at least 4 weeks prior to enrolment or expected to receive any vaccine 4 weeks after the administration of the trial vaccine. * Lactating women or pregnant women as detected by the urine hCG strip test. * History of alcohol or any substance abuse (benzodiazepines, methamphetamines, opioids, cannabinoids, cocaine, barbiturates) within 1 year * Subjects with congenital or acquired immunodeficiency or subjected to short- or long-term corticosteroid or immunosuppressive therapy * Thrombocytopenia, bleeding disorders, or anticoagulants used during the 3 weeks prior to trial vaccination to avoid intramuscular haemorrhage * Any major psychiatric disorder such as schizophrenia, major depressive disorder, severe anxiety disorder, etc. * History of cardiac arrhythmias, such as bradycardia, tachycardia, supraventricular tachycardia (SVT), ventricular tachycardia (VT), ventricular fibrillation (VF), atrial fibrillation (AF), etc., as assessed by the electrocardiogram report * History of renal insufficiency or dialysis * Any immunosuppressive disorder, such as cancers, multiple myeloma (MM), various autoimmune diseases, etc. * Participants with clinically significant or abnormal laboratory parameters (serum creatinine, SGPT, AST, serum electrolytes) in the opinion of the investigator. * Any condition that presents an unacceptable risk of injury, as assessed by the site investigator * Subjects planning to have surgery in the 3 months preceding the completion of the project * Subjects concurrently using anti-malarial drugs * Any condition that, in the researcher's opinion, would jeopardize the safety or rights of the subject or prevent the subject from completing the procedures of the study protocol * Subjects exposed to any rabid animal bite in the 4 weeks preceding the commencement of the study. * Subjects with Type I or Type II Diabetes, as assessed by Random Blood Sugar level. * All research facility staff directly participating in this study, including their immediate family and relatives.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Infectious Disease and Tropical Medicine Department (Surya Kanta Hospital), Mymensingh Medical College Hospital, Mymensingh
Mymensingh, 2200, Bangladesh
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Experimental antibody cocktail offers hope for rabies patients with no other options
- New antibody cocktail aims to stop rabies after multiple dog bites
- New vaccines for yellow fever and rabies enter first human tests
- New rabies vaccine shows promise in large trial
- New rabies shot shows promise in preventing deadly infection after bites
- New rabies vaccine passes first safety check in small trial