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Gut-Brain fix for hot flushes? small study tests polyphenols & probiotics

NCT ID NCT06333223

Symptom relief Sponsor: University of Roehampton Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a combination of polyphenols (plant compounds) and probiotics (good bacteria) can improve menopause symptoms like hot flushes, low mood, and sleep trouble. Sixteen postmenopausal women took the supplement to see if it changed blood chemistry, body mass index, and gut bacteria. The goal was to find a natural way to ease symptoms by targeting the gut-brain connection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

16 people

The number who actually took part.

Started

Mar 2024

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

48 to 60 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults \>48 years * Post-menopausal female subjects without clinical signs or symptoms of cardiovascular disease, no menstruation cycle for more than 1 year, postmenopausal status conformed by female hormone analysis * For intervention purposes, eligible participants are also required to have a mobile phone and be able to read and speak English. Exclusion Criteria: * • People with comorbid conditions that may limit participation in the study, such as a history of an acute cardiovascular event, uncontrolled hypertension, cancer or major psychiatric or cognitive problems * People who are already participating in a weight loss programme * People receiving drug treatment for lipid metabolisms (e.g., statins * People with a history of long-term use of medicines known to influence glucose metabolism (e.g., corticosteroids) * People who take antibiotics or bacterial agents (Probiotics) within 1 month * Pregnant women, women ready for pregnancy, and nursing mothers * Post-menopausal female subjects without clinical signs or symptoms of cardiovascular disease * acute inflammation * cardiac arrhythmia * renal failure * heart failure (NYHA II-IV) * diabetes mellitus * C-reactive protein \> 0.5 mg/dL * malignant disease * hypotension (≤100 / 60 mm Hg) * Women who require hormone replacement therapy during the development of the protocol.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Menopause

Contacts and locations

Locations

  • Adele Costabile

    London, SW145JD, United Kingdom

  • Health Sciences Research Centre, Life Sciences Department, University of Roehampton

    London, UK, SW15 4JD, United Kingdom

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