New knee implant under study: will it ease arthritis pain?
NCT ID NCT05787821
First seen Oct 31, 2025 · Last updated Jun 23, 2026 · Updated 33 times
Summary
This study is testing the Persona knee implant in 760 people who need knee replacement due to arthritis or knee deformities. The goal is to see if the implant is safe, works well, and improves patients' pain and function. Participants will be followed for several years to track outcomes like knee scores and quality of life.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
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Denver Hip & Knee, Inc.
RECRUITINGParker, Colorado, 80138, United States
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Duke University
RECRUITINGMorrisville, North Carolina, 27560, United States
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Foundation for Orthopaedic Research & Education
RECRUITINGTampa, Florida, 33607, United States
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55902, United States
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Mississippi Sports Medicine and Orthopaedic Center
ACTIVE_NOT_RECRUITINGJackson, Mississippi, 39202, United States
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NYU
RECRUITINGNew York, New York, 11016, United States
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New Mexico Orthopaedic Associates
RECRUITINGAlbuquerque, New Mexico, 87110, United States
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Northside Hospital, Inc.
ACTIVE_NOT_RECRUITINGAtlanta, Georgia, 30342, United States
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OrthoCarolina Research Institute, Inc.
RECRUITINGCharlotte, North Carolina, 28207, United States
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St. Francis Hospital & Heart Center
RECRUITINGRoslyn, New York, 11576, United States
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Syracuse Orthopaedic Specialists
RECRUITINGDeWitt, New York, 13214, United States
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U of L Health
RECRUITINGLouisville, Kentucky, 40202, United States
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UT Health at Houston
RECRUITINGHouston, Texas, 77030, United States
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UVA Health Orthopedic Center
ACTIVE_NOT_RECRUITINGCharlottesville, Virginia, 22903, United States
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University of Michigan
ACTIVE_NOT_RECRUITINGAnn Arbor, Michigan, 48109, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Persona knee implant (a device for total knee replacement)
What this could lead to
If successful, this could confirm that the Persona knee implant is safe and effective for relieving pain and improving function in people needing knee replacement.
What could go wrong
This is an observational study, not a randomized trial, so results may not prove the implant is better than other options. Some patients may still have complications like infection or implant loosening.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.