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Can a simple CT scan replace an invasive heart test before valve replacement?

NCT ID NCT05750173

Knowledge-focused Sponsor: Institut für Pharmakologie und Präventive Medizin Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 150 older adults (75+) getting a new heart valve. It compared using a CT scan versus an invasive angiogram to check for blocked arteries beforehand. The goal was to see if the CT scan alone is safe and works just as well, potentially simplifying the process.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

150 people

The number who actually took part.

Started

Sep 2023

Finished

Mar 2026

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Investigational CTA-only phase: 100 consecutive patient who have not already been diagnosed with significant (≥50%) left main coronary artery (LM) or proximal stenosis of the left anterior descending artery (LAD) ans who have not previously undergone coronary revascularisation. CTA+ICA control phase: 50 consecutive patients who have not alreeady been diagnosed with significant (≥50%) left main coronary artery (LM) / proximal LAD stenosis and who have not previously undergone coronary revascularisation and will undergo CTA. If LM/ proximal LAD stenosis of (≥50%) can be ruled out and ICA is also performed prior to TAVI these patients will serve as control group.

Ages

75 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Investigational CTA-only Cohort * Consecutive adult patients ≥ 75 years * Consecutive patients with severe AS (symptomatic or asymptomatic) with a guideline-based indication to undergo implantation of a transcatheter heart valve of the SAPIEN family * Ability to undergo CTA * Patient is scheduled to undergo a 30 Day and 3 Months follow-up CTA+ICA control Cohort * Consecutive adult patients ≥ 75 years * Consecutive patients underwent implantation of a transcatheter heart valve of the SAPIEN family because of severe aortic stenosis * Ability to undergo CTA and ICA Exclusion Criteria: investigational CTA-only Cohort * Patients with already diagnosed proximal stenosis of the left anterior descending artery (LAD) OR the left main coronary artery (LM) ≥50% * Any prior coronary revascularization / prior aortic valve replacement * Life expectancy below 12 months * Lack of informed consent / data protection statement CTA+ICA control Cohort * Patients diagnosed with proximal stenosis of the left anterior descending artery (LAD) OR the left main coronary artery (LM) ≥50% already at baseline * Any prior coronary revascularization / prior aortic valve replacement * Life expectancy below 12 months * Lack of informed consent / data protection statement

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Transcatheter aortic valve implantation (TAVI)

Contacts and locations

Locations

  • Klinik Floridsdorf

    Vienna, 1210, Austria

  • Medical University of Vienna

    Vienna, 1090, Austria

  • University Clinic St. Pölten

    Sankt Pölten, 3100, Austria

  • University Hospital Bochum / HDZ NRW

    Bad Oeynhausen, North Rhine-Westphalia, 32545, Germany

  • University Hospital of the Bergmannsheil gGmbH

    Bochum, North Rhine-Westphalia, 44789, Germany

  • Universitätsklinik für Innere Medizin III - Kardiologie und Angiologie

    Innsbruck, Tyrol, 6020, Austria

More trials for these conditions

Other studies related to the condition(s) this trial covers.