New drug combo aims to improve PNH treatment
NCT ID NCT05133531
First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 28 times
Summary
This study tests a combination of two experimental drugs, pozelimab and cemdisiran, in people with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder. The goal is to see if this new combo works better and is safer than current standard treatments (ravulizumab and eculizumab). About 202 participants who have not recently received complement inhibitor therapy will be enrolled. The study measures how well the drugs control red blood cell breakdown and reduce the need for blood transfusions.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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A Beneficencia Portuguesa de Sao Paulo, BP Mirante
São Paulo, 01321-001, Brazil
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Ajou University Medical Center
Suwon, Gyeonggi-do, 16499, South Korea
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Amrita Institute of Medical Sciences (AIMS) and Research Centre Aims
Kochi, Kerala, 682041, India
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Aou Careggi
Florence, Firenze, 50139, Italy
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Bhagwan Mahaveer Cancer Hospital and Research Centre (BMCHRC)
Jaipur, 302017, India
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Casa de Saude Santa Marcelina
São Paulo, 08270-070, Brazil
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Centro de Estudos e Pesquisas em Hematologia e Oncologia
Santo André, São Paulo, 09060-650, Brazil
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Chaing Mai University
Chiang Mai, 50200, Thailand
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Chang Gung Memorial Hospital - Linkou Branch
Taoyuan, Hunan Province, 33305, Taiwan
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Changhua Christian Hospital
Changhua, 500-06, Taiwan
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China Medical University Hospital
Taichung, Central Taiwan, 40447, Taiwan
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Clinica San Felipe
Lima, 15072, Peru
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Clinical Research Center, Faculty of Medicine, Prince of Songkla University
Hat Yai, Changwat Songkhla, 90110, Thailand
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Ege University
Izmir, 35100, Turkey (Türkiye)
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Ewha Womans University Mokdong Hospital
Seoul, 07985, South Korea
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Faculty of Medicine Khon Kaen University
Khon Kaen, 40002, Thailand
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Fondazione Policlinico Universitario A. Gemelli - IRCCS
Rome, Roma, 00168, Italy
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Gachon University Gil Medical Center
Incheon, Namdong-Gu, 21565, South Korea
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George Papanikolaou Hospital
Thessaloniki, 57010, Greece
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Hematology Citta della Salute e della Scienza di Torino
Turin, 10126, Italy
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Hospital Ampang
Ampang, Selangor, 68000, Malaysia
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Hospital Clinic de Barcelona
Barcelona, 08036, Spain
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Hospital Clinico Universitario de Salamanca
Salamanca, 37007, Spain
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Hospital General JM Morales Meseguer
Murcia, 30008, Spain
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Hospital Pablo Tobon Uribe
Medellín, Antioquia, 050034, Colombia
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Hospital Queen Elizabeth
Kota Kinabalu, Sabah, 88586, Malaysia
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Hospital Tg Ampuan Afzan
Kuantan, Pahang, 25200, Malaysia
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Hospital Universitario Basurto
Bilbao, Vizcaya, 48013, Spain
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Hualien Tzu Chi Hospital
Hualien City, 97002, Taiwan
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Institute of Hematology and Transfusion Medicine
Warsaw, 02-776, Poland
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Ion Chiricuta Oncology Institute
Cluj-Napoca, Cluj, 400015, Romania
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Istanbul University
Istanbul, 34418, Turkey (Türkiye)
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Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital
Nagoya, Aichi-ken, 466-8650, Japan
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Jordan University Hospital (JUH)
Amman, 11942, Jordan
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K J Somaiya Super Specialty Hospital & Research Centre
Mumbai, Maharashtra, 400022, India
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Kaohsiung Medical University Hospital
Kaohsiung City, 80756, Taiwan
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King Chulalongkorn Memorial Hospital
Bangkok, 10330, Thailand
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King George Hospital
Lucknow, Uttar Pradesh, 226003, India
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Korea University Hospital
Seoul, 02841, South Korea
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Malabar Cancer Center, Kerala
Kannur, Kerala, 670103, India
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Matsushita Memorial Hospital
Moriguchi, Osaka, 570-8540, Japan
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Municipal Hospital Filantropia
Craiova, Dolj, 200143, Romania
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NTT Medical Center Tokyo
Shinagawa-ku, Tokyo, 141-8625, Japan
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National Cheng Kung University Hospital
Tainan, 704, Taiwan
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National Taiwan University Hospital
Taipei, 100229, Taiwan
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National University Hospital
Singapore, 119074, Singapore
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Ogaki Municipal Hospital
Ōgaki, Gifu, 503-8502, Japan
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Peking Union Medical College Hospital
Beijing, Beijing Municipality, 100032, China
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Postgraduate Institute of Medical Education & Research (PGIMER)
Chandigarh, Punjab, 708248, India
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Pusan National University Hospital
Busan, 49241, South Korea
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Rajiv Gandhi Cancer Institute & Research Center (RGCIRC) - Rohini Campus
New Delhi, National Capital Territory of Delhi, 110085, India
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Samsung Medical Center
Seoul, 06351, South Korea
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Sanjay Gandhi Postgraduate Institute of Medical Sciences
Lucknow, Uttar Pradesh, 226014, India
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Semmelweis University
Budapest, 1083, Hungary
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Seoul St. Mary's Hospital - The Catholic University of Korea
Seoul, 065791, South Korea
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Servicio de Hematologia del Hospital Universitario de la Uanl
Monterrey, Nuevo León, 64460, Mexico
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Severance Hospital
Seoul, 03722, South Korea
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St James Hospital
Leeds, LS9 7TF, United Kingdom
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St Lukes Medical Center
Quezon, Central Luzon, 1011, Philippines
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St. Vincent Hospital
Suwon, Gyeonggi-do, 16247, South Korea
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Szpital Uniwersytecki Nr2 Bydgoszcz
Bydgoszcz, 85-168, Poland
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Taichung Veterans General Hospital (VGHTC)
Taichung, 4070, Taiwan
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Targu Mures Clinical County Emergency Hospital
Târgu Mureş, Mureș County, 540136, Romania
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The Oncology Institute of Hope & Innovation
Whittier, California, 90602, United States
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Toronto General Hospital
Toronto, Ontario, M5G 2C4, Canada
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Tri-Service General Hospital
Taipei, 114, Taiwan
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University Clinical Center Medical University of Gdansk
Gdansk, Pomeranian Voivodeship, 80-214, Poland
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University of Tsukuba Hospital
Tsukuba, Ibaraki, 305-8576, Japan
Conditions
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