Mind over muscle: could a fake pill enhance Real-World athletic performance?
NCT ID NCT07742150
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This study explores whether believing you've taken caffeine can improve physical performance in real-world sports settings. Healthy, physically active adults will be randomly assigned to receive caffeine, a placebo (starch capsule), or no treatment, then perform sport-specific exercise tests. Researchers will measure performance and heart rate to separate the drug's actual effects from those driven by expectation. The goal is to understand how the placebo effect works outside the lab and whether it can be harnessed to boost athletic and cognitive performance.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Caffeine (6mg/kg) and placebo (starch capsule) and sham (no treatment)
- What this could lead to
- If the placebo effect is strong, it could lead to non-drug strategies to enhance athletic performance and cognitive function in real-world settings.
- What could go wrong
- The trial is early-stage and results may not apply broadly. The placebo effect may be small or inconsistent across different sports and individuals.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Mar 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 35 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age between 20 and 35 years, * Healthy adults, * Regular physical activity, * Normal or corrected-to-normal vision, * Habitual caffeine consumption. Exclusion Criteria: * History of neurological, psychiatric, cardiovascular, or metabolic disorders, * Current use of medication or supplements affecting the central nervous system, * Musculoskeletal injuries that would impair physical performance, * No habitual caffeine consumption or severe negative side effects of caffeine, * Diagnosed sleep disorders or chronic fatigue, * Diagnosed major depressive disorder or other severe psychiatric conditions, * Presence of any menstrual disorders, * Inability to attend all experimental study visits.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Poznan University of Physical Education
Poznan, Greater Poland Voivodeship, Poland
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