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Can a targeted nerve procedure ease Post-Stroke shoulder pain?
NCT ID NCT07753759
First seen Aug 07, 2026 · Last updated Aug 07, 2026
Summary
This trial tests two ultrasound-guided procedures to relieve shoulder pain that often follows a stroke. One uses pulsed radiofrequency to modulate nerve activity, while the other uses a phenol injection to temporarily block nerves. The study includes adults with post-stroke hemiplegic shoulder pain and aims to see which approach better reduces pain, improves shoulder function and quality of life, and has fewer side effects over six months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Pulsed radiofrequency neuromodulation or phenol neurolysis, both delivered via ultrasound guidance to shoulder nerves
- What this could lead to
- If successful, this could point toward a better, longer-lasting way to relieve post-stroke shoulder pain and improve arm function and quality of life.
- What could go wrong
- This is a relatively small trial, and results may not apply to everyone. Both procedures carry risks like pain, bleeding, or nerve damage, and the phenol injection may cause more side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 70 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Feb 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged 18 years or older. History of ischemic or hemorrhagic stroke confirmed clinically and/or by neuroimaging when available. Post-stroke shoulder pain on the hemiplegic side with VAS pain intensity \>=4/10 during rest, passive movement or functional use. Spasticity of target shoulder-girdle muscles with MAS score \>=2. Stable medical condition allowing outpatient or inpatient interventional procedure. Ability to provide written informed consent; if the patient has a communication impairment, consent will follow institutional ethics-approved procedures involving legally authorized representatives when appropriate. Expected ability to attend scheduled follow-up visits through 6 months Exclusion Criteria: * Previous radiofrequency treatment or phenol neurolysis to the affected shoulder within the previous 6 months. Botulinum toxin injection to the target shoulder muscles within the previous 3-6 months. Shoulder fracture, dislocation or rotator cuff tear requiring surgery. Active infection at the injection site. Known allergy or contraindication to phenol, local anesthetic, antiseptic solution or other procedure-related medication. Coagulopathy, platelet disorder or anticoagulant/antiplatelet treatment that cannot be safely managed according to local anesthesia/interventional-pain policy. Severe uncontrolled medical illness, unstable cardiopulmonary disease, uncontrolled diabetes with active infection risk, or any condition judged by investigators to increase procedural risk. Severe cognitive, behavioral, or communication impairment preventing reliable pain/outcome assessment unless a validated caregiver-assisted assessment approach is approved by the ethics committee. Pregnancy or lactation, when applicable, because of procedural medication exposure and safety monitoring requirements. Concurrent participation in another interventional trial that may affect shoulder pain, tone or function.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.