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Proton vs. photon: which radiation works better for advanced lung cancer?

NCT ID NCT01993810

First seen May 20, 2026 · Last updated May 20, 2026

Summary

This study tested whether proton radiation therapy combined with chemotherapy helps people with inoperable stage II-IIIB non-small cell lung cancer live longer compared to standard photon radiation therapy. About 330 adults took part. The goal was to see which approach better controls the cancer while reducing damage to healthy tissue.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Central Maryland Radiation Oncology in Howard County

    Columbia, Maryland, 21044, United States

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

  • MD Anderson Regional Care Center-Bay Area

    Nassau Bay, Texas, 77058, United States

  • MD Anderson Regional Care Center-Katy

    Houston, Texas, 77094, United States

  • MD Anderson Regional Care Center-Sugar Land

    Sugar Land, Texas, 77478, United States

  • MD Anderson Regional Care Center-The Woodlands

    The Woodlands, Texas, 77384, United States

  • Maryland Proton Treatment Center

    Baltimore, Maryland, 21201, United States

  • Mass General/North Shore Cancer Center

    Danvers, Massachusetts, 01923, United States

  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts, 02114, United States

  • Memorial Sloan Kettering Basking Ridge

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Commack

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Rockville Centre

    Rockville Centre, New York, 11570, United States

  • Memorial Sloan Kettering Sleepy Hollow

    Sleepy Hollow, New York, 10591, United States

  • Memorial Sloan Kettering Westchester

    Harrison, New York, 10604, United States

  • Northwestern Medicine Cancer Center Warrenville

    Warrenville, Illinois, 60555, United States

  • ProCure Proton Therapy Center-Seattle

    Seattle, Washington, 98133, United States

  • ProCure Proton Therapy Center-Somerset

    Somerset, New Jersey, 08873, United States

  • Siteman Cancer Center at West County Hospital

    Creve Coeur, Missouri, 63141, United States

  • Tate Cancer Center

    Glen Burnie, Maryland, 21061, United States

  • Tennessee Cancer Specialists-Dowell Springs

    Knoxville, Tennessee, 37909, United States

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • University of Cincinnati Medical Center

    Cincinnati, Ohio, 45267, United States

  • University of Florida Health Science Center - Jacksonville

    Jacksonville, Florida, 32209, United States

  • University of Maryland/Greenebaum Cancer Center

    Baltimore, Maryland, 21201, United States

  • University of Pennsylvania/Abramson Cancer Center

    Philadelphia, Pennsylvania, 19104, United States

  • University of Washington Medical Center

    Seattle, Washington, 98195, United States

  • Upper Chesapeake Medical Center

    Bel Air, Maryland, 21014, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • West Chester Hospital

    West Chester, Ohio, 45069, United States

Conditions

Explore the condition pages connected to this study.