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Leg lift test may help ICU doctors avoid unnecessary fluids

NCT ID NCT06480942

Diagnosis Sponsor: CHU de Reims Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether changes in pulse pressure during a passive leg raise can predict if a patient needs fluids. Researchers included 39 spontaneously breathing ICU patients with signs of low blood flow. They measured pulse pressure and its variation before and after a leg raise, comparing results to heart ultrasound. The goal was to find a simple, non-invasive way to guide fluid therapy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could give doctors a simple, non-invasive way to decide which ICU patients need fluids, avoiding unnecessary harm.
What could go wrong
This is a small, completed study with only 39 patients, so results may not apply to all ICU patients. The method needs more testing before routine use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

39 people

The number who actually took part.

Started

Oct 2023

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

* Patient over 18 years old. * Hospitalized in intensive care. * For which the clinician in charge of the patient will need to predict the response to fluids and decide on a possible infusion of fluids, because of: * Acute circulatory failure with mean arterial pressure \< 65mmHg or \< 30mmHg of its baseline value for hypertensive patients. * And/or other signs of hemodynamic instability (tachycardia, mottling, oliguria, hyperlactatemia) : * In spontaneous ventilation and without ventilatory assistance. * Previously equipped with an arterial catheter. * Affiliated to a social security scheme.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient over 18 years old. * Hospitalized in intensive care. * For which the clinician in charge of the patient will need to predict the response to fluids and decide on a possible infusion of fluids, because of: * Acute circulatory failure with mean arterial pressure \< 65mmHg or \< 30mmHg of its baseline value for hypertensive patients. * And/or other signs of hemodynamic instability (tachycardia, mottling, oliguria, hyperlactatemia) : * In spontaneous ventilation and without ventilatory assistance. * Previously equipped with an arterial catheter. * Affiliated to a social security scheme. Exclusion Criteria: * Patient with arrythmia (PPV is not applicable). * Patient with intra-abdominal hypertension (PLR test is not valid). * Patient with a contraindication/impossibility to the PLR maneuver (lower limb amputation, respiratory intolerance). * Patient with poor echogenicity noted previously. * Patient protected by law.

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Conditions

The condition(s) this trial relates to.

Hypovolemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypovolemia

Contacts and locations

Locations

  • Chu Reims

    Reims, 51092, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.