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Brain zaps boost PTSD therapy? tiny study hints at hope

NCT ID NCT06271733

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested whether adding a type of brain stimulation called TMS to an intensive 2-week PTSD program could improve symptoms in veterans. Six participants received daily TMS sessions alongside their regular therapy. The study measured changes in PTSD and depression symptoms using standard questionnaires.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial magnetic stimulation (TMS)
What this could lead to
If it works, this could point toward a faster, more effective way to treat PTSD by adding brain stimulation to intensive therapy.
What could go wrong
This is a very small pilot study with only 6 participants, so results may not apply to everyone. It is too early to know if the combination is truly better than therapy alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

6 people

The number who actually took part.

Started

Jan 2022

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Veterans or service members between the ages of 18 and 65 who are attending the 2- week Intensive Outpatient Program at the Road Home Program and have not had significant PTSD symptom change based on the PCL-5 during the first week of treatment. * Participants with an HDRS-21 score ≤ 26 at screening visit Exclusion Criteria: * Individuals with implants and non-removable metals which prevent them from safely receiving TMS, including: * Aneurysm clips or coils * Stents in the head, neck, or brain * Deep brain stimulators * Metallic implants in the head, neck, or brain (braces and dental implants do not interfere and are safe for TMS) * Shrapnel or bullet fragments in or near the head * Facial tattoos with metallic or magnetic-sensitive ink * Other metal devices or ferromagnetic objects implanted in or near the head * Pacemakers, intra-cardiac lines, or implanted medical pumps * Individuals with a history of seizures or epilepsy (except those therapeutically induced by ECT) * Individuals diagnosed with major, chronic mental health illnesses such as Psychotic Disorders, Bipolar Disorders, and Obsessive Compulsive Disorder * Individuals with a history of substance abuse within the past six months * Individuals with significant neurological disorders such as Parkinson's disease, Huntington's chorea, and Multiple sclerosis * Individuals with unstable physical disease, such as unstable cardiac diseases * Individuals currently on Benzodiazepine at a dose higher than 3mg or Lorazepam or equivalent. * Women who are breastfeeding or pregnant * Individuals with previous TMS treatment

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Rush University Medical Center

    Chicago, Illinois, 60612, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.