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New asthma drug shows promise in Mid-Stage trial

NCT ID NCT06977581

Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new medicine called PF-07275315 for adults with moderate-to-severe asthma that is not well controlled. Participants will receive either the drug or a placebo as injections over 12 weeks. The goal is to see if the drug improves lung function and is safe. About 252 people aged 18 to 70 will take part for around 7.5 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
PF-07275315
What this could lead to
If it works, this could lead to a new treatment option for people with moderate-to-severe asthma that is not well controlled by current medications.
What could go wrong
This is an early phase 2 trial with only 252 participants, so results may not apply to everyone. The drug is compared to a placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 252 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Must meet the following asthma criteria: 1. History of persistent, moderate-to-severe asthma for at least 12 months prior to screening. 2. Must have experienced at least 1 asthma exacerbation requiring treatment with systemic steroids (oral or parenteral) for 3 days or more within 12 months of the screening visit. 3. At least 2 of the 3 pre-bronchodilator FEV1 values collected in the run-in period and the mean of the of pre-bronchodilator FEV1 values collected in the run-in period are ≥30% to \<80% of predicted normal values. 4. Positive bronchodilator responsiveness as evidenced by increase in FEV1 of at least 12% and 200 mL for spirometry conducted during screening period. 5. Maintenance (controller) treatment that minimally includes a medium to high dose ICS - LABA combination consistent with GINA Step 4/5 (either Track 1 or Track 2) for 12 months prior to the screening visit and at a stable dose for at least 3 months prior to the screening visit. 6. ACQ-5 score of ≥1.5 at screening visit and prior to randomization. Other Inclusion Criteria: 7. Body mass index between 18 40 kg/m2 at screening. Exclusion Criteria: Medical Conditions: 1. Any medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study. 2. Evidence of lung disease(s) other than asthma, either clinical evidence, spirometry, or imaging (Chest X-ray, CT, MRI) within 12 months of the screening visit, as per local standard of care, including but not limited to: Chronic obstructive pulmonary disease, Other emphysematous lung disease such as alpha-1 antitrypsin disease, Cystic fibrosis, Emphysema, Idiopathic pulmonary fibrosis, Churg-Strauss syndrome, Allergic bronchopulmonary aspergillosis, Sarcoidosis 3. Diagnosed with any of the following acute or chronic infections or infection history: * Active helminth or parasitic infection requiring treatment within 2 weeks prior to screening; * Infection requiring hospitalization or systemic (parenteral) antimicrobial therapy within 60 days prior to Day 1; * Any infection judged to be an opportunistic infection or clinically significant by the investigator, within 6 months prior to Day 1. Prior/Concomitant Therapy: 4. Prior or current use of any prohibited concomitant medication(s) or unwillingness or inability to use a required concomitant medication(s). 5. Prior or concurrent treatment with either approved or experimental biologic treatment (such as inhibitors of IL-4, IL-13, IL-33/ST2, IL-4Rα, TSLP, IL-5, OX40/OX40L or IgE) or targeted synthetic drugs (such as JAK inhibitors) for the treatment of asthma or other type 2 inflammatory diseases, including but not limited to: AD, EoE, CRS. 6. Treatment with any dose level of systemic (oral, injectable, or intraarticular) corticosteroids within 28 days of the screening visit. 7. Prior (within 12 weeks prior to screening) or planned concomitant treatment with immunoglobulin supplementation (eg, IV Ig or SC Ig). 8. History of anaphylaxis to antibody therapeutic or to PF-07275315 or to the excipients of the formulated drug products. 9. Bronchial thermoplasty within the previous 24 months. Prior/Concurrent Clinical Study Experience: 10. Administration of an investigational drug product within 30 days or 5 half lives preceding the screening visit (whichever is longer). Participation in studies of other investigational products (drug or vaccine) at any time during participation in this study.

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Conditions

The condition(s) this trial relates to.

Airway Obstruction asthma Dyspnea lung disorder Respiratory Hypersensitivity Respiratory Sounds respiratory system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asthma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    131 sites in 15 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • ALERGO-MED OŚRODEK BADAŃ KLINICZNYCH Sp. z o.o.

    RECRUITING

    Tarnów, Lesser Poland Voivodeship, 33-100, Poland

  • AZ Sint-Maarten

    RECRUITING

    Mechelen, Antwerpen, 2800, Belgium

  • Addenbrooke's Hospital

    RECRUITING

    Cambridge, Cambridgeshire, CB2 2QQ, United Kingdom

  • Alergologia Plus sp. z o.o.

    RECRUITING

    Poznan, Greater Poland Voivodeship, 60-693, Poland

  • Alina Clinical Trials, LLC.

    RECRUITING

    Dallas, Texas, 75209, United States

  • Allergy & Asthma Clinical Research

    RECRUITING

    Walnut Creek, California, 94598, United States

  • Allergy and Asthma Associates of Santa Clara Valley Research Center

    RECRUITING

    San Jose, California, 95117, United States

  • Allergy, Asthma and Clinical Research

    NOT_YET_RECRUITING

    Oklahoma City, Oklahoma, 73120, United States

  • American Health Research

    RECRUITING

    Charlotte, North Carolina, 28277, United States

  • Antelope Valley Clinical Trials

    RECRUITING

    Lancaster, California, 93534, United States

  • Asan Medical Center

    RECRUITING

    Seoul, Seoul-teukbyeolsi [seoul], 05505, South Korea

  • Azienda Ospedaliera Ordine Mauriziano di Torino

    RECRUITING

    Torino, 10128, Italy

  • Azienda Ospedaliero Universitaria Senese

    RECRUITING

    Siena, Tuscany, 53100, Italy

  • Azienda Ospedaliero-Universitaria San Luigi Gonzaga

    RECRUITING

    Orbassano, Piedmont, 10043, Italy

  • Azienda USL Reggio Emilia - Arcispedale Santa Maria Nuova (ASMN) - IRCCS

    RECRUITING

    Reggio Emilia, Emilia-Romagna, 42123, Italy

  • Beijing Chao-Yang Hospital, Capital Medical University

    RECRUITING

    Beijing, Beijing Municipality, 100020, China

  • Bradford Royal Infirmary

    NOT_YET_RECRUITING

    Bradford, BD9 6RJ, United Kingdom

  • CEFISPIRO s.r.o.

    RECRUITING

    Lovosice, 410 02, Czechia

  • California Medical Research Associates

    RECRUITING

    Northridge, California, 91324, United States

  • Centre Hospitalier Régional de la Citadelle

    RECRUITING

    Liège, 4000, Belgium

  • Centro de Investigaciones Metabólicas (CINME)

    RECRUITING

    Buenos Aires, C1056ABI, Argentina

  • Chandler Clinical Trials

    RECRUITING

    Chandler, Arizona, 85224, United States

  • Chang Gung Medical Foundation-Linkou Branch

    RECRUITING

    Taoyuan, 333, Taiwan

  • Changhua Christian Hospital

    RECRUITING

    Changhua County, Changhua, 50006, Taiwan

  • China-Japan Friendship Hospital

    NOT_YET_RECRUITING

    Beijing, Beijing Municipality, 100029, China

  • Christie Clinic - University

    RECRUITING

    Champaign, Illinois, 61820, United States

  • Christie Clinic - Windsor

    RECRUITING

    Champaign, Illinois, 61822, United States

  • Circuit Clinical / Impact Medical Allergy, Asthma & Immunology

    RECRUITING

    Riverdale, New Jersey, 07457, United States

  • Clinical Research Associates of Central PA, LLC

    RECRUITING

    DuBois, Pennsylvania, 15801, United States

  • Clinical Research Of Gastonia

    NOT_YET_RECRUITING

    Gastonia, North Carolina, 28054, United States

  • Clinical Research Partners, LLC

    RECRUITING

    Richmond, Virginia, 23226, United States

  • Clinical Research of Rock Hill

    RECRUITING

    Rock Hill, South Carolina, 29732, United States

  • Colorado ENT & Allergy

    RECRUITING

    Colorado Springs, Colorado, 80923, United States

  • Cpcc-Research Llc

    NOT_YET_RECRUITING

    East Point, Georgia, 30344, United States

  • Da Vinci Magánklinika

    RECRUITING

    Pécs, 7635, Hungary

  • Diagnostic Consultative Center Aleksandrovska

    RECRUITING

    Sofia, Sofia (stolitsa), 1431, Bulgaria

  • Dobrostan Gabinet Lekarskie

    RECRUITING

    Wroclaw, Lower Silesian Voivodeship, 53-301, Poland

  • Durban International Clinical Research Site, Enhancing Care Foundation

    NOT_YET_RECRUITING

    Durban, KwaZulu-Natal, 4301, South Africa

  • Erzsebet Gondozohaz

    RECRUITING

    Gödöllő, Pest County, 2100, Hungary

  • Fakultni nemocnice Hradec Kralove

    RECRUITING

    Hradec Králové, 500 05, Czechia

  • Far Eastern Memorial Hospital

    RECRUITING

    New Taipei City, NEW Taipei, 220, Taiwan

  • Fujieda Municipal General Hospital

    RECRUITING

    Fujieda, Shizuoka, 426-8677, Japan

  • Fukuoka National Hospital

    RECRUITING

    Fukuoka, 811-1394, Japan

  • Fukuwa Clinic

    RECRUITING

    Chuo-ku, Tokyo, 104-0031, Japan

  • Fundacion Scherbovsky

    RECRUITING

    Mendoza, 5500, Argentina

  • Fundación Respirar

    RECRUITING

    Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ABP, Argentina

  • Greater Heights & Memorial Pulmonary and Sleep

    RECRUITING

    Houston, Texas, 77008, United States

  • Hamamatsu Rosai Hospital

    RECRUITING

    Hamamatsu, Shizuoka, 430-8525, Japan

  • Hammersmith Hospital

    NOT_YET_RECRUITING

    London, London, CITY of, W12 0HS, United Kingdom

  • Henderson Clinical Trials

    RECRUITING

    Henderson, Nevada, 89052, United States

  • Hiroshima Prefectural Hospital

    RECRUITING

    Hiroshima, 734-0004, Japan

  • Horizon Clinical Research Group

    RECRUITING

    Cypress, Texas, 77429, United States

  • Hospital Universitario 12 de Octubre

    NOT_YET_RECRUITING

    Madrid, 28041, Spain

  • Hospital Universitario La Paz

    RECRUITING

    Madrid, Madrid, Comunidad de, 28046, Spain

  • Hospital Universitario Marqués de Valdecilla

    NOT_YET_RECRUITING

    Santander, Cantabria, 39008, Spain

  • Hospital Universitario Quironsalud Madrid

    NOT_YET_RECRUITING

    Pozuelo de Alarcón, Madrid, 28223, Spain

  • Hospital Universitario Virgen de la Victoria

    NOT_YET_RECRUITING

    Málaga, Málaga, 29010, Spain

  • Houston Pulmonary Sleep and Allergy Associates

    RECRUITING

    Houston, Texas, 77065, United States

  • IRCCS Istituto Clinico Humanitas

    RECRUITING

    Rozzano, Milano, 20089, Italy

  • Inner Mongolia People's Hospital

    RECRUITING

    Hohhot, Inner Mongolia, 010017, China

  • Innovo Research - Christie Clinic

    RECRUITING

    Champaign, Illinois, 61820, United States

  • Instituto Ave Pulmo

    RECRUITING

    Mar del Plata, Buenos Aires, 7600, Argentina

  • Instituto de Salud Respiratoria

    RECRUITING

    Mendoza, 5500, Argentina

  • Investigaciones en Patologias Respiratorias

    RECRUITING

    San Miguel de Tucumán, Tucumán Province, 4000, Argentina

  • Jeonbuk National University Hospital

    RECRUITING

    Jeonju, Jeonrabugdo, 54907, South Korea

  • Jiangsu Province Hospital

    NOT_YET_RECRUITING

    Nanjing, Jiangsu, 210029, China

  • Jiangxi Provincial People's Hospital

    RECRUITING

    Nanchang, Jiangxi, 330006, China

  • KLIMED Marek Klimkiewicz

    RECRUITING

    Bychawa, Lublin Voivodeship, 23-100, Poland

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    RECRUITING

    Kaohsiung City, 807, Taiwan

  • Kobe City Medical Center West Hospital

    RECRUITING

    Kobe, Hyōgo, 653-0013, Japan

  • Koch Róbert Kórház és Rendelőintézet

    RECRUITING

    Edelény, Borsod-Abauj Zemplen county, 3780, Hungary

  • Konkuk University Medical Center

    RECRUITING

    Seoul, Seoul-teukbyeolsi [seoul], 05030, South Korea

  • Korea University Guro Hospital

    RECRUITING

    Seoul, Seoul-teukbyeolsi [seoul], 08308, South Korea

  • Layrek Clinical Research

    RECRUITING

    Tulsa, Oklahoma, 74133, United States

  • MEDITRIAL s.r.o.

    RECRUITING

    Jindrichuv Hradec III, South Bohemian Region, 377 01, Czechia

  • Mazda Hospital

    RECRUITING

    Aki-gun Fuchu-cho, Hiroshima, 735-8585, Japan

  • Małopolskie Centrum Alergologii

    RECRUITING

    Krakow, Lesser Poland Voivodeship, 31-624, Poland

  • Medical Center New Rehabilitation Center EOOD

    RECRUITING

    Stara Zagora, 6001, Bulgaria

  • Medical Center Pulmo - 2018 EOOD

    RECRUITING

    Haskovo, 6300, Bulgaria

  • Medical Center Pulmovision

    RECRUITING

    Sofia, 1756, Bulgaria

  • Metroplex Pulmonary and Sleep Center

    ACTIVE_NOT_RECRUITING

    McKinney, Texas, 75069, United States

  • Mudr.I.Cierna Peterova s.r.o.

    RECRUITING

    Brandýs nad Labem, Central Bohemia, 25001, Czechia

  • NHO Kinki Chuo Chest Medical Center

    RECRUITING

    Sakai, Osaka, 591-8555, Japan

  • Nanjing First Hospital

    RECRUITING

    Najing, Jiangsu, 210001, China

  • National Hospital Organization Osaka Minami Medical Center

    RECRUITING

    Kawachi-Nagano, Osaka, 586-8521, Japan

  • National Taiwan University Hospital

    RECRUITING

    Taipei, 10002, Taiwan

  • NewportNativeMD, Inc.

    RECRUITING

    Newport Beach, California, 92663, United States

  • North Ingalls Building

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • North Manchester General Hospital

    RECRUITING

    Crumpsall, M8 5RB, United Kingdom

  • OK Clinical Research

    RECRUITING

    Edmond, Oklahoma, 73034, United States

  • Omnimodus Elixír Kft.

    RECRUITING

    Mosonmagyaróvár, Győr-Moson-Sopron, 9200, Hungary

  • Outpatients

    RECRUITING

    Cambridge, Cambridgeshire, cb2 0qq, United Kingdom

  • PULMAG s.c.

    RECRUITING

    Sosnowiec, Silesian Voivodeship, 41-208, Poland

  • Pinderfields General Hospital

    RECRUITING

    Wakefield, WF1 4DG, United Kingdom

  • Policlinico Universitario Monserrato

    RECRUITING

    Monserrato, Cagliari, 09042, Italy

  • Premier Research Center, LLC

    RECRUITING

    Hendersonville, Tennessee, 37075, United States

  • Ruijin Hospital Shanghai Jiaotong University School of Medicine

    NOT_YET_RECRUITING

    Shanghai, Shanghai Municipality, China

  • Rutgers, Robert Wood Johnson Medical School

    RECRUITING

    New Brunswick, New Jersey, 08901, United States

  • Samsung Medical Center

    RECRUITING

    Seoul, Seoul-teukbyeolsi [seoul], 06351, South Korea

  • Severance Hospital, Yonsei University Health System

    RECRUITING

    Seoul, Seoul-teukbyeolsi [seoul], 03722, South Korea

  • Shanghai General Hospital

    RECRUITING

    Shanghai, Shanghai Municipality, 200080, China

  • Shanghai Pulmonary Hospital

    NOT_YET_RECRUITING

    Shanghai, Shanghai Municipality, 200433, China

  • South Texas Medical Research Institute, Inc., DBA TTS Research

    RECRUITING

    Boerne, Texas, 78006, United States

  • Specjalistyczna Przychodnia Lekarska Alergo-Med Sp. z o.o

    RECRUITING

    Poznan, Greater Poland Voivodeship, 61-578, Poland

  • St. Augustine's Medical Centre 2

    NOT_YET_RECRUITING

    Durban, KwaZulu-Natal, 4001, South Africa

  • Stern Research Partners, LLC

    RECRUITING

    Huntersville, North Carolina, 28078, United States

  • Synapta Clinical Research Centre

    NOT_YET_RECRUITING

    Durban, KwaZulu-Natal, 4001, South Africa

  • Szalay János Rendelőintézet

    RECRUITING

    Hajdúnánás, Hajdú-Bihar, 4080, Hungary

  • Taichung Veterans General Hospital

    RECRUITING

    Taichung, 407, Taiwan

  • Taizhou Central Hospital

    NOT_YET_RECRUITING

    Taizhou, Zhejiang, 318000, China

  • The Affiliated Hospital of Inner Mongolia Medical University

    RECRUITING

    Hohhot, Inner Mongolia, 010050, China

  • The Affiliated Hospital of Xuzhou Medical College

    RECRUITING

    Xuzhou, Jiangsu, 221006, China

  • The Catholic Univ. of Korea Seoul St. Mary's Hospital

    RECRUITING

    Seoul, Seoul-teukbyeolsi [seoul], 06591, South Korea

  • The Catholic University of Korea, Eunpyeong St. Mary's Hospital

    RECRUITING

    Seoul, Seoul-teukbyeolsi [seoul], 03312, South Korea

  • The First Affiliated Hospital of Baotou Medical College

    NOT_YET_RECRUITING

    Baotou, Inner Mongolia, 014010, China

  • The First Affiliated Hospital of Xi'an Medical University

    RECRUITING

    Xi'an, Shaanxi, 710077, China

  • The First People's Hospital of Hangzhou

    NOT_YET_RECRUITING

    Hangzhou, Zhejiang, China

  • The Second Hospital of Jilin University

    RECRUITING

    Changchun, Jilin, 130000, China

  • The Third Affiliated Hospital of Guangzhou Medical University

    RECRUITING

    Guangzhou, Guangdong, 510150, China

  • Tokyo Medical University Hachioji Medical Center

    RECRUITING

    Hachiōji, Tokyo, 1930998, Japan

  • Toledo Institute of Clinical Research Inc.

    RECRUITING

    Toledo, Ohio, 43617, United States

  • UZ Gent

    RECRUITING

    Ghent, Oost-vlaanderen, 9000, Belgium

  • University of Kansas Medical Center

    RECRUITING

    Kansas City, Kansas, 66160, United States

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • Velocity Clinical Research, Mobile

    RECRUITING

    Mobile, Alabama, 36608, United States

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

  • West China Hospital, Sichuan University

    NOT_YET_RECRUITING

    Chengdu, Sichuan, 610041, China

  • Wythenshawe Hospital

    RECRUITING

    Manchester, Greater Manchester, M23 9LT, United Kingdom

  • Xuzhou Central Hospital

    NOT_YET_RECRUITING

    Xuzhou, Jiangsu, 221009, China

  • Yeungnam Univeristy Medical Center

    RECRUITING

    Daegu, Taegu-kwangyǒkshi, 42415, South Korea

  • Yeungnam University hospital

    RECRUITING

    Daegu, Kyǒngsangbuk-do, 42415, South Korea

  • Zhejiang Provincial People's Hospital

    RECRUITING

    Hangzhou, Zhejiang, 310014, China

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