New model aims to perfect antibiotic dosing for sepsis in the ICU

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Major patient (age ≥18 years) male or female. * Patient hospitalized in intensive care for sepsis, involving (i) a suspected or proven infection; (ii) a systemic inflammatory response; (iii) dysfunction of at least one organ, according to the international consensus "sepsis-3". * Patient with an arterial catheter that can be used for blood sampling by the time the first dose of piperacillin / tazobactam is administered. * Patient for whom treatment with piperacillin / tazobactam, alone or in combination with another antibiotic, is prescribed according to the following modalities (drug SPC): scheduled antibiotic treatment for at least 48 hours in IV infusion of 4 g of piperacillin and 0.5 g tazobactam over 3 hours, every 6 hours or every 8 hours. * Patient affiliated to a social security scheme. * Patient informed and given his non-opposition. If the patient is unable to do so (emergency situations) the non-opposition will be obtained from the patient's representative. Exclusion Criteria: * Treatment with piperacillin and / or tazobactam within 7 days prior to evaluation. * Patient with a history of allergy to penicillins or β-lactams. * Kidney function of Kdigo score = 3 (3 times baseline plasma creatinine or plasma creatinine ≥ 354μmol / L or extra-renal clearance, or diuresis \<0.3ml / kg / h for ≥ 24h or anuria for ≥ 12h) to not include patients at very high risk of extra-renal clearance within 48 hours. * Hypersensitivity to the active substances, to any other antibacterial agent of the penicillin class or to any of the excipients. * History of severe allergic reaction to any other β-lactam. * Patient being treated with extrarenal treatment. * Patient being treated with extracorporeal circulation (ECMO). * Hepatic insufficiency patient with Child C. cirrhosis. * Patient who refused to participate or refused participation by the representative. * Person deprived of liberty by an administrative or judicial decision. * Person under tutorship or curatorship. * Pregnant or nursing woman.