New shots aim to soothe severe eczema in major pfizer trial

NCT ID NCT05995964

Symptom relief Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests two experimental injectable drugs (PF-07275315 and PF-07264660) for adults with moderate to severe atopic dermatitis (eczema) that hasn't improved with skin creams. About 340 participants will receive the drugs or a placebo over up to 13 months to see if the medicines safely reduce itching and rash. The goal is to achieve at least a 75% improvement in eczema severity.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 340 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2023

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Must meet the following AD criteria: 1. Participants aged 18 years or older 2. Clinical diagnosis of chronic atopic dermatitis: 1. for at least 6 months prior to Day 1 with diagnosis confirmed by photograph; 2. Either an inadequate response to treatment with standard of care treatments (excluding systemic immunosuppressant treatments) for at least 4 consecutive weeks within 6 to 12 months of the first dose of the study intervention; OR documented reason why topical treatments are considered medically inappropriate; 3. Moderate to severe AD defined as having an affected BSA ≥10%, vIGA ≥3, and EASI ≥16 at both the screening and baseline visits). 4. Bio-experienced cohort-partial or non-responder to anti-inflammatory proteins (also known as biologics), intolerance or AEs to anti-inflammatory proteins or loss of access to anti-inflammatory proteins with ≥12 weeks of treatment within 5 years. Other Inclusion Criteria: 3. BMI of 17.5 to 40 kg/m2; and a total body weight \>45 kg (100 lbs). 4. Willing and able to comply with all scheduled visits, treatment plan, laboratory tests and other study procedures. Exclusion Criteria: \- Medical Conditions: 1. Significant allergic or autoimmune diseases, other than AD and well controlled mild to moderate including but not limited to: SLE or other complement disorders; Type 1 diabetes; IBD; Multiple Sclerosis. 2. History of significant allergic reactions, including anaphylaxis and reactions to protein therapeutics, including hypersensitivity to PF-07275315 or PF-07264660 or to the excipients of the formulated drug products. Participants with significant reactions to single, identified, avoidable allergens (eg, peanut allergy) may be eligible if avoidance of these allergens during the study is feasible. 3. Any of the following acute or chronic infections or infection history: 1. Active infection (including helminth or parasitic) requiring treatment within 2 weeks prior to screening; 2. Infection requiring hospitalization or systemic (parenteral) antimicrobial therapy within 60 days prior to Day 1; 3. Active chronic or acute skin infection requiring treatment with systemic \[(not IV)\] antibiotics, antivirals, antiparasitics, antiprotozoals, or antifungals within 2 weeks prior to Day 1, or superficial skin infections (requiring no more than topical anti-infective treatments) within 1 week prior to Day 1. 4. Any infection judged to be an opportunistic infection or clinically significant by the investigator, within 6 months prior to Day 1; 4. History of or current evidence of inflammatory skin conditions (eg, psoriasis, seborrheic dermatitis, lupus) at the time of Day 1 that could interfere with evaluation of AD or response to treatment. 5. Any medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study. \- Prior/Concomitant Therapy: 6. Current use of any prohibited concomitant medication(s). 7. Phototherapy narrowband UVB (NB UVB) or broadband phototherapy or regular use (more than 2 visits per week) of a tanning booth/parlor within 4 weeks prior to Day 1. \- Prior/Concurrent Clinical Study Experience: 8. Previous administration with an investigational product (drug or vaccine) within 30 days (or as determined by the local requirement) or 5 half lives preceding the first dose of study intervention used in this study (whichever is longer). 9. HIV infection, or infection with hepatitis B or hepatitis C viruses according to protocol-specific testing algorithm. 10. Evidence of active or latent TB, or inadequately treated infection with Mycobacterium TB. A participant who is currently being treated for active or latent TB infection must be excluded from this study.

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Conditions

The condition(s) this trial relates to.

atopic eczema Eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atopic dermatitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

88 sites in 7 countries. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

AboutSkin Research, LLC
TERMINATED

Greenwood Village, Colorado, 80111, United States
Affiliated Hospital of Jiangsu University
NOT_YET_RECRUITING

Zhenjiang, Jiangsu, 212001, China
Allervie Clinical Research
RECRUITING

Birmingham, Alabama, 35209, United States
Alpesh D. Desai, DO PLLC
ACTIVE_NOT_RECRUITING

Houston, Texas, 77008, United States
Apex Clinical Research Center
RECRUITING

Mayfield Heights, Ohio, 44124, United States
Australian Clinical Research Network
RECRUITING

Sydney, New South Wales, NSW 2035, Australia
BAG Drs. Med. Quist PartG
RECRUITING

Mainz, Rhineland-Palatinate, 55128, Germany
Banner - University Medicine Dermatology Clinic
RECRUITING

Tucson, Arizona, 85718, United States
Beijing Friendship Hospital Affiliate of Capital University
RECRUITING

Beijing, Beijing Municipality, 100050, China
Box Hill Hospital
RECRUITING

Box Hill, Victoria, 3128, Australia
California Allergy and Asthma Medical Group
RECRUITING

Los Angeles, California, 90025, United States
Centre de Recherche Saint-Louis inc.
RECRUITING

Québec, G1W 4R4, Canada
Centrum Medyczne Angelius Provita
RECRUITING

Katowice, Silesian Voivodeship, 40-611, Poland
Chengdu second people's hospital
RECRUITING

Chengdu, Sichuan, 610017, China
Clinical Neuroscience Solutions Inc.
RECRUITING

Memphis, Tennessee, 38119, United States
Clinical Neuroscience Solutions, Inc.
RECRUITING

Orlando, Florida, 32801, United States
Clinical Partners, LLC
RECRUITING

Johnston, Rhode Island, 02919, United States
Complete Dermatology
RECRUITING

Sugar Land, Texas, 77479, United States
DCT-Stone Oak, LLC dba Discovery Clinical Trials
RECRUITING

San Antonio, Texas, 78258, United States
Dawes Fretzin Clinical Research Group, LLC
RECRUITING

Indianapolis, Indiana, 46250, United States
DermEdge Research
RECRUITING

Mississauga, Ontario, L4Y 4C5, Canada
Dermatology Cosmetic Laser Medical Associates of La Jolla, Inc.
RECRUITING

San Diego, California, 92121, United States
Dermatology Hospital of Jiangxi Province
RECRUITING

Nanchang, Jiangxi, 330000, China
Dermatology Treatment and Research Center
RECRUITING

Dallas, Texas, 75230, United States
Dermedic Jacek Zdybski
RECRUITING

Ostrowiec Świętokrzyski, Świętokrzyskie Voivodeship, 27-400, Poland
Dongguan People's Hospital
NOT_YET_RECRUITING

Dongguan, Guangdong, 523109, China
Empire Dermatology
RECRUITING

East Syracuse, New York, 13057, United States
Epic Medical Research - Oklahoma
RECRUITING

Chickasha, Oklahoma, 73018, United States
Fachklinik Bad Bentheim
RECRUITING

Bad Bentheim, Lower Saxony, 48455, Germany
First Affiliated Hospital of Kunming Medical University
RECRUITING

Kunming, Yunnan, 650032, China
Florida International Medical Research
TERMINATED

Coral Gables, Florida, 33134, United States
Floridian Research Institute Llc
RECRUITING

Miami, Florida, 33179, United States
ForCare Clinical Research
RECRUITING

Tampa, Florida, 33613, United States
Fremantle Dermatology
RECRUITING

Fremantle, Western Australia, 6160, Australia
Fukuwa Clinic
RECRUITING

Chuo-ku, Tokyo, 104-0031, Japan
GCP Research, Global Clinical professionals
RECRUITING

St. Petersburg, Florida, 33705, United States
Global Health Research Center, Inc.
RECRUITING

Miami Lakes, Florida, 33016, United States
Guangdong Province Dermatology Hospital
RECRUITING

Guangzhou, Guangdong, 510091, China
Hangzhou Third Hospital
RECRUITING

Hangzhou, Zhejiang, 310009, China
Huashan Hospital, Fudan University
RECRUITING

Shanghai, Shanghai Municipality, 200040, China
INTERMED Groupe Sante
RECRUITING

Chicoutimi, Quebec, G7H 7Y8, Canada
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Lima's Excellence in Allergy and Dermatology Research
RECRUITING

Hamilton, Ontario, L8L 3C3, Canada
MI Skin Innovations
RECRUITING

Northville, Michigan, 48167, United States
Magdeburger Company for Medical Studies and Services
RECRUITING

Magdeburg, Saxony-Anhalt, 39104, Germany
Marvel Clinical Research
RECRUITING

Huntington Beach, California, 92647, United States
Maryland Laser Skin and Vein
RECRUITING

Hunt Valley, Maryland, 21030, United States
Medical Corporation Heishinkai OPHAC Hospital
ACTIVE_NOT_RECRUITING

Osaka, Osaka, 532-0003, Japan
Medical Dermatology Specialists
RECRUITING

Phoenix, Arizona, 85006, United States
Medicor Research Inc
RECRUITING

Greater Sudbury, Ontario, P3C 1X3, Canada
Michigan Center for Research Company
RECRUITING

Clarkston, Michigan, 48346, United States
Naoko Dermatology Clinic
RECRUITING

Setagaya-ku, Tokyo, 158-0097, Japan
National Allergy and Asthma
RECRUITING

North Charleston, South Carolina, 29420, United States
Niepubliczny Zakład Opieki Zdrowotnej Zespół Poradni Specjalistycznych "Termedica"
RECRUITING

Poznan, Greater Poland Voivodeship, 60-681, Poland
Nihonbashi Sakura Clinic
RECRUITING

Chuo-ku, Tokyo, 103-0025, Japan
Nomura Dermatology Clinic
RECRUITING

Yokohama, Kanagawa, 221-0825, Japan
North Texas Center for Clinical Research
RECRUITING

Frisco, Texas, 75034, United States
Northridge Clinical Trials
RECRUITING

Northridge, California, 91325, United States
Onyx Clinical Research
RECRUITING

Phoenix, Arizona, 85050, United States
Onyx Clinical Research - Peoria
RECRUITING

Peoria, Arizona, 85381, United States
Osaka Metropolitan University Hospital
RECRUITING

Osaka, Osaka, 545-8586, Japan
Paddington Testing Co, Inc
RECRUITING

Philadelphia, Pennsylvania, 19103, United States
Pratia MCM Krakow
RECRUITING

Krakow, Lesser Poland Voivodeship, 30-727, Poland
Private Practice - Dr. Bobby Buka
RECRUITING

New York, New York, 10012, United States
Profound Research LLC
RECRUITING

Oceanside, California, 92056, United States
Renaissance Research and Medical Group
ACTIVE_NOT_RECRUITING

Cape Coral, Florida, 33991, United States
Revival Research
RECRUITING

Doral, Florida, 33122, United States
Revival Research Institute LLC
RECRUITING

Troy, Michigan, 48084, United States
Sadick Research Group
RECRUITING

New York, New York, 10075, United States
Shanghai First People's Hospital
RECRUITING

Shanghai, 201620, China
Sinclair Dermatology
RECRUITING

East Melbourne, Victoria, 3002, Australia
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310016, China
Skin Specialists, PC dba Schlessinger MD
RECRUITING

Omaha, Nebraska, 68144, United States
SouthCoast Research Center
TERMINATED

Miami, Florida, 33136, United States
Southern Indiana Clinical Trials
RECRUITING

New Albany, Indiana, 47150, United States
Spartanburg Medical Research
RECRUITING

Spartanburg, South Carolina, 29303, United States
St. Jude Clinical Research
TERMINATED

Doral, Florida, 33172, United States
Sudbury Skin Clinique
RECRUITING

Greater Sudbury, Ontario, P3C 1X8, Canada
Sunwise Clinical Research
TERMINATED

Walnut Creek, California, 94596, United States
Synexus Polska Sp. z o.o. Oddzial w Katowicach
RECRUITING

Katowice, 40-040, Poland
Synexus Polska Sp. z o.o. Oddzial we Wroclawiu
RECRUITING

Wroclaw, Lower Silesian Voivodeship, 50-381, Poland
The First Affiliated Hospital Of Fujian Medical University
RECRUITING

Fuzhou, Fujian, 350005, China
The First Affiliated Hospital of Xi'an Jiaotong University
RECRUITING

Xi'an, Shaanxi, 710061, China
The First Hospital of Hebei Medical University
RECRUITING

Shijiazhuang, Hebei, 050031, China
The Second Xiangya Hospital of Central South University
RECRUITING

Changsha, Hu'nan, 410011, China
The first hospital of jilin university
RECRUITING

Changchun, Jilin, 130021, China
Tianjin Medical University General Hospital
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, 300052, China
Toronto Research Centre
RECRUITING

Toronto, Ontario, M3H 5Y8, Canada
Union Hospital Tongji Medical College Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, 430000, China
Unity Clinical Research
RECRUITING

Oklahoma City, Oklahoma, 73118, United States
University Dermatology Trials, INC.
RECRUITING

Newport Beach, California, 92660, United States
Velocity Clinical Research, Medford
ACTIVE_NOT_RECRUITING

Medford, Oregon, 97504, United States
Virginia Dermatology and Skin Cancer Center
TERMINATED

Norfolk, Virginia, 23502, United States
Vital Prospects Clinical Research Institute, PC
RECRUITING

Tulsa, Oklahoma, 74136, United States
West Dermatology La Jolla
RECRUITING

San Diego, California, 92121, United States
Wiseman Dermatology Research Inc.
RECRUITING

Winnipeg, Manitoba, R3M 3Z4, Canada
Zhejiang Provincial People's Hospital
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310014, China
Ziaderm Research LLC
RECRUITING

North Miami Beach, Florida, 33162, United States

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