Promising new combo for aggressive blood cancer shows promise in large trial
NCT ID NCT03274492
First seen Nov 01, 2025 · Last updated May 18, 2026 · Updated 24 times
Summary
This large Phase 3 trial tested whether adding the targeted drug polatuzumab vedotin to standard chemotherapy (R-CHP) works better than the current standard (R-CHOP) for people with untreated diffuse large B-cell lymphoma, a common and aggressive blood cancer. About 1000 participants received either the new combination or the standard treatment, and researchers measured how long they lived without their cancer getting worse. The study aims to improve disease control, not cure, as ongoing management may still be needed.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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AUSL di Reggio Emilia, IRCCS, P.O. Arcispedale Santa Maria Nuova
Reggio Emilia, Emilia-Romagna, DUMMY_VALUE, Italy
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Aichi Cancer Center
Aichi, 464-8681, Japan
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Ankara University Faculty of Medicine Cebeci Hospital
Ankara, 06700, Turkey (Türkiye)
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Asan Medical Center
Seoul, 05505, South Korea
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Ashford Cancer Center Research
Kurralta Park, South Australia, 5037, Australia
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Asst Degli Spedali Civili Di Brescia
Brescia, Abruzzo, 25123, Italy
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Asst Papa Giovanni XXIII
Bergamo, Abruzzo, 24127, Italy
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Auckland City Hospital, Cancer and Blood Research
Auckland, 1023, New Zealand
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Austin Hospital
Heidelberg, Victoria, 3084, Australia
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Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino
Turin, Piedmont, 10126, Italy
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Azienda Ospedaliero Universitaria Maggiore della Carita di Novara
Novara, Piedmont, 28100, Italy
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BC Cancer Agency Vancouver Centre
Vancouver, British Columbia, V5Z 4E6, Canada
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Barts Health NHS Trust - St Bartholomew's Hospital
London, EC1M 6BQ, United Kingdom
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Beijing Cancer Hospital
Beijing, 100142, China
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CH Bretagne Atlantique
Vannes, 56017, France
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CH Jolimont - Lobbes (Jolimont)
Haine-Saint-Paul, 7100, Belgium
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CH Metropole de Savoie
Chambéry, 73011, France
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CHD Vendée
La Roche-sur-Yon, 85025, France
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CHU Amiens - Hopital Sud
Amiens, 80054, France
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CHU Angers
Angers, 49933, France
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CHU Bretonneau
Tours, 37044, France
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CHU Lyon Sud - Service Hématologie
Pierre-Bénite, 69310, France
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CHU Montpellier - Saint ELOI
Montpellier, 34295, France
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CHU UCL Mont-Godinne
Mont-godinne, 5530, Belgium
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CHU de Brabois
Vandœuvre-lès-Nancy, 54511, France
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CHU de Dijon - Hopital le Bocage
Dijon, 21000, France
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CHU de Nantes - Hotel Dieu
Nantes, 44093, France
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CHU de Nîmes - Hôpital Carémeau
Nîmes, 30029, France
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CHU de Poitiers
Poitiers, 86021, France
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CIUSSS de l Est de l Ile de Montreal - Hopital Maisonneuve Rosemont
Montreal, Quebec, H1T 2M4, Canada
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Calvary Mater Newcastle
Waratah, New South Wales, 2298, Australia
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Cambridge University Hospitals NHS Foundation Trust - Addenbrookes Hospital
Cambridge, CB2 0QQ, United Kingdom
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Cancer Trials New Zealand
Hamilton, WKO, 3204, New Zealand
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CancerCare Manitoba (CCMB)
Winnipeg, Manitoba, MB R3E 0V9, Canada
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Canterbury Health Laboratories
Christchurch, 8011, New Zealand
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Centre Antoine Lacassagne
Nice, 06189, France
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Centre Henri Becquerel
Rouen, 76038, France
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Centre Hospitalier de La Cote Basque
Bayonne, 64109, France
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Centre Hospitalier de Quimper Cornouaille (CHIC)
Quimper, 29107, France
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Centre Hospitalier de Saint Brieuc - Hôpital Yves Le Foll
Saint-Brieuc, 22027, France
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Centre Leon Berard
Lyon, 69008, France
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Centro de Hematologia e Hemoterapia - HEMOCENTRO UNICAMP
Campinas, São Paulo, 13083-878, Brazil
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Chi-Mei Hospital, Liouying
Tainan, 736, Taiwan
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Chiba Cancer Center
Chiba, 260-8717, Japan
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Chiba University Hospital
Chūōku, 260-8670, Japan
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China Medical University Hospital
Taichung, 40447, Taiwan
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Chru de Strasbourg
Strasbourg, 67091, France
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City of Hope
Duarte, California, 91010, United States
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Clinique Victor Hugo - Centre Jean Bernard
Le Mans, 72015, France
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Communal Institution 'Cherkassy Regional Oncology Dispensary' of the Cherkassy Regional Council
Cherkassy, Chernihiv Governorate, DUMMY_VALUE, Ukraine
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Complejo Hospitalario de Navarra
Pamplona, Navarre, 31008, Spain
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Concord Repatriation General Hospital
Concord, New South Wales, 2139, Australia
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Cross Cancer Institute
Edmonton, Alberta, T6G 1Z2, Canada
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Dana Farber Cancer Institute
Boston, Massachusetts, 02115, United States
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Dokuz Eylul Universitesi Tip Fakultesi
Balçova, 35330, Turkey (Türkiye)
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East Kent Hospitals University NHS Foundation Trust
Canterbury, CT1 3NG, United Kingdom
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Ege Üniversitesi Tip Fakültesi
Lzmir, 35100, Turkey (Türkiye)
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Emory University
Atlanta, Georgia, 30322, United States
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Fakultni Nemocnice Hradec Kralove (FNHK)
Hradec Králové, 500 05, Czechia
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Fakultni Nemocnice Kralovske Vinohrady (FNKV)
Prague, 100 34, Czechia
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Fakultní nemocnice Olomouc
Olomouc, 779 00, Czechia
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Florida Cancer Specialists & Research Institute
St. Petersburg, Florida, 33705-1455, United States
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Florida Cancer Specialists & Research Institute
St. Petersburg, Florida, 33705, United States
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Florida Cancer Specialists - Fort Myers (New Hampshire Ct)
Fort Myers, Florida, 33901-8101, United States
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
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Freeman Hospital
Newcastle upon Tyne, NE7 7DN, United Kingdom
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Fudan University Shanghai Cancer Center
Shanghai, 200032, China
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Fundación Jimenez Díaz
Madrid, 28040, Spain
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Georgetown University Medical Center
Washington D.C., District of Columbia, 20007, United States
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Gh Necker Enfants Malades
Paris, 75743, France
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Greco-Hainesworth Centers for Research
Chattanooga, Tennessee, 37403, United States
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Henan Cancer Hospital
Zhengzhou, 450008, China
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Hiroshima University Hospital
Hiroshima, 734-8551, Japan
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Hokkaido University Hospital
Hokkaido, 060-8648, Japan
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Hopital Claude Huriez
Lille, 59037, France
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Hopital Haut-Leveque - Centre Francois Magendie
Pessac, 33604, France
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Hopital Henri Mondor
Créteil, 94010, France
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Hopital Pontchaillou
Rennes, 35033, France
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Hopital Saint Jean
Perpignan, 66046, France
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Hopital Uni Ire Dupuytren
Limoges, 87042, France
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Hospital Clinic Barcelona
Barcelona, 08036, Spain
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Hospital Erasto Gaertner
Curitiba, Paraná, 81520-060, Brazil
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Hospital Quiron Madrid
Madrid, 28233, Spain
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Hospital San Pedro de Alcantara
Cáceres, 10003, Spain
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Hospital Universitari Dr. Josep Trueta
Girona, 17007, Spain
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Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitario La Paz
Madrid, 280146, Spain
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Hospital Universitario Virgen de la Victoria
Málaga, 29010, Spain
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Hospital Universitario Virgen del Rocío
Seville, 41013, Spain
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Hospital das Clinicas - FMUSP
São Paulo, São Paulo, 05403-000, Brazil
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Hospital de Clínicas de Porto Alegre X
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
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Hospital de la Santa Creu i Sant Pau
Barcelona, 08041, Spain
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Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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Hôpital Albert Michallon
La Tronche, 38700, France
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Hôpital Saint Vincent de Paul
Lille, 59000, France
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Hôpital Saint-Louis
Paris, 75475, France
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Hôpital de l'Enfant-Jésus
Québec, Quebec, G1J 1Z4, Canada
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IRCCS AOU San Martino - IST
Genoa, Liguria, 16132, Italy
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Illinois Cancer Specialists
Arlington Heights, Illinois, 60005, United States
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InVO - Institut für Versorgungsforschung in der Onkologie GbR
Koblenz, 56068, Germany
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Institut Bergonie
Bordeaux, 33076, France
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Institut Catala d Oncologia Hospitalet
L'Hospitalet de Llobregat, Barcelona, 08908, Spain
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Institut Gustave Roussy
Villejuif, 94805, France
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Institut Universitaire du Cancer - Oncopole Toulouse (IUCT-O)
Toulouse, 31059, France
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Institut d'Hématologie de Basse Normandie
Caen, 14000, France
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Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences
Tianjin, 300020, China
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Istituto Nazionale dei Tumori
Monza, Lombardy, 20052, Italy
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James Graham Brown Cancer Center
Louisville, Kentucky, 40202-3229, United States
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Jiangsu Cancer Hospital
Nanjing, 210009, China
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Jichi Medical University Hospital
Tochigi, 329-0498, Japan
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Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
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Karmanos Cancer Center
Detroit, Michigan, 48201, United States
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Khmelnytskyi Regional Hospital
Khmelnytskyi, Kharkiv Governorate, 29000, Ukraine
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Kindai University Hospital
Osaka, 589-8511, Japan
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Kobe City Medical Center General Hospital
Hyōgo, 650-0047, Japan
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Kumamoto University Hospital
Kumamoto, 860-8556, Japan
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Kyushu University Hospital
Fukuoka, 812-8582, Japan
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L'Union Mutualiste de la Gestion des Eaux Claires - Institut Daniel Hollard
Grenoble, 38000, France
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Leningrad Regional Clinical Hospital
Saint Petersburg, Sankt-Peterburg, 194291, Russia
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Levine Cancer Institute - Clincal Trials Administration
Charlotte, North Carolina, 28204, United States
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MNE Lviv Territorial Medical Association Clinical Hospital for Palliative Care
Lviv, Chernihiv Governorate, 79007, Ukraine
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Medical University of South Carolina (MUSC)
Charleston, South Carolina, 29425, United States
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Medizinische Universität Wien
Vienna, 1090, Austria
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Cancer Center - Commack
New York, New York, 10087-9049, United States
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Memorial Sloan Kettering Cancer Center at Westchester
Harrison, New York, 10604-3200, United States
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Monash Medical Centre Clayton
Clayton, Victoria, 3168, Australia
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National Cancer Center
Gyeonggi-do, 410-769, South Korea
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National Cancer Center Hospital
Tokyo, 104-0045, Japan
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National Cancer Center Hospital East
Chiba, 277-8577, Japan
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National Hospital Organization Kyushu Cancer Center
Fukuoka, 811-1395, Japan
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National Taiwan University Hospital
Taipei, 10002, Taiwan
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New York University Cancer Cen
New York, New York, 10016, United States
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Northwest Cancer Specialists - Portland (SW Barnes Rd)
Portland, Oregon, 97225, United States
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Nottingham University Hospitals NHS Trust - City Hospital
Nottingham, NG5 1PB, United Kingdom
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Ochsner Medical Center
New Orleans, Louisiana, 70121, United States
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Oncology Associates of Oregon, P.C
Eugene, Oregon, 97401, United States
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Oncology Associates of Southwest Virginia, Inc.
Blacksburg, Virginia, 24060, United States
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Oncology Hematology Care
Cincinnati, Ohio, 45242, United States
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Oregon Health & Science University
Portland, Oregon, 97239, United States
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Osaka Metropolitan University Hospital
Osaka, 545-8586, Japan
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Oxford University Hospitals NHS Foundation Trust
Oxford, OX3 7LE, United Kingdom
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Paracelsus Medizinischen Privatuniversitaet-Salzburger Landeskliniken (SALK)
Salzburg, 5020, Austria
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Pratia Ma?opolskie Centrum Medyczne (MCM) Kraków
Krakow, 30-727, Poland
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Prince of Wales Hospital
Randwick, New South Wales, 2031, Australia
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Princess Alexandra Hospital Woolloongabba
Woolloongabba, Queensland, 4102, Australia
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Prisma Health ? Upstate
Greenville, South Carolina, 29615, United States
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Pusan National University Hospital
Busan, 49241, South Korea
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Pusan National University Yangsan Hospital
Yangsan, 50612, South Korea
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Pôle de Cancérologie ? CHU de Saint?Etienne'
Saint-Priest-en-Jarez, 42270, France
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Rocky Mountain Cancer Centers, LLP
Aurora, Colorado, 80012, United States
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Ronald Reagan UCLA Medical Center
Los Angeles, California, 90024-6997, United States
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, 200025, China
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SPZOZ Ministerstwa Spraw Wewn?trznych i Administracji w Poznaniu
Późna, 60-631, Poland
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Samodzielny Publiczny Zak?ad Opieki Zdrowotnej Zespó? Szpitali Miejskich w Chorzowie
Chorzów, 41-500, Poland
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Samsung Medical Center
Seoul, 06351, South Korea
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Seattle Cancer Care Alliance
Seattle, Washington, 98109, United States
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Seoul National University Hospital
Seoul, 03080, South Korea
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Severance Hospital
Seoul, 03722, South Korea
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Shanghai East Hospital, Tongji University
Shanghai, 200120, China
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Southern Cancer Center
Daphne, Alabama, 36526, United States
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St George Hospital
Kogarah, New South Wales, 2217, Australia
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Städtisches Klinikum Dessau
Dessau, 06847, Germany
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Sunnybrook Health Sciences Centre
Toronto, Ontario, M4N 3M5, Canada
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Taipei Veterans General Hospital
Taipei, 11211, Taiwan
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Tennessee Oncology
Nashville, Tennessee, 37203-1625, United States
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Texas Oncology San Antonio Medical Center
San Antonio, Texas, 78229, United States
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Texas Oncology-Austin Midtown
Austin, Texas, 78705, United States
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Texas Oncology-Tyler
Tyler, Texas, 75702, United States
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The Cancer Institute Hospital of JFCR
Tokyo, 135-8550, Japan
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The Christie NHS Foundation Trust
Manchester, M20 4BX, United Kingdom
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The First Affiliated Hospital of College of Medicine, Zhejiang University
Hangzhou, 310003, China
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The First Hospital of Jilin University
Changchun, 130021, China
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The Johns Hopkins Hospital
Baltimore, Maryland, 21205, United States
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The Ohio State University Comprehensive Cancer Center
Cleveland, Ohio, 44106, United States
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The Ottawa Hospital
Ottawa, Ontario, K1H 8L6, Canada
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The University of Adelaide - The Queen Elizabeth Hospital (TQEH)
Woodville South, South Australia, 5011, Australia
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The University of Osaka Hospital
Osaka, 565-0871, Japan
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Tohoku University Hospital
Miyagi, 980-8574, Japan
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Tokai University Hospital
Isehara-shi, 259-1193, Japan
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UZ Gent
Ghent, 9000, Belgium
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Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, 430022, China
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Universita degli Studi di Roma ''La Sapienza" - Clinica Ematologica
Rome, Abruzzo, DUMMY_VALUE, Italy
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Universitaetsklinikum Heidelberg
Heidelberg, 69120, Germany
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Universitatsklinikum Munster
Münster, 48149, Germany
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University Hospital Kyoto Prefectural University of Medicine
Kyoto, 602-8566, Japan
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University Hospitals Case Medical Center
Cleveland, Ohio, 44106, United States
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University Hospitals of Leicester NHS Trust - Leicester Royal Infirmary
Leicester, LE1 5WW, United Kingdom
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University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
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University of Maryland
Baltimore, Maryland, 21201, United States
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University of Michigan Health System
Ann Arbor, Michigan, 48109, United States
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University of North Carolina School of Medicine
Chapel Hill, North Carolina, 27514-4221, United States
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University of Pittsburgh Cancer Institute
Pittsburgh, Pennsylvania, 15232-1309, United States
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University of Rochester Medical Center
Rochester, New York, 14642, United States
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University of Utah
Salt Lake City, Utah, 84112, United States
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Universitätsklinikum Essen
Essen, 45147, Germany
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Universitätsklinikum Halle (Saale)
Halle, 6097, Germany
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Universitätsspital Basel
Basel, 4031, Switzerland
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Uniwersytet Medyczny w Lodzi
Lodz, 93-510, Poland
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Virginia Cancer Specialists, PC
Fairfax, Virginia, 22031-4618, United States
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Vivantes Klinikum Am Urban
Berlin, 10967, Germany
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Všeobecná fakultní nemocnice v Praze
Prague, 128 08, Czechia
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Washington University
St Louis, Missouri, 63110, United States
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West Virginia Uni Med. Center - Robert Byrd Health Science
Morgantown, West Virginia, 26505, United States
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Westmead Hospital
Westmead, New South Wales, 2145, Australia
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Wiener Gesundheitsverbund ? Klinik Ottakring
Vienna, 1160, Austria
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Wojskowy Instytut Medyczny Centralny Szpital Kliniczny MON
Warsaw, 04-359, Poland
Conditions
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