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New painkiller could cut opioid use after knee surgery

NCT ID NCT07430085

Symptom relief Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 07, 2026 · Updated 3 times

Summary

This study tests whether a long-acting painkiller (bupivacaine-meloxicam) can reduce pain and the need for opioid medications after robot-assisted knee replacement. 150 adults with knee osteoarthritis will receive either the new painkiller or a standard injection. Researchers will measure pain levels and opioid use for 72 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine-meloxicam extended-release solution
What this could lead to
If it works, this could offer a better way to manage pain after knee replacement, reducing the need for opioids.
What could go wrong
This is a small, early-phase study (Phase 4) with only 150 participants. The results may not apply to everyone, and there is a risk of side effects like allergic reactions or kidney problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 89 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Males or females aged 18-89 years Diagnosed with knee osteoarthritis requiring surgical intervention Indicated for unilateral RATKA Exclusion Criteria: Pediatric, pregnant, or incarcerated patients BMI of more than 45 kg/m2 Prolonged opioid use history of \>5 mg/day for \>1 month History of contralateral TKA \<2 years prior to the index TKA Type 1 Hypersensitivity to NSAIDs or local anesthetics Diagnosis of severe renal disease

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee periarthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee arthroplasty, total Osteoarthritis (OA) Osteoarthritis (OA) of the knee Pain after surgery Periarticular block

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.