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New pill shows promise for psoriasis in early trial

NCT ID NCT06176768

First seen Nov 01, 2025 · Last updated Jun 20, 2026 · Updated 35 times

Summary

This phase 2 trial tested an oral drug called LY3972406 in 33 adults with moderate-to-severe plaque psoriasis. The study compared the drug to a placebo to see if it could reduce skin symptoms. Results will help determine if larger studies are warranted.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Accellacare - Winston-Salem

    Winston-Salem, North Carolina, 27103, United States

  • Austin Institute for Clinical Research

    Houston, Texas, 77056, United States

  • Center for Clinical Studies

    Houston, Texas, 77004, United States

  • Clinical Science Institute

    Santa Monica, California, 90404, United States

  • Conquest Research

    Winter Park, Florida, 32789, United States

  • DermDox Centers for Dermatology

    Camp Hill, Pennsylvania, 17011, United States

  • Dermatology Research Associates

    Los Angeles, California, 90045, United States

  • Driven Research

    Coral Gables, Florida, 33134, United States

  • Metropolitan Dermatology - Clark

    Kenilworth, New Jersey, 07033, United States

  • Psoriasis Treatment Center of Central New Jersey

    East Windsor, New Jersey, 08520, United States

  • Remington-Davis, Inc

    Columbus, Ohio, 43215, United States

  • Schweiger Dermatology Group

    Hackensack, New Jersey, 07601, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

LY3972406 (oral drug)

What this could lead to

If successful, this could lead to a new oral treatment option for moderate-to-severe plaque psoriasis.

What could go wrong

This is a small, early-phase trial with only 33 participants. The drug may not prove effective or safe in larger studies.

Conditions

The condition(s) this trial relates to.

psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.