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New MRI scan could replace liver biopsies for iron overload patients

NCT ID NCT04171635

Diagnosis Sponsor: Weill Medical College of Cornell University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new MRI technique called QSM to measure iron levels in the liver more accurately than current methods. Researchers compared MRI results from 55 patients before liver transplant with chemical analysis of their removed livers. The goal is to improve diagnosis and treatment of iron overload without needing a liver biopsy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

55 people

The number who actually took part.

Started

Dec 2019

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Healthy subjects will be selected from the community through personal contact and written description of the research, and online advertising. Subjects will be selected at Columbia from those awaiting liver transplant to be enrolled in the study.

Ages

2 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Established diagnosis of thalassemia major * Treatment with deferasirox formulated as Jadenu® as the sole iron chelating therapy (ICT) * Regular transfusion with records maintained in the Cornell Thalassemia Program * 2 years of age or older * Females who are not pregnant Inclusion Criteria (for healthy subjects): * Men and women aged 21 years or older * Able and willing to give consent * No known hematological and liver disease * No contraindications for MRI Exclusion Criteria: * A history of auditory or ocular toxicity related to ICT * A history of poor adherence to prescribed therapy * An inability to tolerate MRI examinations * Treatment for mental illness * Institutionalization or imprisonment

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Conditions

The condition(s) this trial relates to.

beta thalassemia Iron Overload

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mri scans

Contacts and locations

Locations

  • Columbia University Medical Center

    New York, New York, 10032, United States

  • Weill Cornell Medical College

    New York, New York, 10021, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.