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Promising new combo for aggressive blood cancer shows promise in large trial

NCT ID NCT03274492

First seen Nov 01, 2025 · Last updated May 18, 2026 · Updated 24 times

Summary

This large Phase 3 trial tested whether adding the targeted drug polatuzumab vedotin to standard chemotherapy (R-CHP) works better than the current standard (R-CHOP) for people with untreated diffuse large B-cell lymphoma, a common and aggressive blood cancer. About 1000 participants received either the new combination or the standard treatment, and researchers measured how long they lived without their cancer getting worse. The study aims to improve disease control, not cure, as ongoing management may still be needed.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AUSL di Reggio Emilia, IRCCS, P.O. Arcispedale Santa Maria Nuova

    Reggio Emilia, Emilia-Romagna, DUMMY_VALUE, Italy

  • Aichi Cancer Center

    Aichi, 464-8681, Japan

  • Ankara University Faculty of Medicine Cebeci Hospital

    Ankara, 06700, Turkey (Türkiye)

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Ashford Cancer Center Research

    Kurralta Park, South Australia, 5037, Australia

  • Asst Degli Spedali Civili Di Brescia

    Brescia, Abruzzo, 25123, Italy

  • Asst Papa Giovanni XXIII

    Bergamo, Abruzzo, 24127, Italy

  • Auckland City Hospital, Cancer and Blood Research

    Auckland, 1023, New Zealand

  • Austin Hospital

    Heidelberg, Victoria, 3084, Australia

  • Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino

    Turin, Piedmont, 10126, Italy

  • Azienda Ospedaliero Universitaria Maggiore della Carita di Novara

    Novara, Piedmont, 28100, Italy

  • BC Cancer Agency Vancouver Centre

    Vancouver, British Columbia, V5Z 4E6, Canada

  • Barts Health NHS Trust - St Bartholomew's Hospital

    London, EC1M 6BQ, United Kingdom

  • Beijing Cancer Hospital

    Beijing, 100142, China

  • CH Bretagne Atlantique

    Vannes, 56017, France

  • CH Jolimont - Lobbes (Jolimont)

    Haine-Saint-Paul, 7100, Belgium

  • CH Metropole de Savoie

    Chambéry, 73011, France

  • CHD Vendée

    La Roche-sur-Yon, 85025, France

  • CHU Amiens - Hopital Sud

    Amiens, 80054, France

  • CHU Angers

    Angers, 49933, France

  • CHU Bretonneau

    Tours, 37044, France

  • CHU Lyon Sud - Service Hématologie

    Pierre-Bénite, 69310, France

  • CHU Montpellier - Saint ELOI

    Montpellier, 34295, France

  • CHU UCL Mont-Godinne

    Mont-godinne, 5530, Belgium

  • CHU de Brabois

    Vandœuvre-lès-Nancy, 54511, France

  • CHU de Dijon - Hopital le Bocage

    Dijon, 21000, France

  • CHU de Nantes - Hotel Dieu

    Nantes, 44093, France

  • CHU de Nîmes - Hôpital Carémeau

    Nîmes, 30029, France

  • CHU de Poitiers

    Poitiers, 86021, France

  • CIUSSS de l Est de l Ile de Montreal - Hopital Maisonneuve Rosemont

    Montreal, Quebec, H1T 2M4, Canada

  • Calvary Mater Newcastle

    Waratah, New South Wales, 2298, Australia

  • Cambridge University Hospitals NHS Foundation Trust - Addenbrookes Hospital

    Cambridge, CB2 0QQ, United Kingdom

  • Cancer Trials New Zealand

    Hamilton, WKO, 3204, New Zealand

  • CancerCare Manitoba (CCMB)

    Winnipeg, Manitoba, MB R3E 0V9, Canada

  • Canterbury Health Laboratories

    Christchurch, 8011, New Zealand

  • Centre Antoine Lacassagne

    Nice, 06189, France

  • Centre Henri Becquerel

    Rouen, 76038, France

  • Centre Hospitalier de La Cote Basque

    Bayonne, 64109, France

  • Centre Hospitalier de Quimper Cornouaille (CHIC)

    Quimper, 29107, France

  • Centre Hospitalier de Saint Brieuc - Hôpital Yves Le Foll

    Saint-Brieuc, 22027, France

  • Centre Leon Berard

    Lyon, 69008, France

  • Centro de Hematologia e Hemoterapia - HEMOCENTRO UNICAMP

    Campinas, São Paulo, 13083-878, Brazil

  • Chi-Mei Hospital, Liouying

    Tainan, 736, Taiwan

  • Chiba Cancer Center

    Chiba, 260-8717, Japan

  • Chiba University Hospital

    Chūōku, 260-8670, Japan

  • China Medical University Hospital

    Taichung, 40447, Taiwan

  • Chru de Strasbourg

    Strasbourg, 67091, France

  • City of Hope

    Duarte, California, 91010, United States

  • Clinique Victor Hugo - Centre Jean Bernard

    Le Mans, 72015, France

  • Communal Institution 'Cherkassy Regional Oncology Dispensary' of the Cherkassy Regional Council

    Cherkassy, Chernihiv Governorate, DUMMY_VALUE, Ukraine

  • Complejo Hospitalario de Navarra

    Pamplona, Navarre, 31008, Spain

  • Concord Repatriation General Hospital

    Concord, New South Wales, 2139, Australia

  • Cross Cancer Institute

    Edmonton, Alberta, T6G 1Z2, Canada

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02115, United States

  • Dokuz Eylul Universitesi Tip Fakultesi

    Balçova, 35330, Turkey (Türkiye)

  • East Kent Hospitals University NHS Foundation Trust

    Canterbury, CT1 3NG, United Kingdom

  • Ege Üniversitesi Tip Fakültesi

    Lzmir, 35100, Turkey (Türkiye)

  • Emory University

    Atlanta, Georgia, 30322, United States

  • Fakultni Nemocnice Hradec Kralove (FNHK)

    Hradec Králové, 500 05, Czechia

  • Fakultni Nemocnice Kralovske Vinohrady (FNKV)

    Prague, 100 34, Czechia

  • Fakultní nemocnice Olomouc

    Olomouc, 779 00, Czechia

  • Florida Cancer Specialists & Research Institute

    St. Petersburg, Florida, 33705-1455, United States

  • Florida Cancer Specialists & Research Institute

    St. Petersburg, Florida, 33705, United States

  • Florida Cancer Specialists - Fort Myers (New Hampshire Ct)

    Fort Myers, Florida, 33901-8101, United States

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • Freeman Hospital

    Newcastle upon Tyne, NE7 7DN, United Kingdom

  • Fudan University Shanghai Cancer Center

    Shanghai, 200032, China

  • Fundación Jimenez Díaz

    Madrid, 28040, Spain

  • Georgetown University Medical Center

    Washington D.C., District of Columbia, 20007, United States

  • Gh Necker Enfants Malades

    Paris, 75743, France

  • Greco-Hainesworth Centers for Research

    Chattanooga, Tennessee, 37403, United States

  • Henan Cancer Hospital

    Zhengzhou, 450008, China

  • Hiroshima University Hospital

    Hiroshima, 734-8551, Japan

  • Hokkaido University Hospital

    Hokkaido, 060-8648, Japan

  • Hopital Claude Huriez

    Lille, 59037, France

  • Hopital Haut-Leveque - Centre Francois Magendie

    Pessac, 33604, France

  • Hopital Henri Mondor

    Créteil, 94010, France

  • Hopital Pontchaillou

    Rennes, 35033, France

  • Hopital Saint Jean

    Perpignan, 66046, France

  • Hopital Uni Ire Dupuytren

    Limoges, 87042, France

  • Hospital Clinic Barcelona

    Barcelona, 08036, Spain

  • Hospital Erasto Gaertner

    Curitiba, Paraná, 81520-060, Brazil

  • Hospital Quiron Madrid

    Madrid, 28233, Spain

  • Hospital San Pedro de Alcantara

    Cáceres, 10003, Spain

  • Hospital Universitari Dr. Josep Trueta

    Girona, 17007, Spain

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario La Paz

    Madrid, 280146, Spain

  • Hospital Universitario Virgen de la Victoria

    Málaga, 29010, Spain

  • Hospital Universitario Virgen del Rocío

    Seville, 41013, Spain

  • Hospital das Clinicas - FMUSP

    São Paulo, São Paulo, 05403-000, Brazil

  • Hospital de Clínicas de Porto Alegre X

    Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, 08041, Spain

  • Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Hôpital Albert Michallon

    La Tronche, 38700, France

  • Hôpital Saint Vincent de Paul

    Lille, 59000, France

  • Hôpital Saint-Louis

    Paris, 75475, France

  • Hôpital de l'Enfant-Jésus

    Québec, Quebec, G1J 1Z4, Canada

  • IRCCS AOU San Martino - IST

    Genoa, Liguria, 16132, Italy

  • Illinois Cancer Specialists

    Arlington Heights, Illinois, 60005, United States

  • InVO - Institut für Versorgungsforschung in der Onkologie GbR

    Koblenz, 56068, Germany

  • Institut Bergonie

    Bordeaux, 33076, France

  • Institut Catala d Oncologia Hospitalet

    L'Hospitalet de Llobregat, Barcelona, 08908, Spain

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Institut Universitaire du Cancer - Oncopole Toulouse (IUCT-O)

    Toulouse, 31059, France

  • Institut d'Hématologie de Basse Normandie

    Caen, 14000, France

  • Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences

    Tianjin, 300020, China

  • Istituto Nazionale dei Tumori

    Monza, Lombardy, 20052, Italy

  • James Graham Brown Cancer Center

    Louisville, Kentucky, 40202-3229, United States

  • Jiangsu Cancer Hospital

    Nanjing, 210009, China

  • Jichi Medical University Hospital

    Tochigi, 329-0498, Japan

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 807, Taiwan

  • Karmanos Cancer Center

    Detroit, Michigan, 48201, United States

  • Khmelnytskyi Regional Hospital

    Khmelnytskyi, Kharkiv Governorate, 29000, Ukraine

  • Kindai University Hospital

    Osaka, 589-8511, Japan

  • Kobe City Medical Center General Hospital

    Hyōgo, 650-0047, Japan

  • Kumamoto University Hospital

    Kumamoto, 860-8556, Japan

  • Kyushu University Hospital

    Fukuoka, 812-8582, Japan

  • L'Union Mutualiste de la Gestion des Eaux Claires - Institut Daniel Hollard

    Grenoble, 38000, France

  • Leningrad Regional Clinical Hospital

    Saint Petersburg, Sankt-Peterburg, 194291, Russia

  • Levine Cancer Institute - Clincal Trials Administration

    Charlotte, North Carolina, 28204, United States

  • MNE Lviv Territorial Medical Association Clinical Hospital for Palliative Care

    Lviv, Chernihiv Governorate, 79007, Ukraine

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Medical University of South Carolina (MUSC)

    Charleston, South Carolina, 29425, United States

  • Medizinische Universität Wien

    Vienna, 1090, Austria

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Cancer Center - Commack

    New York, New York, 10087-9049, United States

  • Memorial Sloan Kettering Cancer Center at Westchester

    Harrison, New York, 10604-3200, United States

  • Monash Medical Centre Clayton

    Clayton, Victoria, 3168, Australia

  • National Cancer Center

    Gyeonggi-do, 410-769, South Korea

  • National Cancer Center Hospital

    Tokyo, 104-0045, Japan

  • National Cancer Center Hospital East

    Chiba, 277-8577, Japan

  • National Hospital Organization Kyushu Cancer Center

    Fukuoka, 811-1395, Japan

  • National Taiwan University Hospital

    Taipei, 10002, Taiwan

  • New York University Cancer Cen

    New York, New York, 10016, United States

  • Northwest Cancer Specialists - Portland (SW Barnes Rd)

    Portland, Oregon, 97225, United States

  • Nottingham University Hospitals NHS Trust - City Hospital

    Nottingham, NG5 1PB, United Kingdom

  • Ochsner Medical Center

    New Orleans, Louisiana, 70121, United States

  • Oncology Associates of Oregon, P.C

    Eugene, Oregon, 97401, United States

  • Oncology Associates of Southwest Virginia, Inc.

    Blacksburg, Virginia, 24060, United States

  • Oncology Hematology Care

    Cincinnati, Ohio, 45242, United States

  • Oregon Health & Science University

    Portland, Oregon, 97239, United States

  • Osaka Metropolitan University Hospital

    Osaka, 545-8586, Japan

  • Oxford University Hospitals NHS Foundation Trust

    Oxford, OX3 7LE, United Kingdom

  • Paracelsus Medizinischen Privatuniversitaet-Salzburger Landeskliniken (SALK)

    Salzburg, 5020, Austria

  • Pratia Ma?opolskie Centrum Medyczne (MCM) Kraków

    Krakow, 30-727, Poland

  • Prince of Wales Hospital

    Randwick, New South Wales, 2031, Australia

  • Princess Alexandra Hospital Woolloongabba

    Woolloongabba, Queensland, 4102, Australia

  • Prisma Health ? Upstate

    Greenville, South Carolina, 29615, United States

  • Pusan National University Hospital

    Busan, 49241, South Korea

  • Pusan National University Yangsan Hospital

    Yangsan, 50612, South Korea

  • Pôle de Cancérologie ? CHU de Saint?Etienne'

    Saint-Priest-en-Jarez, 42270, France

  • Rocky Mountain Cancer Centers, LLP

    Aurora, Colorado, 80012, United States

  • Ronald Reagan UCLA Medical Center

    Los Angeles, California, 90024-6997, United States

  • Roswell Park Cancer Institute

    Buffalo, New York, 14263, United States

  • Ruijin Hospital, Shanghai Jiaotong University School of Medicine

    Shanghai, 200025, China

  • SPZOZ Ministerstwa Spraw Wewn?trznych i Administracji w Poznaniu

    Późna, 60-631, Poland

  • Samodzielny Publiczny Zak?ad Opieki Zdrowotnej Zespó? Szpitali Miejskich w Chorzowie

    Chorzów, 41-500, Poland

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Seattle Cancer Care Alliance

    Seattle, Washington, 98109, United States

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital

    Seoul, 03722, South Korea

  • Shanghai East Hospital, Tongji University

    Shanghai, 200120, China

  • Southern Cancer Center

    Daphne, Alabama, 36526, United States

  • St George Hospital

    Kogarah, New South Wales, 2217, Australia

  • Städtisches Klinikum Dessau

    Dessau, 06847, Germany

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario, M4N 3M5, Canada

  • Taipei Veterans General Hospital

    Taipei, 11211, Taiwan

  • Tennessee Oncology

    Nashville, Tennessee, 37203-1625, United States

  • Texas Oncology San Antonio Medical Center

    San Antonio, Texas, 78229, United States

  • Texas Oncology-Austin Midtown

    Austin, Texas, 78705, United States

  • Texas Oncology-Tyler

    Tyler, Texas, 75702, United States

  • The Cancer Institute Hospital of JFCR

    Tokyo, 135-8550, Japan

  • The Christie NHS Foundation Trust

    Manchester, M20 4BX, United Kingdom

  • The First Affiliated Hospital of College of Medicine, Zhejiang University

    Hangzhou, 310003, China

  • The First Hospital of Jilin University

    Changchun, 130021, China

  • The Johns Hopkins Hospital

    Baltimore, Maryland, 21205, United States

  • The Ohio State University Comprehensive Cancer Center

    Cleveland, Ohio, 44106, United States

  • The Ottawa Hospital

    Ottawa, Ontario, K1H 8L6, Canada

  • The University of Adelaide - The Queen Elizabeth Hospital (TQEH)

    Woodville South, South Australia, 5011, Australia

  • The University of Osaka Hospital

    Osaka, 565-0871, Japan

  • Tohoku University Hospital

    Miyagi, 980-8574, Japan

  • Tokai University Hospital

    Isehara-shi, 259-1193, Japan

  • UZ Gent

    Ghent, 9000, Belgium

  • Union Hospital Tongji Medical College Huazhong University of Science and Technology

    Wuhan, 430022, China

  • Universita degli Studi di Roma ''La Sapienza" - Clinica Ematologica

    Rome, Abruzzo, DUMMY_VALUE, Italy

  • Universitaetsklinikum Heidelberg

    Heidelberg, 69120, Germany

  • Universitatsklinikum Munster

    Münster, 48149, Germany

  • University Hospital Kyoto Prefectural University of Medicine

    Kyoto, 602-8566, Japan

  • University Hospitals Case Medical Center

    Cleveland, Ohio, 44106, United States

  • University Hospitals of Leicester NHS Trust - Leicester Royal Infirmary

    Leicester, LE1 5WW, United Kingdom

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35294, United States

  • University of Maryland

    Baltimore, Maryland, 21201, United States

  • University of Michigan Health System

    Ann Arbor, Michigan, 48109, United States

  • University of North Carolina School of Medicine

    Chapel Hill, North Carolina, 27514-4221, United States

  • University of Pittsburgh Cancer Institute

    Pittsburgh, Pennsylvania, 15232-1309, United States

  • University of Rochester Medical Center

    Rochester, New York, 14642, United States

  • University of Utah

    Salt Lake City, Utah, 84112, United States

  • Universitätsklinikum Essen

    Essen, 45147, Germany

  • Universitätsklinikum Halle (Saale)

    Halle, 6097, Germany

  • Universitätsspital Basel

    Basel, 4031, Switzerland

  • Uniwersytet Medyczny w Lodzi

    Lodz, 93-510, Poland

  • Virginia Cancer Specialists, PC

    Fairfax, Virginia, 22031-4618, United States

  • Vivantes Klinikum Am Urban

    Berlin, 10967, Germany

  • Všeobecná fakultní nemocnice v Praze

    Prague, 128 08, Czechia

  • Washington University

    St Louis, Missouri, 63110, United States

  • West Virginia Uni Med. Center - Robert Byrd Health Science

    Morgantown, West Virginia, 26505, United States

  • Westmead Hospital

    Westmead, New South Wales, 2145, Australia

  • Wiener Gesundheitsverbund ? Klinik Ottakring

    Vienna, 1160, Austria

  • Wojskowy Instytut Medyczny Centralny Szpital Kliniczny MON

    Warsaw, 04-359, Poland

Conditions

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