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Concussion may raise risk of muscle injuries – study seeks answers

NCT ID NCT05122728

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to understand how a concussion changes the way people move, which may increase their risk of muscle and bone injuries. Researchers will compare movement patterns in 148 military members who have had a concussion with those who have not. The goal is to find specific movement problems that lead to injuries, so better prevention strategies can be developed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 148 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2022

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Concussed Cohort: Convenience sample of healthy active duty Service members and physically active civilians who self-report being asymptomatic following a concussion. Non-Concussed Cohort: Convenience sample of non-concussed matched active duty Service members and physically active civilians.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Concussed Cohort * 18-40 years old. * Self-reported asymptomatic post-concussion following enrollment into the study and monitoring of symptoms by research personnel via daily self-reported symptom questionnaires. * Recruited within 5 days following being diagnosed with a concussion, and at least 72 hours prior to self-reporting as asymptomatic. * Access to a functional email address and the internet for completion of patient reported outcomes (PROs) and musculoskeletal injury measures. Non-Concussed Cohort * 18-40 years old. * Active duty Service members and physically active civilians. * No self-report history of concussion within the previous 5 years. * No lingering post-concussion signs/symptoms. * Same gender as the matched concussed participant. * Within ±5% of the matched concussed participant's height, weight, and body mass index. * Within ±2 years of age of the matched concussed participant. * Participant in the same physical activities (work, recreational sports, average type \[no impact, low-impact, high-impact\] and duration of physical activity) Exclusion Criteria: * Post-Concussion Cohort AND Healthy Non-Concussed Cohort * Unable to read or comprehend the English language. * Admitted to the hospital following concussion. * Sustained a concussion not related to physical activity participation (e.g., blast-related injury, fall from a ladder, motor vehicle accident). * Loss of consciousness longer than 30 minutes. * Alteration in consciousness longer than 24 hours. * Post-traumatic amnesia lasting longer than 1 day. * Glasgow Coma Scale below 13. * Abnormal brain imaging findings. * Sustained a concussion that took longer than 21 days for the individual to report as asymptomatic. * A MSKI within the last 6 months that resulted in altered or missed physical activity for 3 or more consecutive days. * History of MSKI surgery. * Pregnant females (will be eligible for participation in the study once medically cleared to RTD/A by a qualified and licensed healthcare provider following the end of the pregnancy). * Participants will be excluded if they present any known contraindications for electrical stimulation. These contraindications include conditions such as: active deep vein thrombosis/thrombophlebitis, any acute injury with concurrent inflammation, hemorrhagic conditions, impaired circulation, impaired local sensations, presence of infection (osteomyelitis, tuberculosis), malignancy, recently radiated tissue, skin disease/damage and/or at-risk skin. * Present with any implanted pacemaker, electronic device, or plastic/cement material

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Conditions

The condition(s) this trial relates to.

Brain Concussion Brain Injuries, Traumatic injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Georgia

    RECRUITING

    Athens, Georgia, 30602, United States

  • Walter Reed National Military Medical Center

    RECRUITING

    Bethesda, Maryland, 20814, United States

  • Womack Army Medical Center

    ACTIVE_NOT_RECRUITING

    Fort Bragg, North Carolina, 28310, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.