Could a common seizure drug calm ICU delirium?
NCT ID NCT07548489
First seen Apr 24, 2026 · Last updated Jun 19, 2026 · Updated 12 times
Summary
This study tests whether phenobarbital, a drug used for seizures, can safely treat agitated delirium in ICU patients. Agitated delirium causes confusion and dangerous impulsiveness. Researchers will compare phenobarbital to standard antipsychotic medications in 150 adults, measuring how long patients stay in the ICU and hospital, and how much extra calming medicine they need.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Duke Regional Hospital
Durham, North Carolina, 27704, United States
Contact Phone: •••-•••-••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Phenobarbital
What this could lead to
If it works, this could offer a new, possibly safer option to calm agitated ICU patients and shorten their hospital stay.
What could go wrong
This is a Phase 3 trial, but it's still early to know if phenobarbital is truly better or safer than current treatments. Side effects like sedation or breathing problems are possible.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.