New POTS drug shows promise in early trial

NCT ID NCT06593600

Ongoing Symptom relief Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 39 times

Summary

This study tests an experimental drug called REGN7544 in 82 adults with Postural Orthostatic Tachycardia Syndrome (POTS). The goal is to see if a single dose can safely reduce the abnormal heart rate increase that happens when standing up. Researchers will also monitor side effects and how the drug moves through the body.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Indiana University Health Neuroscience Center

Indianapolis, Indiana, 46202, United States
Innovative Research of West Florida, Inc.

Clearwater, Florida, 33756, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Mercy Gilbert Medical Center

Gilbert, Arizona, 85297, United States
New York University Langone

New York, New York, 10016, United States
North County Neurology Associates

Carlsbad, California, 92011, United States
Saint Luke's MidAmerica Heart Institute

Kansas City, Missouri, 64111, United States
Southern California Heart Specialists

Pasadena, California, 91105, United States
Stanford University

Palo Alto, California, 94304, United States
University of Calgary

Calgary, Alberta, T2N 4Z6, Canada
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Texas Southwestern

Dallas, Texas, 75390, United States
University of Utah

Salt Lake City, Utah, 84108, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Yale University

New Haven, Connecticut, 06511, United States

Conditions

Explore the condition pages connected to this study.

POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME (POTS)