Could probiotics ease lactose intolerance? small study investigates
NCT ID NCT07652827
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a daily probiotic capsule containing two bacterial strains could reduce gastrointestinal symptoms like bloating, gas, and cramps in adults with lactose intolerance and methanogenic intestinal overgrowth. Twenty-two adults took either the probiotic or a placebo for 12 weeks. The goal was to see if the probiotic could improve symptoms and breath test results.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Probiotic formulation (Lacticaseibacillus rhamnosus and Limosilactobacillus fermentum)
- What this could lead to
- If it works, this could point toward a probiotic supplement to reduce bloating, gas, and other digestive discomfort in people with lactose intolerance.
- What could go wrong
- This was a very small pilot study with only 22 participants, so results may not apply to everyone. The probiotic may not work better than a placebo, and more research is needed.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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22 people
The number who actually took part.
- Started
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Aug 2024
- Finished
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Jan 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Be of legal age (18 years or older) * Have a confirmed diagnosis of lactose intolerance * Currently consume dairy products or derivatives, with or without lactose (which is why the participants' diets were not modified) Exclusion Criteria: * Use of probiotics, antibiotics, laxatives, enemas, or prokinetic agents within 1 to 4 weeks prior to the start of the intervention. * Regular use and/or consumption of lactase enzymes for digestive support within 2 to 4 weeks prior to the start of the intervention. * Participation in another intervention for the symptomatic management of lactose intolerance. * Pregnant or breastfeeding women. * Adults with significant gastrointestinal disease (inflammatory bowel disease, celiac disease, chronic diarrhea, gastroparesis, and gastroenteritis). * Those who have undergone gastrointestinal surgery within the 6 months prior to the start of the study. * Individuals with an allergy to any of the excipients included in the probiotic formulation or placebo. * Individuals with diabetes, whether insulin-dependent or non-insulin-dependent. * Individuals with cardiac stimulation devices (pacemakers).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Universidad de Concepción
Concepción, 4030000, Chile
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