Brain zaps boost PTSD therapy? tiny study hints at hope
NCT ID NCT06271733
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tested whether adding a type of brain stimulation called TMS to an intensive 2-week PTSD program could improve symptoms in veterans. Six participants received daily TMS sessions alongside their regular therapy. The study measured changes in PTSD and depression symptoms using standard questionnaires.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- transcranial magnetic stimulation (TMS)
- What this could lead to
- If it works, this could point toward a faster, more effective way to treat PTSD by adding brain stimulation to intensive therapy.
- What could go wrong
- This is a very small pilot study with only 6 participants, so results may not apply to everyone. It is too early to know if the combination is truly better than therapy alone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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6 people
The number who actually took part.
- Started
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Jan 2022
- Finished
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Oct 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 65 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Veterans or service members between the ages of 18 and 65 who are attending the 2- week Intensive Outpatient Program at the Road Home Program and have not had significant PTSD symptom change based on the PCL-5 during the first week of treatment. * Participants with an HDRS-21 score ≤ 26 at screening visit Exclusion Criteria: * Individuals with implants and non-removable metals which prevent them from safely receiving TMS, including: * Aneurysm clips or coils * Stents in the head, neck, or brain * Deep brain stimulators * Metallic implants in the head, neck, or brain (braces and dental implants do not interfere and are safe for TMS) * Shrapnel or bullet fragments in or near the head * Facial tattoos with metallic or magnetic-sensitive ink * Other metal devices or ferromagnetic objects implanted in or near the head * Pacemakers, intra-cardiac lines, or implanted medical pumps * Individuals with a history of seizures or epilepsy (except those therapeutically induced by ECT) * Individuals diagnosed with major, chronic mental health illnesses such as Psychotic Disorders, Bipolar Disorders, and Obsessive Compulsive Disorder * Individuals with a history of substance abuse within the past six months * Individuals with significant neurological disorders such as Parkinson's disease, Huntington's chorea, and Multiple sclerosis * Individuals with unstable physical disease, such as unstable cardiac diseases * Individuals currently on Benzodiazepine at a dose higher than 3mg or Lorazepam or equivalent. * Women who are breastfeeding or pregnant * Individuals with previous TMS treatment
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Rush University Medical Center
Chicago, Illinois, 60612, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a therapist on a screen ease both trauma and pain?
- Zapping the Brain's fear hub: a new hope for PTSD?
- Can a drug combo or therapy dogs ease PTSD?
- Can six short writing sessions ease PTSD in underserved patients?
- Can a psychedelic compound help veterans and first responders with PTSD and alcohol use disorder?