New antibiotic cocktail shows promise against tough lung infections

NCT ID NCT05204563

Completed Disease control Sponsor: Evopoint Biosciences Inc. Source: ClinicalTrials.gov ↗

First seen Nov 06, 2025 · Last updated May 24, 2026 · Updated 28 times

Summary

This study tested a new antibiotic combination (IMI-XNW4107) against an existing one (IMI/REL) in 450 adults with pneumonia caught in the hospital or from a ventilator. The main goal was to see if the new drug was at least as good at preventing death by day 14. The trial is complete, and results will show if the new option works as well or better.

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Contacts and locations

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Locations

APHP

Paris, Paris, 75018, France
Bellvitge University Hospital

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Bnei-Zion Medical Center

Haifa, Haifa District, 3339419, Israel
CH victor dupouy

Argenteuil, 95100, France
CHU de Nice

Nice, Alpes Maritimes, 06200, France
Carolinas Medical Center

Charlotte, North Carolina, 28204, United States
Chu Nimes

Nîmes, GARD, 30029, France
Chu Reims- Medical Icu

Reims, Grand Est, 51100, France
Cochin

Paris, Paris, 75014, France
Cox Health

Springfield, Missouri, 65807, United States
Denver Health and Hospital Authority

Denver, Colorado, 80204, United States
Galilee Medical Center / Department int med A

Nahariya, Western Galilee, 2210001, Israel
Groupe Hospitalier Paris Saint-Joseph

Paris, Paris, 75014, France
Hartford Hospital

Hartford, Connecticut, 37920, United States
Hillel Yaffe Medical Center

Hadera, Israel, 38100, Israel
Hospital Clínic of Barcelona

Barcelona, Barcelona, 08036, Spain
Hospital Universitari Vall Hebron

Barcelona, Barcelona, 08035, Spain
Hospital Universitario de Tarragona Joan XXIII

Tarragona, Tarragona, 43007, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, Barcelona, 08041, Spain
Hospital del Mar

Barcelona, Barcelona, 08003, Spain
Hôpital Foch

Suresnes, Île-de-France Region, 92150, France
Hôpitaux Universitaires de Strasbourg

Strasbourg, Alsace, 67000, France
Jackson Memorial Hospital (JMH) - Ryder Trauma Center

Miami, Florida, 33136, United States
Nouvel Hopital CIVIL/ Medecine Intensive Reanimation

Strasbourg, Bas-Rhin, 67091, France
Rambam Critical Care division

Haifa, Israel, 3525408, Israel
Shamir Medical Center

Be’er Ya‘aqov, HaMercaz, 70300, Israel
Sheba Medical Center

Ramat Gan, Center, 5262100, Israel
Tel Aviv Medical Center

Tel Aviv, Israel, 64239, Israel
The University of Tennessee Medical Center

Knoxville, Tennessee, 37920, United States
USF-TGH

Tampa, Florida, 33606, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of Maryland Medical Center

Baltimore, Maryland, 21201, United States
VA medical center

Buffalo, New York, 14215, United States
Wolfson Medical Center

H̱olon, Central District, 58100, Israel
intensive Unit Care CHU Amiens Picardie

Amiens, Picardie, 80054, France

Conditions

Explore the condition pages connected to this study.

HOSPITAL ACQUIRED BACTERIAL PNEUMONIA OR VENTILATOR-ASSOCIATED BACTERIAL PNEUMONIA