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New knee device tracked in 757-Patient study

NCT ID NCT03034811

Disease control Sponsor: Zimmer Biomet Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 757 people who received the Persona Partial Knee system, a device used to replace only the damaged part of the knee. The goal is to see how long the implant lasts and how well patients function afterward. Participants have knee arthritis or related conditions and are at least 18 years old.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Persona Partial Knee system (a fixed-bearing partial knee replacement device)
What this could lead to
If successful, this study could confirm that the Persona Partial Knee system provides lasting pain relief and improved function for people with knee arthritis.
What could go wrong
This is an observational study of an already available device, not a test of a new cure. Results may vary by patient, and some may still need a full knee replacement later.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

757 people

The number who actually took part.

Started

Feb 2017

Expected to finish

Sep 2030

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient is at least 18 years of age * Patient qualifies for knee arthroplasty based upon physical exam and medical history, and meets the approved indications for use of the Persona Partial Knee system. * Patient has participated in a study-related Informed Consent process * Patient is willing and able to provide written Informed Consent by signing and dating the IRB/EC approved Informed Consent form * Patient is willing and able to complete scheduled study procedures and follow-up evaluations * Independent of study participation, patient is a candidate for the commercially available Persona Partial Knee, implanted in accordance with product labeling Exclusion Criteria: * Patient is currently participating in any other surgical intervention studies or pain management studies * Infection, sepsis, and osteomyelitis * Rheumatoid arthritis or other forms of inflammatory joint disease * Insufficiency of the collateral, anterior or posterior cruciate ligaments which would preclude stability of the device * Full thickness damage to the weight bearing area of the contralateral compartment * Uncooperative patient or patient with neurologic disorders who is incapable of following directions * Insufficient bone stock to provide adequate support and/or fixation to the prosthesis * Metabolic disorders which may impair bone formation * Osteomalacia * Distant foci of infections which may spread to the implant site * Rapid joint destruction, marked bone loss or bone resorption apparent on roentgenogram * Vascular insufficiency, muscular atrophy, neuromuscular disease * Incomplete or deficient soft tissue surrounding the knee * Charcot's disease * Fixed varus deformity (not passively correctable) of greater than 15 degrees * Fixed flexion deformity (not passively correctable) of greater than 15 degrees * Patient is pregnant or considered a member of a protected population (e.g., prisoner, mentally incompetent, etc.)

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Conditions

The condition(s) this trial relates to.

avascular necrosis osteoarthritis osteonecrosis tibia fracture

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Avascular necrosis Conditional revision of the articular surface Conditional tibial condyle or plateau fractures Osteoarthritis Traumatic arthritis

Contacts and locations

Locations

  • Avon Orthopaedic Centre, Southmead Hospital

    Bristol, United Kingdom

  • Cliniques Universitaires Saint-Luc

    Woluwe-Saint-Lambert, Belgium

  • Fondazione IRCCS Policlinico San Matteo

    Pavia, Italy

  • Harrogate and District NHS Foundation Trust

    Harrogate, United Kingdom

  • Henry County Orthopedics and Sports Medicine

    New Castle, Indiana, 47362, United States

  • Hessing Stiftung

    Augsburg, Germany

  • Hopital d'Yverdon les Bains

    Yverdon-les-Bains, Switzerland

  • Hospital Alcorcón

    Madrid, Spain

  • Marseille University-Hospital Centres

    Marseille, France

  • Midlands Orthopaedics & Neurosurgery

    Columbia, South Carolina, 29201, United States

  • Midwest Orthopaedics at Rush

    Chicago, Illinois, 60612, United States

  • New Mexico Orthopaedics

    Albuquerque, New Mexico, 87106, United States

  • Orthopedic Institute IRCCS

    Milan, Italy

  • Orthopädisches Spital Speising

    Vienna, Austria

  • Panorama Orthopedics & Spine Center

    Golden, Colorado, 80401, United States

  • Public Hospital of Versailles

    Versailles, France

  • Royal Derby Hospital

    Derby, United Kingdom

  • Sah Orthopaedic Associates

    Fremont, California, 94538, United States

  • Sana Kliniken Sommerfeld

    Berlin, Germany

  • Skagit Regional Clinics-Riverbend

    Mount Vernon, Washington, 98273, United States

  • Sports Medicine North

    Beverly, Massachusetts, 01960, United States

  • Troy Orthopaedic Associates

    Troy, Michigan, 48084, United States

  • Umea University Hospital

    Umeå, Sweden

  • Waldkrankenhaus Eisenberg

    Eisenberg, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.