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New asthma pill shows promise in Mid-Stage trial

NCT ID NCT05851443

Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times

Summary

This study tests an experimental drug called povorcitinib in 240 adults with moderate to severe asthma that is not well controlled by current treatments. Participants will receive one of three doses of the drug or a placebo for 24 weeks. The main goal is to see if the drug improves lung function and reduces asthma attacks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

247 people

The number who actually took part.

Started

Jul 2023

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Physician-diagnosed asthma requiring treatment with medium- to high-dose ICS-LABA for at least 12 months prior to screening. * Pre-BD FEV1 \< 80% predicted according to central over read value at Visit 2. * Documented historical post-BD reversibility of FEV1 ≥ 12% and ≥ 200 mL in FEV1. * At least 2 documented asthma exacerbations (requiring treatment with systemic CS, hospitalization, or emergency department visit) within 12 months prior to screening but not within the past 4 weeks prior to screening * ACQ-6 ≥ 1.5 at screening. Exclusion Criteria: * Maintenance use of asthma controllers other than ICS-LABA. * Have undergone bronchial thermoplasty. * Current smokers or participants with a smoking history of ≥ 10 pack-years and participants using vaping products, including electronic cigarettes. * Women who are pregnant (or who are considering pregnancy) or breastfeeding. * Current conditions or history of other diseases, as follows: * Clinically important pulmonary disease other than asthma ,Thrombocytopenia, coagulopathy, or platelet dysfunction. * Venous and arterial thrombosis, deep vein thrombosis, pulmonary embolism, moderate to severe heart failure (NYHA Class III or IV), cerebrovascular accident, myocardial infarction, coronary stenting, or CABG surgery. * Diagnosis of other significant cardiovascular diseases, including but not limited to angina, peripheral arterial disease, or uncontrolled arrhythmias such as atrial fibrillation, supraventricular tachycardia, ventricular tachycardia, and forms of carditis. * Recipient of an organ transplant that requires continued immunosuppression. * Immunocompromised (eg, lymphoma, acquired immunodeficiency syndrome, Wiskott-Aldrich syndrome). * Any malignancies or history of malignancies. * Chronic or recurrent infectious disease. * Receipt of any biologic drugs used for asthma \< 12 weeks or 5 half-lives (if known), whichever is longer, prior to screening

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Conditions

The condition(s) this trial relates to.

asthma chronic asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Moderate to severe asthma

Contacts and locations

Locations

  • Aa Medical Research Center

    Flint, Michigan, 48504, United States

  • Advanced Clinical Research Atlanta

    Atlanta, Georgia, 30309, United States

  • Allergy Clinic Homeo Medicus

    Bialystok, 15-687, Poland

  • Allervie Clinical Research

    Birmingham, Alabama, 35209, United States

  • Anderson Allergy and Asthma

    Orlando, Florida, 32806, United States

  • Care Research Center, Inc

    Miami, Florida, 33175, United States

  • Care Research Inc

    Miami, Florida, 33130, United States

  • Care: Centro de Alergia Y Enfermedades Respiratorias

    CABA, C1414AIF, Argentina

  • Centre For Lung Health

    Vancouver, British Columbia, V5Z 1M9, Canada

  • Centro Medico Dharma

    Mendoza, 05500, Argentina

  • Centro Medico Respire

    San Fernando, 01644, Argentina

  • Centro Respiratorio Infantil

    Rosario, 02000, Argentina

  • Centro Respiratorio Quilmes

    Quilmes, 01878, Argentina

  • Centro de Medicina Respiratoria

    Concepción del Uruguay, 03260, Argentina

  • Cimer - Centro Integral de Medicina Respiratoria Srl

    San Miguel de Tucumán, T4000 CBC, Argentina

  • Clinical Research of Rock Hill

    Rock Hill, South Carolina, 29732, United States

  • Covenant Pulmonary Critical Care

    East Point, Georgia, 30344, United States

  • Direct Helpers Research Center

    Hialeah, Florida, 33012, United States

  • Dr. Syed Anees Medicine Professional Corporation

    Windsor, Ontario, N8X 1T3, Canada

  • Dr. de Armas Research Center, Llc

    Miami, Florida, 33174, United States

  • Dynamic Drug Advancement

    Ajax, Ontario, L1S2J5, Canada

  • Fukuwa Clinic

    Chūōku, 104-0031, Japan

  • Fundacion Cidea

    Buenos Aires, 1125 ABE, Argentina

  • Fundacion Enfisema

    Mar del Plata, B7612ENA, Argentina

  • Fundacion Respirar

    Buenos Aires, 01426, Argentina

  • Fundacion Scherbovsky

    Mendoza, M5500AXR, Argentina

  • Giromed Institute/ Clinica Tres Torrres

    Barcelona, 08017, Spain

  • Hannover Medical School

    Hanover, 30625, Germany

  • Henry Ford Hospital

    Detroit, Michigan, 48202, United States

  • Heuer Md Research Inc

    Orlando, Florida, 32819, United States

  • Hospital Clinic Barcelona Main

    Barcelona, 08036, Spain

  • Howland Allergy and Asthma Pllc Dba Orion Clinical Research

    Austin, Texas, 78759, United States

  • INAER

    Capitalfederal, C1425BEN, Argentina

  • INSARES

    Mendoza, MENDOZA (5500), Argentina

  • Iba Medica

    Santa Fe, S3000ASF, Argentina

  • Idaimae Minami Yojo Int Clinic

    Sapporo, 064-0804, Japan

  • Ierim Instituto de Enfermedades Respiratorias E Investigacion Medica

    San Juan Bautista, 01888, Argentina

  • Ikf Pneumologie Frankfurt, Clinical Research Center Respiratory Diseases

    Frankfurt am Main, 60596, Germany

  • Ikf Pneumologie Mainz

    Mainz, 55128, Germany

  • Instituto Especialidades de La Salud Rosario

    Rosario, 02000, Argentina

  • Instituto Medico de La Fundacion Estudios Clinicos

    Rosario, S2000 DEJ, Argentina

  • Instituto de Diagnostico Abc

    Rosario, 02000, Argentina

  • Instituto de Medicina Respiratoria - Imer

    Córdoba, X5003DCE, Argentina

  • Integrated Research of Inland, Inc

    Upland, California, 91786, United States

  • Ipr Instituto de Patologias Respiratorias

    San Miguel de Tucumán, 04000, Argentina

  • Kaiseikai Kita Shin Yokohama Internal Medicine Clinic

    Yokohama, 223-0059, Japan

  • Kern Allergy Medical Clinic, Inc

    Bakersfield, California, 93301, United States

  • Kirigaoka Tsuda Hospital

    Kitakyushu-shi, 802-0052, Japan

  • Kishiwada City Hospital

    Kishiwada, 596-8501, Japan

  • Kouwa Clinic

    Toshima-ku, 170-0003, Japan

  • Kyosokai Amc Nishi-Umeda Clinic

    Osaka, 530-0001, Japan

  • Lee Clinic

    Osaka, 531-0073, Japan

  • Linq Research, Llc

    Pearland, Texas, 77584, United States

  • Local Independent Administrative Institution Mie Prefectural General Medical Center

    Yokkaichi-shi, 510-8561, Japan

  • Mautalen Salud E Investigacion

    Buenos Aires, C1128AAF, Argentina

  • Montefiore Medical Center (Mmc)

    The Bronx, New York, 10461, United States

  • National Hospital Organization Fukuoka National Hospital

    Fukuoka, 811-1394, Japan

  • Nihonbashi Medical and Allergy Clinic

    Chūōku, 103-0022, Japan

  • Northshore Medical Group

    Glenview, Illinois, 60026, United States

  • Northwell Health Physician Partners

    New Hyde Park, New York, 11040, United States

  • Nzoz Atopia

    Krakow, 31-142, Poland

  • Onsite Clinical Solutions, Llc Charlotte Central Office

    Charlotte, North Carolina, 28277, United States

  • Ostrowieckie Centrum Medyczne Spka Cywilna Anna Olech-Cudzik Krzysztof Cudzik

    Ostrowiec Świętokrzyski, 27-400, Poland

  • Ottawa Allergy Research Corporation

    Ottawa, Ontario, K1H 1E4, Canada

  • Pim Mswia

    Warsaw, 02-507, Poland

  • Pioneer Clinical Research Ny

    New York, New York, 10016, United States

  • Pneumologische Gemeinschaftspraxis Kroker-Schaeben-Schmidt

    Bendorf, 56170, Germany

  • Polo de Salud Vistalba

    Mendoza, 05509, Argentina

  • Quality Assurance Research Center

    San Antonio, Texas, 78212, United States

  • Qway Research

    Hialeah, Florida, 33010, United States

  • Revive Research Institute

    Southfield, Michigan, 48075, United States

  • S. Fikry Medicine Professional Corporation

    Waterloo, Ontario, N2J 1C4, Canada

  • Sakaide City Hospital

    Sakaide-shi, 762-8550, Japan

  • Synergy Respiratory Care

    Sherwood Park, Alberta, T8H 0N2, Canada

  • Szpital Specjalistyczny Cdt Medicus

    Lubin, 59-300, Poland

  • Takahashi Medical Clinic

    Tokyo, 185-0014, Japan

  • Temple University Hospital

    Philadelphia, Pennsylvania, 19140, United States

  • Tohno Chuo Clinic

    Mizunami-shi, 509-6134, Japan

  • Tokyo Shinagawa Hospital

    Shinagawa-ku, 140-8522, Japan

  • Universitatsklinikum Bonn Aoer

    Bonn, 53127, Germany

  • Uniwersyteckie Centrum Kliniczne

    Gdansk, 80-214, Poland

  • Verus Clinical Research Corp

    Miami, Florida, 33135, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.