Can a Pea-Coated probiotic boost your gut bugs?
NCT ID NCT07510282
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early study tests whether wrapping a probiotic (L. rhamnosus) in pea-protein capsules helps it reach the small intestine and grow. Twenty-five healthy adults will drink a yogurt beverage with or without the probiotic for 28 days, and researchers will track bacteria in stool samples over 70 days. The goal is to understand how targeted delivery affects gut microbes, not to treat any disease.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Probiotic containing L. rhamnosus R0011 strain
- What this could lead to
- If it works, this could point toward better ways to deliver probiotics for gut health.
- What could go wrong
- This is a very early, small study (25 people) looking at bacteria levels, not health outcomes. It may not show any meaningful effect.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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About 25 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Apr 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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25 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Capacity to obtain and sign informed consent before any study-related procedure * BMI range 18.5-31.9 kg/m2 * Willing to abstain from regular consumption of probiotic supplements or food products containing probiotic bacteria (including fermented food and beverages). * Willing to abstain from regular consumption of supplements and medications known to alter gastrointestinal function or inflammatory status during the study. Exclusion Criteria: * Smoking * Substance abuse * Pregnancy * Diagnosis of type 1 and/or type 2 diabetes * Current (or within the last 4 weeks prior to the study start) use of probiotic supplementation. * Immobile (defined as the inability to participate in all study-related procedures) * History of complicated gastrointestinal surgery * Diagnosed with inflammatory bowel disease (IBD) * Current diagnosis of psychiatric disease/s or syndromes * Current diagnosis of neurodegenerative disease * Systemic use of antibiotics and/or steroid medication in the last 4 months prior to inclusion * Use of any non-steroidal anti-inflammatory drug (NSAID) more than 3 times a week for the last 2 months * Consumption of any NSAID within 7 days of study start * Any condition which could substantially interfere with intestinal barrier function (e.g. gluten sensitivity, lactose intolerance, celiac disease, IBS, IBD) or in any other way with the outcome of the study, as decided by the principal investigator's discretion * Regular smoking, use of snuff, nicotine, cannabidiol narcotics/supplements, or e-cigarette use * Drinking more than 9 standard cups of alcohol per week and/or more than 3 standard cups of alcohol per occasion * Regular use, for more than three times a week for the last 2 months and/or 7 days prior to inclusion, of medications which, according to the principal investigator, can have an anti-inflammatory effect or affect in any way the intestinal barrier function or have an impact on the study analysis (such as laxatives, anti-diarrheal, anti-cholinergic, etc.) * After being included in the study, starting any medication or treatment that could potentially influence the study participation and/or study analysis.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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